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Milrinone

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Definition: A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.     
Pharmacological Action Cardiotonic Agents; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Vasodilator Agents 		Other names Win47203; Win 47203; Lactate, Milrinone; Win-47203; Sanofi Winthrop Brand of Milrinone Lactate; Sanofi Synthelabo Brand of Milrinone Lactate; Sanofi Synthelabo Brand of Milrinone; Sanofi Brand of Milrinone Lactate; Primacor; Milrinone Lactate; Corotrope; CorotropDrugs* : MILRINONE LACTATE IN DEXTROSE 5%; MILRINONE LACTATE; PRIMACOR; PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; MILRINONE LACTATE IN PLASTIC CONTAINER
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-ethyl-5-propionyl-1,2-dihydro-2-oxo-3-pyridine carbonitrile  0   Milrinone/*analogs & derivatives. J Pharmacol Exp Ther 1997 Nov;283(2):541-7
SF 349  0   Milrinone/*analogs & derivatives. Gen Pharmacol 1997 May;28(5):781-8
SF 348  0   Milrinone/*analogs & derivatives. Gen Pharmacol 1997 May;28(5):781-8
WIN 63291  144967-96-4 3-Pyridinecarbonitrile, 1,2-dihydro-6-methyl-2-oxo-5-(6-quinolinyl)  *Quinolines Milrinone/*analogs & derivatives. J Cardiovasc Pharmacol 1994 Sep;24(3):403-10

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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