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Digitalis Glycosides

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Definition: Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.  cardiotonics; the pharmacological principle in the plant Digitalis   
Pharmacological Action Anti-Arrhythmia Agents; Cardiotonic Agents; Enzyme Inhibitors
Examples Digitonin; Digitoxin; Digoxin; Lanatosides 		Other names Glycosides, Digitalis
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
neriumogenin-A-digitaloside  0   *Steroids Digitalis Glycosides. J Nat Prod 1999 Jul;62(7):1065-7
digitalin  752-61-4   *Digitalis Glycosides Digitalis. C R Soc Acad Sci (III) 1982;294(10):421
gitonin  39937-47-8 beta-D-Galactopyranoside, (2 alpha,3 beta,5 alpha,25R)-2-hydroxyspirostan-3-yl O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)  *Digitalis Glycosides. Brain Res Bull 1980;5(6):703
helveticosol 3',4'-dinitrate  51943-33-0 (3 beta,5 beta)-3-((2,6-dideoxy-3,4-di-O- nitro-beta-D-ribo-hexopyranosyl)oxy)-5,14,19- trihydroxycard-20(22)-enolide  *Strophanthins Cardiac Glycosides Digitalis Glycosides. Arch Int Pharmacodyn Ther 239(2):270;1979
strophanthidin digitaloside  65681-32-5 Card-20(22)-enolide, 3-((6-deoxy-3-O-methyl-D-galactosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)  Strophanthidin/*analogs & derivatives Digitalis Glycosides. Arch Pharm (Weinheim) 310(11):905;1977
3',4'-dipropionylhelveticosol  20045-25-4   *Digitalis Glycosides. Inner Med 31(13):501;1976
ASI-222  59006-00-7 (3 beta,5 beta)-3-((4-amino-4,6-dideoxy-beta-D-galactopyranosyl)oxy)-14-hydroxycard-20(22)-enolide  Digitoxigenin/*analogs & derivatives Cardiac Glycosides Digitalis Glycosides. Arch Int Pharmacodyn Ther 227:220;1977; Circ Res 43(6):847;1978; J Pharmacol Exp Ther 197(1):19;1976
Wenckebach's Dragee  78920-40-8 Strychnidin-10-one, mononitrate, mixt. with Digitalis glycosides and (8alpha,9R)-6'-methoxycinchonan-9-ol sulfate (2:1) (salt)  *Digitalis Glycosides *Quinine *Strychnine Drug Combinations. Sud Med Ekspert 16(2):40;1973
tridigal  0   *Digitalis Glycosides. Vutr Boles 13(3):63-70;1974
helveticoside  630-64-8 3-beta-5,14-trihydroxy-19-oxo-5-beta-card-20(22)- enolid-3-digitoxoside /OD/ K-Strophanthidin-3- digitoxoside /OD/ erysimin  *Digitalis Glycosides *Strophanthins. Farm Zh 31(5):47;1976; Farm Zh 6:52;1978
actodigin  36983-69-4   *Cardenolides Digitalis Glycosides. Ann NY Acad Sci 242(0):675;1974; Arch Int Pharmacodyn Ther 228:92;1977; Clin Pharmacol Ther 22(3):274;1977; Eur J Pharmacol 19:291;1972; Eur J Pharmacol 32:1;1975; Eur J Pharmacol 33:223;1975; J Pharmacol Exp Ther 188(1):189;1974; Naunyn Schmiedebergs Arch Pharmacol 1979;308(2):81; Naunyn-Schmiedebergs Arch Pharmacol 297:91;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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