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Benzothiadiazines

More information in Books or onNLM PubMed
Definition: Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.     
Examples Bendroflumethiazide; Chlorothiazide; Cyclopenthiazide; Diazoxide; Hydroflumethiazide; Methyclothiazide; Polythiazide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem. 2011 Dec 22;54(24):8353-61.
N-(1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-7-ethyl-1-methyl-3,4-dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9-carboxamide 2,2-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem. 2008 Jun 12;51(11):3313-7.
7-chloro-3-(3-pentylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. Drug Metab Dispos 2010 Feb;38(2):232-40
7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 2010 Feb 25;53(4):1700-11
6-chloro-3-cyclobutylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 2010 Jan 14;53(1):147-54
8-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 2010 Jan 14;53(1):147-54
2,3,3a,4-tetrahydro-1H-pyrrolo(2,1-c)(1,2,4) benzothiadiazine 5,5-dioxide  0   *Benzothiadiazines *Oxides. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):192-9
4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 2007 Jun 28;50(13):3153-7
A 837093  0   *Benzothiadiazines *Cyclic S-Oxides. Antimicrob Agents Chemother 2007 Dec;51(12):4290-6
1,3,2,4-benzodithiadiazine  0   *Benzothiadiazines. J Phys Chem A Dyn Kinet Environ Chem Spectrosc Struct Theory 2007 Feb 8;111(5):817-24
flumethiazide  0 10,10-dioxo-4-(trifluoromethyl)-10-lamda6-thia-7,9-diazabicyclo(4.4.0)deca-2,4,8,11-tetraene-3-sulfonamide  *Benzothiadiazines Diuretics.
6-chloro-7-fluoro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 2005 Jul 28;48(15):4990-5000
BPDZ 154  0   *Benzothiadiazines *Cyclic S-Oxides. J Clin Endocrinol Metab 2002 Nov;87(11):4860-8
3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide  0   *Benzothiadiazines. Chirality 2001 Feb;13(2):94-101
S18986-1  0   *Benzothiadiazines. Eur J Pharmacol 2000 Aug 4;401(2):145-53
1-((4-chlorophenyl)methyl)-3-benzyl-2,1,3-benzothiadiazin-4-one 2,2-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 2000 Aug 24;43(17):3267-73
1-benzyl-3-(benzyloxymethyl)-2,1,3-benzothiadiazin-4-one 2,2-dioxide  0   *Benzothiadiazines *Cyclic S-Oxides. J Med Chem 1999 Apr 8;42(7):1145-50
RPR 104632  154106-92-0   *Benzothiadiazines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. Eur J Pharmacol 1996 Apr 11;300(3):237-46
IDRA 21  22503-72-6   *Benzothiadiazines. J Pharmacology Exp Ther 1995 Jan;272(1):300-9
4-(6,7-dichloro-4H-1,2,4-benzothiadiazine-3-yl)-2,6-bis(1,1-dimethylethyl)phenol-S,S-dioxide  150457-40-2   *Benzothiadiazines *Phenols. Pharmacol Res 1993 May-Jun;27(4):349-58
4-(4H-1,2,4-benzothiadiazine-3-yl)-2,6-bis(dimethylethyl)phenol-S,S-dioxide  150457-39-9   *Benzothiadiazines *Phenols. Pharmacol Res 1993 May-Jun;27(4):349-58
Goe 4962  103541-73-7   *Benzothiadiazines. J Pharm Pharmacol 1987;39(5):407
QM 7184  76865-42-4 1H-6-Thia-13a-azabenzo(f)naphth(1,2,3-cd)azulene, 2,3,4,4a,7,8,12b,13-octahydro-, trans-(+-)  *Cycloheptanes Benzothiadiazines Thiophenes. Arzneimittelforsch 1983;33(10):1417
tensigradyl  64238-91-1 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(1-phenylethyl)-, 1,1-dioxide, mixt. with ((2,3-dihydro-1,4-benzodioxin-6-yl)methyl)guanidine sulfate (2:1)  *Benzothiadiazines *Guanidines Drug Combinations. G Clin Med 1982;63(4):270
cyclothiazide, triamterene drug combination  0   *Benzothiadiazines *Triamterene Drug Combinations. Therapie 1982;37(2):220
6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide  80938-51-8 2H-1,2,4-Benzothiadiazine-6-methanamine, 3-methyl-, 1,1-dioxide, monohydrochloride  *Benzothiadiazines. J Pharmacol Exp Ther 1981;219(3):604
bemetizide, bupranolol, triamterene drug combination  0   *Benzothiadiazines *Bupranolol *Triamterene Drug Combinations. MMW 1980;122(7):247
2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid  57864-78-5   *Benzothiadiazines. Farm Zh (5):42;1978
hypertane  63764-56-7 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(1-phenylethyl)-, 1,1-dioxide, mixt. with 6-phenyl-2,4,7-pteridinetriamine  *Benzothiadiazines *Triamterene Drug Combinations. Verh Deutsh Ges Inn Med 83:1722;1977
pipazethate  2167-85-3   *Benzothiadiazines.
Pharma Action Antitussive Agents 		Clin Toxicol 11(4):455;1977
DU 717  59943-31-6 7-chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine-1,1-dioxide  *Benzothiadiazines. Experientia 33(1):55;1977; J Chromatogr 160(1):181;1978; J Chromatogr 1979;169:439
bemetizide, triamterene drug combination  0   *Benzothiadiazines *Hesperidin *Thiamine *Triamterene Drug Combinations. Fortschr Med 92(28):1132;1974; Med Welt 26(37):1679;1975; Med Welt 29(24):1016;1978; Med Welt 29(4):150;1978
dehydrosanol  1824-52-8 6-chlor-3,4-dihydro-3-(alpha-methylbenzyl)-7-sulfamoyl-2H-1,2,4-benzothiadiazine-1,1-dioxide  *Benzothiadiazines. Arzneim Forsch (Drug Res) 27(3):559;1977; Arzneim Forsch (Drug Res) 27(9):1026;1977; Fortschr Med 92(28):1132;1974; J Chromatogr 146(1):152;1978; Med Welt 26(21):1043;1975; Med Welt 29(49):1936;1978; Verh Dtsch Ger Inn Med 83:1722;1977
penfluzide  1766-91-2   *Benzothiadiazines. Folia Pharmacol Jpn 69(5):749;1973
mebutizide  3568-00-1 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(1,2-dimethylbutyl)-3,4-dihydro-, 1,1-dioxide  *Benzothiadiazines.
2H-1,2,4-benzothiadiazine-1,1-dioxide  359-85-3   *Benzothiadiazines. Il Farmaco 29(12):910;1974
althiazide  5588-16-9 6-chloro-3,4-dihydro-3-((2-propenylthio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide  *Benzothiadiazines Juvenile Hormones. Med Parazitol (Mosk) 1980;49(1):55
cyclothiazide  2259-96-3 6-chloro-3,4-dihydro-3-(norbornen-2-yl)-2H-1,2,4- benzothiadiazine-7-sulfonamide 1,1-dioxide  *Benzothiadiazines Receptors, AMPA.
Pharma Action Antihypertensive Agents ; Diuretics 		Eur J Clin Pharmacol 12:161;1977; J Assoc Off Anal Chem 59(1):90;1976; Munch Med Wochenschr 119(34):1085;1977ANHYDRON; FLUIDIL
benzothiazide  91-33-8 3-((benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide  *Benzothiadiazines. Cur Ther Res 20(3):259;1976; J Assoc Phys India 25:31;1977FOVANE; EXNA; URESE; BENZTHIAZIDE; AQUATAG
FH 109 C  0   *Benzothiadiazines *Canrenoate Potassium Reserpine/*analogs & derivatives.
bentazone  25057-89-0 3-isopropyl-4H-2,1,3-benzothiadiazin-4-one 2,2-dioxide  *Benzothiadiazines.
Pharma Action Herbicides 		Agr. Food Chem 23(3):410;1975; Xenobiotica 2(3):269;1972
folescutol, meprobamate, paraflutizide, rescinnamine drug combination  0   *Benzothiadiazines *Meprobamate *Morpholines Drug Combinations.
paraflutizide  1580-83-2 6-chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide, 1,1-dioxide  *Benzothiadiazines.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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