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Aldehyde Reductase
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Definition
: An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.
Other names
Aldose Reductase; Reductase, Xylose; Reductase, Erythrose; Reductase, Aldose; Reductase, Aldehyde; Reductase Ib, Aldose; Reductase Ia, Aldose; Xylose Reductase; Erythrose Reductase; Aldose Reductase Ib; Aldose Reductase Ia
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(3beta-
hydroxyurs-
12-
en-
28-
oyl)-
4-
aminobutyric acid
0
*Triterpenes
Aldehyde Reductase/antagonists & inhibitors.
Bioorg Khim. 2011 Sep-Oct;37(5):637-44
glucodistylin
0
*Glycosides
*Flavonols
Aldehyde Reductase/antagonists & inhibitors.
Arch Pharm Res. 2011 Feb;34(2):181-9
IDD 393
0
*Benzene Derivatives
Aldehyde Reductase/antagonists & inhibitors.
Biochim Biophys Acta. 2011 Sep;1810(9):879-87
Akr1b7 protein, rat
EC 1.1.1.-
*Aldehyde Reductase.
Biol Pharm Bull. 2010;33(11):1886-90
ganoderic acid C2
0
*Triterpenes
Aldehyde Reductase/antagonists & inhibitors.
Planta Med. 2010 Oct;76(15):1691-3
semilicoisoflavone B
0
*Flavonoids
Aldehyde Reductase/antagonists & inhibitors.
Biol Pharm Bull 2010;33(5):917-21
2-
(3,4-
dihydroxyphenyl)-
6-
hydroxypyrido(1,2-
a)pyrimidin-
4-
one
0
*Pyridines
*Pyrimidinones
Aldehyde Reductase/antagonists & inhibitors.
J Pharm Pharmacol 2010 Jan;62(1):107-13
Akr1b10 protein, rat
EC 1.1.1.-
*Aldehyde Reductase.
Arch Biochem Biophys. 2010 Nov 15;503(2); 230-7
(6-
methyl-
3-
(4,5,7-
trifluorobenzothiazol-
2-
ylmethyl)pyrrolo(2,3-
b)pyridin-
1-
yl)acetic acid
0
*Benzothiazoles
Aldehyde Reductase/antagonists & inhibitors.
Bioorg Med Chem Lett 2009 Apr 1;19(7):2006-8
N2-
(2-
methylaminobenzoyl)tetrahydro-
1H-
pyrido(3,4-
b)indol-
1-
one
0
*Carbolines
Aldehyde Reductase/antagonists & inhibitors.
Yakugaku Zasshi 1967 May;87(5):608-10
Akr1b8 protein, rat
EC 1.1.1.-
*Aldehyde Reductase.
Chem Biol Interact 2009 Mar 16;178(1-3):151-7
2-
(3-
(4-
methoxyphenyl)-
1,2,4-
oxadiazol-
5-
yl)acetic acid
0
*Acetic Acids
*Oxadiazoles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2008 Jun 12;51(11):3182-93
YqhD protein, E coli
EC 1.1.1.21
*Aldehyde Reductase
*Escherichia coli Proteins.
J Biol Chem 2008 Mar 21;283(12):7346-53
(2-
benzyl-
2,3,4,5-
tetrahydro-
1H-
pyrido(4,3-
b)indole-
8-
yl)-
acetic acid
0
*Acetic Acids
*Indoles
Aldehyde Reductase/antagonists & inhibitors.
Gen Physiol Biophys. 2006 Dec;25(4):415-25
furfural reductase, E coli
EC 1.1.1.21
*Aldehyde Reductase.
J Biotechnol 2006 Jan 24;121(2):154-64
aldehyde reductase AKR1A4, mouse
EC 1.1.1.21
*Aldehyde Reductase.
Toxicol Appl Pharmacol 2006 Jan 1;210(1-2):163-70
lidorestat
0
*Indoleacetic Acids
*Thiazoles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2005 May 5;48(9):3141-52
Idd 594
0
*Acetates
*Thioamides
Aldehyde Reductase/antagonists & inhibitors.
Proteins 2004 Jun 1;55(4):792-804
(3-
benzoylpyrrol-
1-
yl)acetic acid
0
*Acetic Acids
*Pyrroles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2004 May 6;47(10):2706-9
(1-
(3,5-
difluoro-
4-
hydroxyphenyl)-
1H-
pyrrol-
3-
yl)phenylmethanone
0
*Phenols
*Pyrroles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2004 May 6;47(10):2706-9
AKR1B1 protein, human
EC 1.1.1.21
*Aldehyde Reductase.
4-
oxo-
4-
(4-
hydroxyindole)butanoic acid
0
*Butyric Acids
*Indoles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2003 Dec 18;46(26):5619-27
6-
(5-
chloro-
3-
methylbenzofuran-
2-
sulfonyl)-
2H-
pyridazin-
3-
one
0
*Pyridazines
*Sulfones
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2003 Jun 5;46(12):2283-6
asperaldin
0
*Naphthoquinones
Aldehyde Reductase/antagonists & inhibitors.
J Antibiot (Tokyo) 2003 Feb;56(2):173-6
cyano(5-
fluoro-
1-
(4-
methylbenzyl)-
2-
oxo-
2,3-
dihydroindol-
3-
yl)acetic acid
0
*Indoles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2003 Apr 10;46(8):1419-28
minalrestat
129688-50-2
*Imides
*Quinolones
Aldehyde Reductase/antagonists & inhibitors.
J Pharmacol Exp Ther 2003 Mar;304(3):1236-42
(2,4-
bis(4-
methoxybenzoyl)pyrrol-
1-
yl)acetic acid
0
*Acetic Acids
*Pyrroles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2003 Jan 30;46(3):417-26
renal-
specific oxidoreductase, mouse
EC 1.1.1.21
*Aldehyde Reductase.
Proc Natl Acad Sci U S A 2000 Aug 29;97(18):9896-901
YUA001
0
Tyramine/*analogs & derivatives
Aldehyde Reductase.
J Antibiot (Tokyo) 2001 Oct;54(10):827-30
(10-
benzyl-
(1,2,4)triazino(4,3-
a)benzimidazol-
3,4(10H)-
dion-
2-
yl)acetic acid
0
*Benzimidazoles
*Triazines
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2001 Dec 6;44(25):4359-69
AKR7A1
EC 1.1.1.-
*Aldehyde Reductase.
Biochem Pharmacol 2001 Dec 1;62(11):1511-9
1H,7H-
5a,6,8,9-
tetrahydro-
1-
oxopyrano(4,3-
b)(1)benzopyran-
3-
acetic acid
0
*Acetic Acids
*Benzopyrans
Aldehyde Reductase/antagonists & inhibitors.
Mol Vis 2001 Jul 18;7:164-71
succinic acid benzyl ester 3-
carboxymethyl-
1-
(4-
chlorobenzoyl)-
2-
methylindol-
5-
yl ester
0
*Indoles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 2001 May 24;44(11):1718-28
androgen-
inducible aldehyde reductase
EC 1.2.1.-
*Aldehyde Reductase.
Endocrinology 2000 Sep;141(9):3194-9
IDD384
0
*Sulfones
Aldehyde Reductase/antagonists & inhibitors.
Acta Crystallogr D Biol Crystallogr 2000 May;56 ( Pt 5):536-40
kotalagenin 16-
acetate
0
*Triterpenes
Aldehyde Reductase/antagonists & inhibitors
Glucosidases/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1999 Dec;47(12):1725-9
AKR1B10 protein, human
EC 1.1.1.-
*Aldehyde Reductase.
Adv Exp Med Biol 1999;463:427-34; J Biol Chem 1998 May 8;273(19):11429-35
kikkanol C
0
*Sesquiterpenes
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1999 Mar;47(3):340-5
kikkanol B
0
*Sesquiterpenes
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1999 Mar;47(3):340-5
kikkanol A
0
*Sesquiterpenes
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1999 Mar;47(3):340-5
3-
methyl-
4-
(4-
chlorophenyl)isoxazolo(3,4-
d)pyridazin-
7(6H)-
one acetic acid
0
*Isoxazoles
*Pyridazines
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 1999 Jun 3;42(11):1894-900
spirofluorene-
9,5'-
imidazolidine-
2',4'-
dione
0
*Spiro Compounds
*Imidazolidines
Aldehyde Reductase/antagonists & inhibitors.
Bioorg Med Chem 1998 Oct;6(10):1811-9
SX 3030
0
*Pyrazines
*Spiro Compounds
Aldehyde Reductase/antagonists & inhibitors
Stereoisomerism.
J Med Chem 1998 Oct 8;41(21):4118-29
salvianolic acid K
0
*Cinnamates
*Phenylpropionates
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull 1998 Mar;46(3):500-4
lithospermic acid B
121521-90-2
*Benzofurans
*Depsides
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull 1998 Mar;46(3):500-4
salviaflaside
178895-25-5
*Glucosides
*Phenylpropionates
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull 1998 Mar;46(3):500-4
danshenol B
0
*Diterpenes
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1997 Aug;45(8):1306-11
danshenol A
0
*Diterpenes
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1997 Aug;45(8):1306-11
GP 1447
0
*Phenylacetates
*Thiazoles
Aldehyde Reductase/antagonists & inhibitors.
Jpn J Pharmacol 1997 Feb;73(2):133-44
3-
((5-
chlorobenzothiazol-
2-
yl)methyl)-
1,2,3,4-
tetrahydro-
2,4-
dioxopyrimidine-
1-
acetic acid
0
*Pyrimidinones
*Thiazoles
Aldehyde Reductase/antagonists & inhibitors.
J Med Chem 1997 Feb 28;40(5):684-94
ONO 3
0
*Acetic Acids
*Thiazoles
Aldehyde Reductase/antagonists & inhibitors.
Eur J Biochem 1997 Jan 15;243(1-2):274-82
ONO 1
0
*Furans
*Thiazoles
Aldehyde Reductase/antagonists & inhibitors.
Eur J Biochem 1997 Jan 15;243(1-2):274-82
ICI 222155
132414-04-1
*Nitroparaffins
*Sulfones
Aldehyde Reductase/antagonists & inhibitors.
Eur J Pharmacol 1995 Oct 16;285(2):189-97
35-
kDa hypertonic stress protein, human
0
*Heat-Shock Proteins
Aldehyde Reductase.
Cell Biochem Funct 1995 Mar;13(1):1-8
WAY 121-
509
0
Aldehyde Reductase/*antagonists & inhibitors.
Diabetes Res Clin Pract 1994 Sep;25(2):117-29
matteuorienate B
161161-69-9 Pentanedioic acid, 3-
hydroxy-
3-
methyl-
, 6'-
ester with 7-
(beta-
D-
glucopyranosyloxy)-
2,3-
dihydro-
5-
hydroxy-
6,8-
dimethyl-
2-
phenyl-
4H-
1-
benzopyran-
4-
one
*Flavonoids
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1994 Aug;42(8):1712-4
matteuorienate A
161161-68-8 Pentanedioic acid, 3-
hydroxy-
3-
methyl-
, 6'-
ester with 7-
(beta-
D-
glucopyranosyloxy)-
2,3-
dihydro-
5-
hydroxy-
2-
(4-
methoxyphenyl)-
6,8-
dimethyl-
4H-
1-
benzopyran-
4-
one
*Flavonoids
Aldehyde Reductase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 1994 Aug;42(8):1712-4
ZENECA ZD 5522
0
*Acetanilides
*Sulfones
Aldehyde Reductase/antagonists & inhibitors.
Diabetologia 1994 Jul;37(7):651-63
SPR 210
143162-65-6
*Thiazines
*Benzothiazoles
Aldehyde Reductase/antagonists & inhibitors.
Jpn J Pharmacol 1994 Feb;64(2):115-24
aflatoxin B1 aldehyde reductase
EC 1.1.1.-
*Aldehyde Reductase.
Cancer Res 1993 Sep 1;53(17):3887-94
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