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| An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.
|
Pharmacological Action Immunosuppressive Agents; Cardiovascular Agents; Antineoplastic Agents; Chelating Agents | Other names Dexrazoxane; ICRF187; NSC129943; NSC 129943; ICRF159; ICRF 187; ICRF 186; ICRF 159; ADR529; ICRF186; ADR 529; Zinecard; Razoxin; Razoxane, (S)-Isomer; Razoxane, (R)-Isomer; Razoxane Mesylate, (R)-Isomer; NSC-169780; NSC-129943; ICRF-187; ICRF-186Drugs* :
DEXRAZOXANE;
ZINECARD
| |
| Substance | CAS Registry & name | Categories | Source | Drugs*
|
| bimolane
| 74550-97-3
|
Razoxane/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Radiation-Sensitizing Agents
|
Yao Hsueh Hsueh Pao 1980;15(10):577
|
1,2-bis(3,5-dioxopiperazin-1-yl)ethane
| 1506-47-4
|
Razoxane/*analogs & derivatives.
|
J Nat Cancer Inst 48(5):1347;1972
|
| probimane
| 108093-90-9
|
Razoxane/*analogs & derivatives.
|
Chung Kuo Yao Li Hsueh Pao 1987;8(4):369
|
| ICRF 192
| 58893-33-7
|
Razoxane/*analogs & derivatives.
|
Agents Actions 1982;12(4):536
|
4,4'-(1,2-cyclopropanediyl)bis(2,6-piperazinedione)
| 66054-21-5
|
Razoxane/*analogs & derivatives.
|
Br J Cancer 1981;44(4):578
|
| FMI protocol
| 0
|
*Antineoplastic Combined Chemotherapy Protocols Fluorouracil Razoxane Semustine.
|
Am J Clin Oncol 1987;10(4):320
|
| ADR 559
| 0
|
Razoxane/*analogs & derivatives.
|
Cancer Chemother Pharmacol 1997;40(5):400-8
|
| ICRF 239
| 96886-77-0
|
Razoxane/*analogs & derivatives.
|
Cancer Chemother Pharmacol 1997;40(5):400-8
|
N-(2-amino-2-oxoethyl)-N-(2-(3,5-dioxo-1-piperazinyl)-1-methylethyl)glycine
| 0
|
Glycine/*analogs & derivatives Razoxane/*analogs & derivatives.
|
Drug Metab Dispos 2005 Sep;33(9):1367-72
|
N-(2-amino-2-oxoethyl)-N-(2-(3,5-dioxo-1-piperazinyl)propyl)glycine
| 0
|
Glycine/*analogs & derivatives Razoxane/*analogs & derivatives.
|
Drug Metab Dispos 2005 Sep;33(9):1367-72
|
1,1'-(1,2-cyclopropanediyl)bis(2,6-piperazinedione)
| 62490-99-7
|
Razoxane/*analogs & derivatives.
|
J Med Chem 20(5):630;1977
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