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Razoxane
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Definition
: An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.
Pharmacological Action
Antineoplastic Agents
;
Cardiovascular Agents
;
Chelating Agents
Other names
Dexrazoxane; NSC129943; NSC 129943; ICRF187; ICRF186; ICRF159; ICRF 187; ICRF 186; ICRF 159; ADR529; ADR 529; Zinecard; Razoxin; Razoxane, (S)-
Isomer; Razoxane, (R)-
Isomer; Razoxane Mesylate, (R)-
Isomer; NSC-
169780; NSC-
129943; ICRF-
187; ICRF-
186
Drugs
*
:
TOTECT
;
ZINECARD
;
DEXRAZOXANE HYDROCHLORIDE
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(2-
amino-
2-
oxoethyl)-
N-
(2-
(3,5-
dioxo-
1-
piperazinyl)propyl)glycine
0
Glycine/*analogs & derivatives
Razoxane/*analogs & derivatives.
Drug Metab Dispos 2005 Sep;33(9):1367-72
N-
(2-
amino-
2-
oxoethyl)-
N-
(2-
(3,5-
dioxo-
1-
piperazinyl)-
1-
methylethyl)glycine
0
Glycine/*analogs & derivatives
Razoxane/*analogs & derivatives.
Drug Metab Dispos 2005 Sep;33(9):1367-72
ICRF 239
96886-77-0
Razoxane/*analogs & derivatives.
Cancer Chemother Pharmacol 1997;40(5):400-8
ADR 559
0
Razoxane/*analogs & derivatives.
Cancer Chemother Pharmacol 1997;40(5):400-8
probimane
108093-90-9
Razoxane/*analogs & derivatives.
Chung Kuo Yao Li Hsueh Pao 1987;8(4):369
FMI protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Fluorouracil
Razoxane
Semustine.
Am J Clin Oncol 1987;10(4):320
ICRF 192
58893-33-7
Razoxane/*analogs & derivatives.
Agents Actions 1982;12(4):536
4,4'-
(1,2-
cyclopropanediyl)bis(2,6-
piperazinedione)
66054-21-5
Razoxane/*analogs & derivatives.
Br J Cancer 1981;44(4):578
bimolane
74550-97-3
Razoxane/*analogs & derivatives.
Pharma Action
Antineoplastic Agents
;
Radiation-Sensitizing Agents
Yao Hsueh Hsueh Pao 1980;15(10):577
1,1'-
(1,2-
cyclopropanediyl)bis(2,6-
piperazinedione)
62490-99-7
Razoxane/*analogs & derivatives.
J Med Chem 20(5):630;1977
1,2-
bis(3,5-
dioxopiperazin-
1-
yl)ethane
1506-47-4
Razoxane/*analogs & derivatives.
J Nat Cancer Inst 48(5):1347;1972