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Razoxane

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Definition: An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.     
Pharmacological Action Antineoplastic Agents; Cardiovascular Agents; Chelating Agents 		Other names Dexrazoxane; NSC129943; NSC 129943; ICRF187; ICRF186; ICRF159; ICRF 187; ICRF 186; ICRF 159; ADR529; ADR 529; Zinecard; Razoxin; Razoxane, (S)-Isomer; Razoxane, (R)-Isomer; Razoxane Mesylate, (R)-Isomer; NSC-169780; NSC-129943; ICRF-187; ICRF-186Drugs* : TOTECT; ZINECARD; DEXRAZOXANE HYDROCHLORIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2-amino-2-oxoethyl)-N-(2-(3,5-dioxo-1-piperazinyl)propyl)glycine  0   Glycine/*analogs & derivatives Razoxane/*analogs & derivatives. Drug Metab Dispos 2005 Sep;33(9):1367-72
N-(2-amino-2-oxoethyl)-N-(2-(3,5-dioxo-1-piperazinyl)-1-methylethyl)glycine  0   Glycine/*analogs & derivatives Razoxane/*analogs & derivatives. Drug Metab Dispos 2005 Sep;33(9):1367-72
ICRF 239  96886-77-0   Razoxane/*analogs & derivatives. Cancer Chemother Pharmacol 1997;40(5):400-8
ADR 559  0   Razoxane/*analogs & derivatives. Cancer Chemother Pharmacol 1997;40(5):400-8
probimane  108093-90-9   Razoxane/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1987;8(4):369
FMI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Razoxane Semustine. Am J Clin Oncol 1987;10(4):320
ICRF 192  58893-33-7   Razoxane/*analogs & derivatives. Agents Actions 1982;12(4):536
4,4'-(1,2-cyclopropanediyl)bis(2,6-piperazinedione)  66054-21-5   Razoxane/*analogs & derivatives. Br J Cancer 1981;44(4):578
bimolane  74550-97-3   Razoxane/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Radiation-Sensitizing Agents 		Yao Hsueh Hsueh Pao 1980;15(10):577
1,1'-(1,2-cyclopropanediyl)bis(2,6-piperazinedione)  62490-99-7   Razoxane/*analogs & derivatives. J Med Chem 20(5):630;1977
1,2-bis(3,5-dioxopiperazin-1-yl)ethane  1506-47-4   Razoxane/*analogs & derivatives. J Nat Cancer Inst 48(5):1347;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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