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Siderophores

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Definition: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)      Other names Siderochromes
Substances having this pharmacologic action: mycobactins; pyochelin; aerobactin; pseudobactin; siderophore receptors; vibriobactin; pyoverdin; Enterobactin; Deferoxamine; yersiniabactin; FpvA protein, Pseudomonas aeruginosa; anguibactin; desferrithiocin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
trivanchrobactin  0   *Peptides Siderophores. J Nat Prod. 2010 Jun 25;73(6):1038-43
vanchrobactin  0   *Peptides Siderophores. Org Biomol Chem 2008 Apr 7;6(7):1278-87
ceuE protein, Campylobacter coli  0   *Bacterial Proteins *Carrier Proteins Campylobacter coli Siderophores.
pseudoalterobactin B  0   *Biological Factors Siderophores. J Antibiot (Tokyo) 2003 Oct;56(10);871-5
pseudoalterobactin A  0   *Biological Factors Siderophores. J Antibiot (Tokyo) 2003 Oct;56(10);871-5
asterobactin  0   *Biological Factors Siderophores. J Antibiot (Tokyo) 2002 Jun;55(6):593-7
petrobactin  0   *Benzamides Siderophores. J Am Chem Soc 2002 Jan 23;124(3):378-9
pyridinochelin  0   *Catechols Siderophores. Z Naturforsch [C] 2001 Jul-Aug;56(7-8):540-6
ceuE protein, Campylobacter jejuni  0   *Bacterial Proteins *Carrier Proteins Campylobacter jejuni Siderophores. Diag Microbiol Infect Dis 2001 May-Jun;40(1-2):11-9
pseudomonine  0   *Benzamides Siderophores. J Bacteriol 2001 Mar;183(6):1909-20
anachelin  0   *Quinolinium Compounds Siderophores. Z Naturforsch (C) 2000 Sep-Oct;55(9-10):681-7
coelichelin  0   *Oligopeptides Siderophores Peptide Biosynthesis, Nucleic Acid-Independent. FEMS Microbiol Lett 2000 Jun 15;187(2):111-4
coprogen B  0   *Hydroxamic Acids Siderophores. Infect Immun 2000 Apr;68(4):2338-43
quinolobactin  0   *Quinolines Siderophores. Appl Environ Microbiol 2000 Feb;66(2):487-92
rpoI protein, Rhizobium leguminosarum  0   *Bacterial Proteins *Sigma Factor Rhizobium leguminosarum Siderophores. Mol Plant Microbe Interact 1999 Nov;12(11):994-9
FR 160  0   Spermidine/*analogs & derivatives Siderophores. Antimicrob Agents Chemother 1997 Aug;41(8):1837-9
6-alanineferrirubin  0   *Ferric Compounds *Peptides, Cyclic Siderophores. Acta Crystallogr C 1997 Jun 15;53( Pt 6):716-8
isopyoverdin  0   *Oligopeptides Pigments, Biological Siderophores. Z Naturforsch (C) 1995 Sep-Oct;50(9-10):622-9
acinetobactin  160472-93-5 4-Oxazolecarboxamide, 2-(2,3-dihydroxyphenyl)-4,5-dihydro-N-hydroxy-N-02-(1H-imidazol-4-yl)ethyl)-5-methyl-, cis-(-)  *Imidazoles *Oxazoles Acinetobacter Siderophores. Arch Microbiol 1994;162(4):249-54
vibrioferrin  157568-17-7 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, 1-02-002-(2-carboxy-2-hydroxy-5-oxo-1-pyrrolidinyl)-1-oxopropyl)amino)ethyl) ester  *Citrates *Pyrrolidinones Siderophores. J Biochem (Tokyo) 1994 May;115(5):868-74
rhizoferrin  138846-62-5 Butanedioic acid, 2,2'-(1,4-butanediylbis(imino(2-oxo-2,1-ethanediyl)))bis(2-hydroxy)  *Ferric Compounds Siderophores. Biochem Pharmacol 1994 May 18;47(10):1843-50
acinetoferrin  0   *Citrates *Hydroxamic Acids Siderophores. Biometals 1994 Apr;7(2):170-6
vulnibactin  156368-88-6 4-Oxazolecarboxamide, N-(3-(((4,5-dihydro-2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl)carbonyl)amino)propyl)-N-(3-((2,3-dihydroxybenzoyl)amino)propyl)-4,5-dihydro-2-(2-hydroxyphenyl)-5-methyl-, (4S-(4alpha(4R*,5S*),5beta))  *Amides *Oxazoles Siderophores. Biometals 1994 Apr;7(2):109-16
pyoverdin GM-II  0   *Oligopeptides Pigments, Biological Siderophores. Biochemistry 1994 Mar 15;33(10):2843-51
alterobactin B  153888-53-0   *Oligopeptides Siderophores. Nature 1993 Dec 2;366(6454):455-8
alterobactin A  153888-52-9   *Peptides, Cyclic Siderophores. Nature 1993 Dec 2;366(6454):455-8
urbs1 protein, Ustilago maydis  0   *Fungal Proteins *Transcription Factors Ustilago Siderophores. Mol Cell Biol 1993 Nov;13(11):7091-7100
staphyloferrin B  127689-48-9 Staphyloferrin B  *Citrates Staphylococcus Siderophores. Biometals 1993 Autumn;6(3):185-92
N(1),N(7)-bis(2,3-dihydroxybenzoyl)norspermidine  88381-35-5   *Catechols Spermidine/*analogs & derivatives Siderophores. J Biochem (Tokyo) 1993 May;113(5):538-44
fluvibactin  103185-30-4 4-Oxazolecarboxamide, N,N-bis(3-((2,3-dihydroxybenzoyl)amino)propyl)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-5-methyl-, (4S-trans)  *Catechols Spermidine/*analogs & derivatives Siderophores. J Biochem (Tokyo) 1993 May;113(5):538-44
JAM 2-263  134782-23-3   *Catechols *Lactams Siderophores. Antimicrob Agents Chemother 1992 Oct;36(10):2166-75
nannochelin C  133705-26-7 L-Lysine, N2,N2'-(3-carboxy-3-hydroxy-1,5-dioxo-1,5-pentanediyl)bis(N6-hydroxy-N6-(1-oxo-3-phenyl-2-propenyl)  *Citrates *Hydroxamic Acids Siderophores. J Antibiot (Tokyo) 1992 Feb;45(2):147-50
nannochelin B  133705-27-8 L-Lysine, N2-(3-carboxy-5-((1-carboxy-5-(hydroxy(1-oxo-3-phenyl-2-propenyl)amino)pentyl)amino)-3-hydroxy-1,5-dioxopentyl)-N6-hydroxy-N6-(1-oxo-3-phenyl-2-propenyl)-, 1-methyl ester  *Citrates *Hydroxamic Acids Siderophores. J Antibiot (Tokyo) 1992 Feb;45(2):147-50
nannochelin A  133705-25-6 L-Lysine, N2,N2'-(3-carboxy-3-hydroxy-1,5-dioxo-1,5-pentanediyl)bis(N6-hydroxy-N6-(1-oxo-3-phenyl-2-propenyl)-, 1,1'-dimethyl ester  *Citrates *Hydroxamic Acids Siderophores. J Antibiot (Tokyo) 1992 Feb;45(2):147-50
azurechelin  0   *Salicylic Acids Siderophores. J Gen Microbiol. 1993 Sep;139 ( Pt 9):1995-2001; J Med Microbiol 1992 Mar;36(3):184-9
7-((N(5)acetyl-N(5)-hydroxyornithyl-N(5)acetyl-N(5)hydroxyornithyl-N(5)-acetyl-N(5)-hydroxyornithyl-4-hydroxyphenylglycyl)amino)-3-chloro-1-carba-3-cephem-4-carboxylic acid  124620-50-4   *Lactams Siderophores. J Med Chem 1991;34(3):968
7-((N(5)-acetyl-N(5)-hydroxyornithyl-N(5)-acetyl-N(5)-hydroxyornithyl-N(5)-acetyl-N(5)-hydroxyornithyl-phenylglycyl)amino)-1-carba-3-chloro-3-cephem-4-carboxylic acid  124650-78-8   *Lactams Siderophores. J Med Chem 1991;34(3):968
hydroxyneocoprogen I  135500-10-6   *Hydroxamic Acids Siderophores. Biol Met 1990;2(1):11
hydroxyisoneocoprogen I  135500-11-7   *Hydroxamic Acids Siderophores. Biol Met 1990;2(1):11
hydroxycoprogen  135467-86-6   *Hydroxamic Acids Siderophores. Biol Met 1990;2(1):11
pseudobactin 589 A  0   *Peptides, Cyclic Siderophores. Biochemistry 1990;29(31):7348
N(alpha)-dimethylisoneocoprogen I  117852-96-7   *Hydroxamic Acids Siderophores. Biol Met 1988;1(1):4
N(alpha)-dimethylneocoprogen  117852-95-6   *Hydroxamic Acids Siderophores. Biol Met 1988;1(1):4
N(alpha)-dimethylcoprogen  117892-97-4   *Hydroxamic Acids Siderophores. Biol Met 1988;1(1):4
amonabactin P  120919-03-1   *Oligopeptides Siderophores. Biol Met 1989;2(3):155
amonabactin T  120919-04-2   *Oligopeptides Siderophores. Biol Met 1989;2(3):155
staphyloferrin A  127902-98-1 Butanedioic acid, 2,2'-((1-carboxy-1,4-butanediyl)bis(imino(2-oxo-2,1-ethanediyl)))bis(2-hydroxy)  *Citrates Ornithine/*analogs & derivatives Siderophores. FEMS Microbiol Lett 1990;55(1-2):201
myxochelin A  120243-02-9 Benzamide, N,N'-(1-(hydroxymethyl)-1,5-pentanediyl)bis(2,3-dihydroxy)  Lysine/*analogs & derivatives Siderophores. J Antibiot (Tokyo) 1989;42(1):14
chrysobactin  120124-51-8 L-Serine, N-(N2-(2,3-dihydroxybenzoyl)-D-lysyl)  *Dipeptides Siderophores. J Biol Chem 1989;264(5):3187
desferricoprogen  100811-54-9   *Hydroxamic Acids *Diketopiperazines Siderophores. J Bacteriol 1986;165(1):283
corynebactin  95536-41-7   Enterobactin/*analogs & derivatives Corynebacterium diphtheriae Siderophores. Infect Immun 1985;47(2):575
pseudobactin 7SR1  90295-72-0   *Oligopeptides Siderophores. Biochemistry 1984;23(15):3534
azotobactin  39748-05-5 Aspartic acid, N-(N-(N-(N5-(aminocarbonyl)-N2-(N-(N-(N-(N-((2,3,4,5-tetrahydro-8-hydroxy-4,9-dioxo-1H,9H-3a,5,10b-triazaacephenanthrylen-1-yl)carbonyl)-alpha-aspartyl)homoseryl)seryl)homoseryl)ornithyl)seryl)glycyl)-3-hydroxy  *Peptides Siderophores. J Bacteriol 1984;159(1):341
azotochelin  23369-85-9 L-Lysine, N2,N6-bis(2,3-dihydroxybenzoyl)  Lysine/*analogs & derivatives Siderophores. J Bacteriol 1984;159(1):341
isotriornicine  81559-22-0 L-Ornithine, N2-acetyl-N5-hydroxy-N5-(5-hydroxy-3-methyl-1-oxo-2-pentenyl)-, 5-((3-(5-(3-(acetylhydroxyamino)propyl)-3,6-dioxo-2-piperazinyl)propyl)hydroxyamino)-3-methyl-5-oxo-3-pentenyl ester, (2S-(2alpha(E(E)),5alpha))  *Hydroxamic Acids Siderophores. Biochem Biophys Res Commun 1982;105(1):133
deferrioxamine E  26605-16-3   *Peptides, Cyclic Siderophores. J Bacteriol 1982;149(1):381
pseudobactin A  79438-64-5 L-Alaninamide, N6-((5-((4-amino-1,4-dioxobutyl)amino)-2,3,5,6-tetrahydro-8,9-dihydroxy-1H-pyrimido(1,2-a)quinolin-1-yl)carbonyl)-L-lysyl-threo-3-hydroxy-D-alpha-aspartyl-L-alanyl-D-allothreonyl-N-(1-hydroxy-2-oxo-3-piperidinyl)  *Oligopeptides Siderophores. Biochemistry 1981;20(22):6457
ferrichrome A  15258-80-7   Ferrichrome/*analogs & derivatives Siderophores. Infect Immun 1981;32(2):609
gonobactin  78170-58-8 Gonobactin  *Hydroxamic Acids Siderophores. Infect Immun 1981;32(2):600
meningobactin  78170-67-9 Meningobactin  *Hydroxamic Acids Siderophores. Infect Immun 1981;32(2):600
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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