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Janus Kinase 3

More information in Books or onNLM PubMed
Definition: A Janus kinase subtype that is predominantly expressed in hematopoietic cell. It is involved in signaling from a broad variety of CYTOKINE RECEPTORS including ones that utilize the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT.      Other names Kinase 3, Janus; JAK 3 Protein Tyrosine Kinase; JAK3 Protein Tyrosine Kinase; JAK-3 Protein Tyrosine Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione  0   *Indoles *Maleimides Janus Kinase 3/antagonists & inhibitors. J Med Chem 2011 Jan 13;54(1):284-8
PF 956980  0   *Pyrimidines *Pyrroles Janus Kinase 3/antagonists & inhibitors. Blood 2008 Feb 15;111(4):2155-7
10,13-dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one  0   *Diterpenes *Purines Janus Kinase 3/antagonists & inhibitors. Mol Cancer 2010;9:36
Nb-(alpha-hydroxynaphthoyl)serotonin  0   *Naphthols Serotonin/*analogs & derivatives Janus Kinase 3/antagonists & inhibitors. Br J Haematol 2010 Jan;148(1):132-43
Jak3 protein, rat  0   *Janus Kinase 3.
Jak3 protein, mouse  EC 2.7.1.112   *Janus Kinase 3.
JAK3 protein, human  0   *Janus Kinase 3.
tofacitinib  0   *Pyrimidines *Pyrroles Janus Kinase 3/antagonists & inhibitors. Science 2003 Oct 31;302(5646):875-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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