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Pore Forming Cytotoxic Proteins

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Definition: Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.     
See Also Porins
Examples Antimicrobial Cationic Peptides; Bacteriocins; Gramicidin; Hemolysin Proteins; Leukocidins; Perforin; Streptolysins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PRX302  0   *Bacterial Toxins *Pore Forming Cytotoxic Proteins. J Natl Cancer Inst 2007 Mar 7;99(5):376-85
perforin 2  0   *Pore Forming Cytotoxic Proteins T-Lymphocytes, Cytotoxic.
PRF1 protein, human  0   *Pore Forming Cytotoxic Proteins T-Lymphocytes, Cytotoxic.
perforin 1, mouse  0   *Pore Forming Cytotoxic Proteins T-Lymphocytes, Cytotoxic.
perforin, rat  0   *Pore Forming Cytotoxic Proteins T-Lymphocytes, Cytotoxic.
perforin, mouse  0   *Pore Forming Cytotoxic Proteins. Biochem Biophys Res Commun 2004 Apr 2;316(2):468-75
hydralysin  0   *Pore Forming Cytotoxic Proteins Cnidarian Venoms. Biochemistry. 2003 Aug 5;42(30):8939-44
PopB protein, Ralstonia solanacearum  0   *Bacterial Proteins *Pore Forming Cytotoxic Proteins. Mol Microbiol 2000 Apr;36(2) 261-77
sticholysin II  0   *Cnidarian Venoms Sea Anemones Pore Forming Cytotoxic Proteins. Protein Expr Purif 2000 Feb;18(1):71-6
stycholysin I  0   Organic Chemicals Pore Forming Cytotoxic Proteins. J Protein Chem 1999 Apr;18(3):
antigen V, Pseudomonas  0   *Antigens, Bacterial *Bacterial Toxins *Pore Forming Cytotoxic Proteins. Nat Med 1999 Apr;5(4):392-8
proaerolysin  0   *Bacterial Toxins *Pore Forming Cytotoxic Proteins. Protein Eng 1997 Mar;10(3):207-15
LcrG protein, Yersinia  0   *Bacterial Proteins *Pore Forming Cytotoxic Proteins. J Bacteriol 1994 Jul;176(13):3878-84
LcrV protein, Yersinia  0   *Antigens, Bacterial *Pore Forming Cytotoxic Proteins. J Bacteriol 1984;160(3):842
aerolysin  53126-24-2   *Bacterial Toxins *Pore Forming Cytotoxic Proteins. Can J Biochem 1981;59(6):430; FEBS Lett. 2003 Aug 14;549(1-3):47-51

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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