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Proto-Oncogene Proteins c-mdm2

More information in Books or onNLM PubMed
Definition: An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF.      Other names c-mdm2, Proto-Oncogene Proteins; c mdm2 Proto Oncogene Protein; Proto-Oncogene Protein, c-mdm2; Proto Oncogene Proteins c mdm2; Mdm 2 Protein; Murine Double Minute 2 Protein; Mdm-2 Protein; MDMX Protein; Double Minute 2 Protein; c-mdm2 Proto-Oncogene Protein; Mdm2 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MI-291  0   *Indoles *Spiro Compounds Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors. Curr Cancer Drug Targets. 2010 May;10(3):319-31
MI 319  0   *Indoles *Spiro Compounds Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors. Mol Cancer 2009;8:115
Xdm2 protein, Xenopus  EC 6.3.2.19   *Xenopus Proteins *Proto-Oncogene Proteins c-mdm2.
mdm2 protein, zebrafish  EC 6.3.2.19   *Zebrafish Proteins *Proto-Oncogene Proteins c-mdm2.
Mdm2 protein, rat  EC 6.3.2.19   *Proto-Oncogene Proteins c-mdm2.
Mdm2 protein, mouse  EC 6.3.2.19   *Proto-Oncogene Proteins c-mdm2.
MDM2 protein, human  EC 6.3.2.19   *Proto-Oncogene Proteins c-mdm2.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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