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Receptor, Adenosine A2B

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Definition: A subclass of adenosine A2 receptors found in the CECUM, the COLON, the BLADDER, and a variety of other tissues. It is generally considered to be a low affinity receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.      Other names Receptors, Adenosine A2B; A2B Receptors, Adenosine; A2B Receptor, Adenosine; Adenosine A2B Receptors; Adenosine A(2B) Receptor; Adenosine A2B Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
adora2b protein, zebrafish  0   *Zebrafish Proteins *Receptor, Adenosine A2B. Gene Expr Patterns 2009 Mar;9(3):144-51
4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine  0   *Furans *Pyrimidines Receptor, Adenosine A2B/antagonists & inhibitors. J Med Chem 2007 May 31;50(11):2732-6
2-(3''-(6''-bromoindolyl)ethyloxy)adenosine  0   Adenosine/*analogs & derivatives Receptor, Adenosine A2B/agonists. J Med Chem 2007 Apr 19;50(8):1810-27
BAY 60-6583  0   *Aminopyridines Receptor, Adenosine A2B/agonists. Circulation 2007 Mar 27;115(12):1581-90
1-propyl-8-(4-sulfophenyl)xanthine  0   *Xanthines Receptor, Adenosine A2B/antagonists & inhibitors. J Med Chem 2004 Feb 12;47(4):1031-43
N(epsilon)-thioacetyllysine  0   Lysine/*analogs & derivatives Receptor, Adenosine A2B. Bioorg Med Chem Lett 2006 Jul 15;16(14):3651-6
8-(4-(4-benzylpiperazide-1-sulfonyl)phenyl)-1-propylxanthine  0   *Sulfonamides *Xanthines Receptor, Adenosine A2B/antagonists & inhibitors. J Med Chem 2006 Jul 13;49(14):4384-91
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dimethylxanthine  0   *Pyrazoles Theophylline/*analogs & derivatives Receptor, Adenosine A2B/antagonists & inhibitors. J Med Chem 2006 Jun 15;49(12):3682-92
N-(4-acetylphenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy)acetamide  0   *Purines Receptor, Adenosine A2B/antagonists & inhibitors.
2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile  0   *Aminopyridines *Imidazoles Receptor, Adenosine A2B/agonists. J Med Chem 2004 Jul 15;47(15):3707-9
N-(2-(2-phenyl-6-(4-(3-phenylpropyl)piperazine-1-carbonyl)-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)ethyl)acetamide  0   *Pyrroles *Pyrimidines Ligands Tritium Receptor, Adenosine A2B/antagonists & inhibitors. Biochem Pharmacol 2004 Jul 15;68(2):305-12

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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