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Phosphoribosylglycinamide Formyltransferase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the transfer of a formyl group from N10-formyltetrahydrofolate to N1-(5-phospho-D-ribosyl)glycinamide to yield N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and tetrahydrofolate. It plays a role in the de novo purine biosynthetic pathway.      Other names GARTFase; Transformylase, Glycinamideribotide; Transformylase, Glycinamide Ribonucleotide; Transformylase, GAR; Transformylase, 5'-Phosphoribosylglycinamide; Transformylase, 2-Amino-N-Ribosylacetamide 5'-Phos; Ribonucleotide Transformylase, Glycinamide; Formyltransferase, Phosphoribosylglycinamide; Formyltransferase, GAR; 5'-Phosphate Transformylase, 2-Amino-N-Ribosylacet; 5' Phosphoribosylglycinamide Transformylase; 2 Amino N Ribosylacetamide 5' Phosphate Transformy; Glycinamideribotide Transformylase; Glycinamide Ribonucleotide Transformylase; GAR Transformylase; GAR Formyltransferase; 5'-Phosphoribosylglycinamide Transformylase; 2-Amino-N-Ribosylacetamide 5'-Phosphate Transformy
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gart protein, zebrafish  EC 2.1.2.2   *Zebrafish Proteins *Phosphoribosylglycinamide Formyltransferase. Development. 2009 Aug;136(15); 2601-11
2-(4-(6-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl)benzamido)-4-(1H-tetrazol-5-yl)butanoic acid  0   *Aminobutyric Acids *Pyrimidinones Phosphoribosylglycinamide Formyltransferase/antagonists & inhibitors. J Med Chem 2006 May 18;49(10):2998-3002
GART protein, human  EC 6.3.4.13   *Carbon-Nitrogen Ligases *Phosphoribosylglycinamide Formyltransferase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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