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Formate-Tetrahydrofolate Ligase

More information in Books or onNLM PubMed
Definition: A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.     
See Also Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP) 		Other names Tetrahydrofolate Formylase; Synthetase, Formyltetrahydrofolate; Ligase, Formate-Tetrahydrofolate; Formylase, Tetrahydrofolate; Formate Tetrahydrofolate Ligase; Formyltetrahydrofolate Synthetase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
formyl-methenyl-methylenetetrahydrofolate synthetase  73699-18-0 Synthetase, formyl-methenyl-methylenetetrahydrofolate  *Aminohydrolases *Formate-Tetrahydrofolate Ligase *Methylenetetrahydrofolate Dehydrogenase (NADP) *Multienzyme Complexes. Adv Exp Med Biol 1983;163;75; Biochem Biophys Res Commun 77(1):147;1977; J Biol Chem 1980;255(6):2569; J Biol Chem 251(16):5104;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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