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Eukaryotic Initiation Factors

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Definition: Peptide initiation factors from eukaryotic organisms. Over twelve factors are involved in PEPTIDE CHAIN INITIATION, TRANSLATIONAL in eukaryotic cells. Many of these factors play a role in controlling the rate of MRNA TRANSLATION.  general or unspecified; prefer specifics; coordinate with MITOCHONDRIAL PROTEINS or CHLOROPLAST PROTEINS if pertinent   
Examples Eukaryotic Initiation Factor-1; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-2B; Eukaryotic Initiation Factor-3; Eukaryotic Initiation Factor-4F; Eukaryotic Initiation Factor-5 		Other names Initiation Factors, Eukaryotic; Eukaryotic Peptide Initiation Factors; Translation Initiation Factors, Eukaryotic; Peptide Initiation Factors, Eukaryotic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IFE-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Eukaryotic Initiation Factors RNA Cap-Binding Proteins. Mol Cells 2011 Feb;31(2):191-7
DRR-2 protein, C elegans  0   *Caenorhabditis elegans Proteins *Eukaryotic Initiation Factors. Aging Cell 2010 Aug;9(4):545-57
Eif2c1 protein, mouse  0   *Eukaryotic Initiation Factors *Argonaute Proteins. Dev Dyn 2010 Feb;239(2):407-24
HCF173 protein, Arabidopsis  0   *Arabidopsis Proteins *Eukaryotic Initiation Factors. Plant Cell 2007 Apr;19(4):1329-46
eIF6 protein, C elegans  0   *Caenorhabditis elegans Proteins *Eukaryotic Initiation Factors. Nature 2007 Jun 14;447(7146):823-8
MTIF3 protein, human  0   *Mitochondrial Proteins *Eukaryotic Initiation Factors. Neurosci Lett. 2007 Mar 6;414(2):126-9
EIF2C4 protein, human  0   *Eukaryotic Initiation Factors *Argonaute Proteins. Arthritis Res Ther 2006;8(4):R87
eIF(iso)4E protein, Arabidopsis  0   *Arabidopsis Proteins *Eukaryotic Initiation Factors RNA Cap-Binding Proteins. Curr Biol 2002 Jun 25;12(12):1046-51
Eif4ebp1 protein, mouse  0   *Carrier Proteins *Phosphoproteins Repressor Proteins Eukaryotic Initiation Factors.
Eif4ebp1 protein, rat  0   *Carrier Proteins *Phosphoproteins Repressor Proteins Eukaryotic Initiation Factors.
Eif4ebp2 protein, mouse  0   *Eukaryotic Initiation Factors Peptide Initiation Factors.
MTIF2 protein, human  0   *Mitochondrial Proteins *Eukaryotic Initiation Factors.
COPS6 protein, human  0   *Carrier Proteins *Eukaryotic Initiation Factors. J Biol Chem 2002 Dec 6;277(49):47854-60
eukaryotic initiation factor-5B  0   *Eukaryotic Initiation Factors Prokaryotic Initiation Factor-2.
IFM1 protein, S cerevisiae  0   *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins *Eukaryotic Initiation Factors.
EIF1 protein, human  0   *Neoplasm Proteins *Nerve Tissue Proteins *Eukaryotic Initiation Factors Okadaic Acid. J Biomed Sci 2000 Mar-Apr;7(2):152-9
Moe1 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *Eukaryotic Initiation Factors. Proc Natl Acad Sci U S A 1999 Jan 19;96(2):517-22
EIF2C1 protein, human  0   *Eukaryotic Initiation Factors *Argonaute Proteins.
DENR protein, human  0   *Eukaryotic Initiation Factors. DNA Cell Biol 1998 May;17(5):437-47
EIF4H protein, human  0   *Eukaryotic Initiation Factors. J Biol Chem 1998 Mar 27;273(13):7579-87
EIF6 protein, human  0   *Eukaryotic Initiation Factors Peptide Initiation Factors. J Biol Chem 1997 Nov 28;272(48):30314-21; Mol Cell Biol 2003 Sep;23(17):6187-99
EIF4EBP2 protein, human  0   *Eukaryotic Initiation Factors Peptide Initiation Factors. Genomics 1996 Dec 15;38(3):353-63
EIF4EBP1 protein, human  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing Repressor Proteins Eukaryotic Initiation Factors. Proc Natl Acad Sci U S A 1994 Apr 26;91(9):3730-4
TIF3 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Eukaryotic Initiation Factors. EMBO J 1993 Oct;12(10):3997-4003
eIF-4B  0   *Eukaryotic Initiation Factors. FEBS Lett 1981;129(1):62

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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