Definition: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Other names c-bcl-2, Proto-Oncogene Proteins; c bcl 2 Proteins; bcl 2 Proto Oncogene Proteins; Proto-Oncogene Proteins, bcl-2; Proto Oncogene Proteins c bcl 2; B Cell Leukemia 2 Family Proteins; B-Cell Leukemia 2 Family Proteins; bcl-2 Proto-Oncogene Proteins; c-bcl-2 Proteins