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beta-lapachone
under Naphthoquinones
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Naphthoquinones
Definition
: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Other names
Naphthazarins; Naphthalenediones
Substance
CAS Registry & name
Categories
Source
Drugs
*
beta-lapachone [ ARQ 501 ]
inhibitor of reverse transcriptase & DNA polymerase; structure; inhibitor of DNA topoisomerase
4707-32-8 3,4-
dihydro-
2,2-
dimethyl-
2H-
naphtho(1,2-
b)pyran-
5,6-
dione
*Naphthoquinones
Pharma Action
Anti-Infective Agents
;
Radiation-Sensitizing Agents
;
Reverse Transcriptase Inhibitors
An Acad Bras Cienc 50(4):598;1978; Ann Trop Med Parasitol 72(6):523;1978; Antimicrob Agents Chemother 14(4):630; Arch Biochem Biophys 186(2):292;1978; Biochem J 175(2):431;1978; Eur J Biochem 84:197;1978; Exp Parasitol 42:142;1977; Lancet 2(8101):1190;1978