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Receptors, Leukotriene B4

More information in Books or onNLM PubMed
Definition: A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation influences chemotaxis, chemokinesis, adherence, enzyme release, oxidative bursts, and degranulation in polymorphonuclear leukocytes. There are at least two subtypes of these receptors. Some actions are mediated through the inositol phosphate and diacylglycerol second messenger systems.  DF: RECEPT LEUKOTRIENE B4    Other names Leukotriene B4 Receptors; LTB4 Receptors; Receptors, LTB4; Receptor, Leukotriene B4; Receptor, LTB4; Leukotriene B4 Receptor; LTB4 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(3-(6-(3-benzo(1,3)dioxol-5-yl-5-thiophen-3-ylphenoxy)hexyl)-2-(2-carboxyethyl)phenoxy)butyric acid  0   *Phenylpropionates *Benzodioxoles Receptors, Leukotriene B4/antagonists & inhibitors. Prostaglandins Other Lipid Mediat 2010 Jun;92(1-4):33-43
4-(5-(4-(aminoiminomethyl)phenoxy)5,4pentyloxy)-3-methoxy-N,N,-bis(1-methylethyl)benzamide-2-butenedionate  0   *Benzamides Receptors, Leukotriene B4/antagonists & inhibitors. Pulm Pharmacol Ther. 2008;21(2):409-17
Ltb4r protein, rat  0   *Receptors, Leukotriene B4.
LTB4R protein, human  0   *Receptors, Leukotriene B4 Leukotriene B4.
Ltb4r1 protein, mouse  0   *Receptors, Leukotriene B4. Brain Res Mol Brain Res 2005 Jun 13;137(1-2):263-6
2-(2-morpholinocarbo-1-methylvinyl)-7-ethoxycarbopropoxybenzo(b)furan  0   *Benzofurans *Morpholines Receptors, Leukotriene B4/antagonists & inhibitors. Org Biomol Chem 2004 Dec 7;2(23):3427-31
2-acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo(b)furan  0   *Benzofurans *Carbamates Receptors, Leukotriene B4/antagonists & inhibitors. Org Biomol Chem 2004 Dec 7;2(23):3427-31
LTB4R2 protein, human  0   *Receptors, Leukotriene B4 Leukotriene B4.
amelubant  0   *Amidines *Carbamates Receptors, Leukotriene B4/antagonists & inhibitors. J Pharmacol Exp Ther 2001 Apr;297(1):458-66
Ltb4r2 protein, mouse  0   *Receptors, Leukotriene B4 Leukotriene B4. J Biol Chem 2000 Sep 1;275(35):27000-4; J Exp Med 2000 Aug 7;192(3):421-32
Ro 0254094  0   *Benzopyrans Receptors, Leukotriene B4/antagonists & inhibitors. Eur J Pharmacol 1998 Nov 13;361(1):93-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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