encyclopedia of medical concepts
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Paclitaxel
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Definition
: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Pharmacological Action
Antineoplastic Agents, Phytogenic
;
Tubulin Modulators
Other names
NSC125973; NSC 125973; 7 epi Taxol; Taxol A; Praxel; Paxene; Paclitaxel, (4 alpha)-
Isomer; NSC-
125973; Lemery Brand of Paclitaxel; Ivax Brand of Paclitaxel; Bull Brand of Paclitaxel; Bristol-
Myers Squibb Brand of Paclitaxel; Bristol-
Myers Brand of Paclitaxel; Bris Taxol; Anzatax; 7-
epi-
Taxol; Onxol; Taxol
Drugs
*
:
PACLITAXEL
;
TAXOL
Substance
CAS Registry & name
Categories
Source
Drugs
*
MP 265
0
Gonadotropin-Releasing Hormone/*analogs & derivatives
Paclitaxel/*analogs & derivatives.
Int J Pharm. 2011 Aug 30;415(1-2):175-80.
MP 264
0
Gonadotropin-Releasing Hormone/*analogs & derivatives
Paclitaxel/*analogs & derivatives.
Int J Pharm 2011 Aug 30;415(1-2):175-80
ONCOFID-
P
0
Hyaluronic Acid/*analogs & derivatives
Paclitaxel/*analogs & derivatives.
Cancer Chemother Pharmacol 2011 Jul;68(1):107-16
poly(gamma-
glutamylglutamine)paclitaxel
0
*Proteins
Paclitaxel/*analogs & derivatives.
Cancer Chemother Pharmacol 2010 Apr;65(5):923-30
PET regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Epirubicin
Paclitaxel.
Ann Oncol 2009 Jul;20(7):1185-92
HPMA copolymer-
PTX-
FK-
ALN conjugate
0
*Acrylamides
Paclitaxel/*analogs & derivatives
Polymers.
Angew Chem Int Ed Engl. 2009;48(16):2949-54
cyclotriphosphazene-
paclitaxel conjugate
0
*Organophosphorus Compounds
Paclitaxel/*analogs & derivatives.
Bioorg Med Chem Lett 2008 Dec 15;18(24):6410-3
(14)C-
CNDR-
29
0
Paclitaxel/*analogs & derivatives.
Bioorg Med Chem Lett 2008 Dec 1;18(23):6119-21
10-
O-
acetyl-
5'-
hydroxybutitaxel
0
Paclitaxel/*analogs & derivatives.
Bioorg Med Chem Lett 2008 Dec 1;18(23):6165-7
paclitaxel 2'-
ethylcarbonate
0
Paclitaxel/*analogs & derivatives.
Biopharm Drug Dispos 2008 Jul;29(5):259-69
Lx2-
32c compound
0
Paclitaxel/*analogs & derivatives.
Cancer Lett 2008 Sep 8;268(1):89-97
paclitaxel-
Angiopep-
2 conjugate
0
*Paclitaxel.
Br J Pharmacol 2008 Sep;155(2):185-97
7-
xylosyl-
10-
deacetylpaclitaxel
0
Paclitaxel/*analogs & derivatives.
Int J Oncol 2008 Jul;33(1):103-11
docosahexaenoyl-
paclitaxel
0
Paclitaxel/*analogs & derivatives.
J Control Release 2001 Jul 6;74(1-3):233-6
4-
fluoropaclitaxel
0
Paclitaxel/*analogs & derivatives
Fluorine Radioisotopes.
Nucl Med Biol 2007 Oct;34(7):823-31
paclitaxel-
EC-
1 conjugate
0
*Peptides, Cyclic
Paclitaxel/*analogs & derivatives.
Biopolymers 2007 Nov;87(4):225-30
AI-
850
0
*Paclitaxel.
Clin Cancer Res 2007 Jun 1;13(11):3293-301
130-
nm albumin-
bound paclitaxel
0
*Albumins
*Paclitaxel.
Clin Cancer Res 2007 Mar 15;13(6):1868-74
10-
succinyl paclitaxel
0
Paclitaxel/*analogs & derivatives.
Eur J Pharmacol 2007 May 7;562(1-2):20-7
AZ 10992
0
*Dextrans
Paclitaxel/*analogs & derivatives.
J Control Release 2007 Jan 22;117(1):40-50
2'-
paclitaxel methyl 2-
glucopyranosyl succinate
0
*Succinates
Paclitaxel/*analogs & derivatives.
Bioorg Med Chem Lett. 2007 Feb 1;17(3):617-20
MBT-
0206
0
*Lipids
*Paclitaxel.
Cancer Biol Ther 2006 Jan;5(1):89-96
paclitaxel poliglumex
0
Polyglutamic Acid/*analogs & derivatives
Paclitaxel/*analogs & derivatives.
Clin Cancer Res 2005 Nov 1;11(21):7834-40
6,6,8-
trimethyl-
4,4a,5,6,7,7a,8,9-
octahydrocyclopenta(4,5)cyclohepta(1,2-
c)-
furan-
4,8-
diol 4-
(N-
acetyl-
3-
phenylisoserinate)
0
Paclitaxel/*analogs & derivatives.
Anticancer Drugs 2005 Aug;16(7):777-88
6,6,8-
trimethyl-
4,4a,5,6,7,7a,8,9-
octahydrocyclopenta(4,5)cyclohepta(1,2-
c)-
furan-
4,8-
diol 4-
(N-
tert-
butoxycarbonyl-
3-
phenylisoserinate)
0
Paclitaxel/*analogs & derivatives.
Anticancer Drugs 2005 Aug;16(7):777-88
10-
deacetoxy-
7-
deoxypaclitaxel
0
Paclitaxel/*analogs & derivatives.
Bioorg Med Chem Lett 2006 Jan 15;16(2):433-6
7-
deoxypaclitaxel
0
Paclitaxel/*analogs & derivatives.
Bioorg Med Chem Lett 2006 Jan 15;16(2):433-6
NK105
0
Paclitaxel/*analogs & derivatives.
Br J Cancer. 2005 Apr 11;92(7):1240-6
AT protocol
0
Doxorubicin
*Antineoplastic Combined Chemotherapy Protocols
Paclitaxel.
J Clin Oncol 2005 Jan 20;23(3):432-40
10-
O-
deacetylpaclitaxel 10-
monosuccinyl ester
0
Paclitaxel/*analogs & derivatives.
J Med Chem 2005 Feb 10;48(3):832-8
1-
deoxypaclitaxel
0
Paclitaxel/*analogs & derivatives.
J Org Chem 2005 Jan 7;70(1):315-20
3'-
(4-
azidophenyl)-
3'-
dephenylpaclitaxel
0
*Azides
Paclitaxel/*analogs & derivatives.
J Med Chem 2004 Dec 16;47(26):6459-65
Pacliex
0
Paclitaxel/*analogs & derivatives.
Cancer Chemother Pharmacol. 2005 Jan;55(1):47-54
12b-
acetyloxy-
2a,3,4,4a,5,6,9,10,11,12,12a,12b-
dodecahydro-
4,11-
dihydroxy-
12-
(2,5-
dimethoxybenzyloxy)-
4a,8,13,13-
tetramethyl-
5-
oxo-
7,11-
methano-
1H-
cyclodeca(3,4)benz(1,2-
b)oxet-
9-
yl 3-
(tert-
butyloxycarbonyl)amino-
2-
hydroxy-
5-
methyl-
4-
hexaenoate
0
Paclitaxel/*analogs & derivatives.
J Med Chem 2004 Sep 23;47(20):4802-5
7-
(3-
methyl-
3-
nitrosothiobutyryl)paclitaxel
0
*Nitroso Compounds
Paclitaxel/*analogs & derivatives.
J Med Chem 2004 Apr 22;47(9):2276-82
polilactofate
0
*Paclitaxel
Microspheres.
Clin Cancer Res 2003 Aug 15;9(9):3441-7
7-
succinylpaclitaxel
0
Paclitaxel/*analogs & derivatives.
Eur J Med Chem. 2003 Apr;38(4):383-9
A-
Z-
CINN 310
0
Paclitaxel/*analogs & derivatives.
J Exp Ther Oncol. 2003 Jan-Feb;3(1):27-35
TXD 258
0
Paclitaxel/*analogs & derivatives.
Br J Pharmacol 2003 Apr;138(7):1367-75
MAC321
0
Paclitaxel/*analogs & derivatives.
Mol Cancer Ther 2003 Sep;2(9):873-84
isotaxel
0
Paclitaxel/*analogs & derivatives.
J Med Chem 2003 Aug 28;46(18):3782-4
TCF protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Fluorouracil
Paclitaxel/*analogs & derivatives.
Tumori. 2003 Jul-Aug;89(4 Suppl):66
albumin-
bound paclitaxel
0
*Paclitaxel
Albumins.
Clin Cancer Res 2002 May;8(5):1038-44
ABRAXANE
ET protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Epirubicin
Paclitaxel.
J Clin Oncol 2001 Apr 15;19(8):2222-31
PC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Carboplatin
Paclitaxel.
Gynecol Oncol. 2000 Nov;79(2):196-200
1,7-
dihydroxytaxinine
0
*Bridged Compounds
*Taxoids
Alkaloids
Paclitaxel.
Biosci Biotechnol Biochem 2000 Apr;64(4):894-8