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Tetrahydrofolate Dehydrogenase

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Definition: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.      Other names Folic Acid Reductase; Dihydrofolate Reductase; Dihydrofolate Dehydrogenase; Reductase, Folic Acid; Reductase, Dihydrofolate; Dehydrogenase, Tetrahydrofolate; Dehydrogenase, Dihydrofolate; Acid Reductase, Folic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(4-((2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)thio)benzoyl)glutamic acid  0   *Glutamates *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7215-22
N-(4-((2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)thio)benzoyl)glutamic acid  0   *Glutamates *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7215-22
2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylthio)pyrrolo(2,3-d)pyrimidine  0   *Pyrimidines *Sulfides Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 2004 Jul 1;47(14):3689-92
2,4-diamino-6-(2'-O-(3-carboxypropyl)oxydibenz(b,f)azepin-5-yl)methylpteridine  0   *Benzazepines *Pteridines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 2004 May 6;47(10):2475-85
BW 2315  0   *Sulfonamides *Tetrahydrofolates Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Biol Chem 2004 Apr 23;279(17):18034-45
BW 1540  0   *Sulfonamides *Tetrahydrofolates Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Biol Chem 2004 Apr 23;279(17):18034-45
2,4-diamino-5-(2'-(4-carboxyphenyl)ethynyl)-5'-(methoxybenzyl)pyrimidine  0   *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1475-86
FolM protein, E coli  EC 1.5.1.3   *Tetrahydrofolate Dehydrogenase *Escherichia coli Proteins. J Bacteriol 2003 Dec;185(23):7015-8
2,4-diamino-6-((3',4',5'-trichloroanilino)methyl)pyrido(2,3-d)pyrimidine  0   *Pyridines *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 2003 Nov 6;46(23):5074-82
2,4-diamino-6-((2',5'-dichloroanilino)methyl)pyrido(2,3-d)pyrimidine  0   *Pyridines *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 2003 Nov 6;46(23):5074-82
N-(4-((2,4-diaminoquinazoline-6-yl)methylene)oxycarbonyl)benzoyl glutamic acid  0   *Quinazolines Glutamic Acid/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 2003 Jul 31;46(16):3455-62
N-(2-amino-4-ethyl-6-methyl((pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)glutamic acid  0   *Pyrimidines Glutamic Acid/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Med Chem 2003 Feb 13;46(4):591-600
N-(2-amino-4-ethyl((pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)glutamic acid  0   *Pyrimidines Glutamic Acid/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Med Chem 2003 Feb 13;46(4):591-600
N-((2,4-diaminopteridin-6-yl)methyl)dibenz(b,f)azepine  0   *Azepines *Pteridines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1999 Nov 18;42(23):4853-60
2,4-diamino-6-(N-(2',5'-dimethoxybenzyl)-N-methylamino)pyrido(2,3-d)pyrimidine  0   *Pyridines *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1998 Aug 27;41(18):3426-34
DHFR-ASC  0   *Tetrahydrofolate Dehydrogenase. Anal Chem 1998 May 15;70(10):2019-24
2,4-diamino-5,6,7,8-tetrahydro-7-(4'-benzoylglutamic acid)pyrido(4',3'-4,5)furo(2,3-d)pyrimidine  0   *Pyrimidines Glutamic Acid/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1998 Apr 23;41(9):1409-16
2,4-diamino-5-((3,5-dichloro-4-(1-pyrrolo)anilino)methyl)-6-bromothieno(2,3-d)pyrimidine  0   *Pyrimidines *Thiophenes Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1997 Oct 24;40(22):3694-9
2,4-diamino-5-(3-(3-(2-(acetyloxy)ethyl)-3-benzyltriazen-1-yl)-4-chlorophenyl)-6-ethylpyrimidine  0   *Pyrimidines *Triazenes Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1886-93
dihydrofolate reductase type II  EC 1.5.1.-   *Tetrahydrofolate Dehydrogenase. EMBO J 1996 Mar 15;15(6):1203-10
2,4-diamino-6-((3',4',5'-trimethoxy-N-methylanilino)methyl)pyrido(3,2-d)pyrimidine  0   *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1995 Jul 7;38(14):2615-20
Phytodolor N  141444-11-3   *Plant Extracts Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Arzneimittelforschung 1995 Feb;45(2):169-71
gamma-methylene-10-ethyl-10-deazaaminopterin  0   Aminopterin/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Adv Exp Med Biol 1993;338:663-6
gamma-methylene-10-deazaaminopterin  0   Aminopterin/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Adv Exp Med Biol 1993;338:663-6
N-((5-(2,4-diamino-6-pteridinyl)ethyl)-2-thenoyl)glutamic acid  0   *Glutamates *Pterins Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Adv Exp Med Biol 1993;338:421-4
ethylbenzoprim  118344-72-2   *Aniline Compounds *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Anticancer Drug Des 1992 Dec;7(6):443-9
dihydrofolate reductase type IIIb  EC 1.5.1.-   *Tetrahydrofolate Dehydrogenase. J Gen Microbiol 1990;136(Pt 4):673
methylbenzoprim  118344-71-1 2,4-Pyrimidinediamine, 6-ethyl-5-(4-(methyl(phenylmethyl)amino)-3-nitrophenyl)  *Pyrimidines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Anticancer Drug Des 1990;5(2):201
2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine  113494-35-2   Pyrimethamine/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. FEBS Lett 1988;240(1-2):201
thymidylate synthase-dihydrofolate reductase  0   *Multienzyme Complexes *Tetrahydrofolate Dehydrogenase *Thymidylate Synthase. Biochemistry 1988;27(10):3776
3-azidopyrimethamine  95458-40-5   *Azides Pyrimethamine/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Anticancer Drug Des 1987;2(3):297
(N-(4-amino-4-deoxy-N(10)-methylpteroyl)amino)-3-chloro-4,5-dihydro-5-isoxazoleacetic acid  108743-20-0   *Isoxazoles Methotrexate/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1987;30(8):1463
aditoprim  56066-63-8   Trimethoprim/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Chromatogr 1986;383(1):111
4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-phenylthiomethylphenyl)-1,3,5-triazine  87739-93-3   *Triazines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Biochim Biophys Acta 1986;869(3):275
M&B 35769  0   Pyrimethamine/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Am J Trop Med Hyg 1984;33(5):772
5-deazaaminopterin  80360-09-4 L-Glutamic acid, N-(4-(((2,4-diaminopyrido(2,3-d)pyrimidin-6-yl)methyl)amino)benzoyl)  Aminopterin/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1984;33(2);175
5-deazafolic acid  85597-17-7 L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)methyl)amino)benzoyl)  Folic Acid/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1984;33(2):175
5-deazamethotrexate  0   Methotrexate/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. Biochem Pharmacol 1984;33(2):175
2'-fluoroaminopterin  85803-29-8   Aminopterin/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1983;26(8):1193
3'-fluoroaminopterin  85803-34-5   Aminopterin/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1983;26(8):1193
fluoresceinated methotrexate  0   Methotrexate/*analogs & derivatives Tetrahydrofolate Dehydrogenase. J Biol Chem 1982;257(23):14162
lysine-iodoacetylmethotrexate  82339-36-4 L-Lysine, N2-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-N6-(iodoacetyl)  Methotrexate/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Med Chem 1982;25(8):960
2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine  21316-30-3   *Triazines Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Biol Chem 1982;257(5):2528
R388  0   *Tetrahydrofolate Dehydrogenase. Biochem Biophys Res Commun 58(2):412;1974

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