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Sphingomyelin Phosphodiesterase
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Definition
: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
/defic: consider also NIEMANN-PICK DISEASE
See Also
Niemann-Pick Diseases
Other names
Sphingomyelinase C; Sphingomyelinase; Sphingomyelin Cleaving Enzyme; Sphingomyelin Cholinephosphohydrolase
Substance
CAS Registry & name
Categories
Source
Drugs
*
RY221B-
a
0
Sphingosine/*analogs & derivatives
2,2'-Dipyridyl/*analogs & derivatives
Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Bioorg Med Chem Lett 2010 Jul 1;20(13):3868-71
neutral sphingomyelinase 3, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):681-90
sphingomyelin phosphodiesterase 1, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
J Obstet Gynaecol Res. 2009 Jun;35(3):421-8
neutral sphingomyelinase-
1, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
J Biol Chem 2000 Sep 8;275(36):28316-25
intestinal alkaline sphingomyelinase, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
Biochim Biophys Acta 2005 Feb 21;1687(1-3):94-102
intestinal alkaline sphingomyelinase, rat
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
Biochim Biophys Acta 2005 Feb 21;1687(1-3):94-102
SMPDL3B protein, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
Blood. 2006 Feb 1;107(3):1070-7
sphingomyelinase I, Loxosceles laeta
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase
*Spider Venoms.
Acta Crystallogr D Biol Crystallogr 2004 Jun;60(Pt 6):1112-4
SMPD3 protein, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
Smpd3 protein, mouse
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
SMPDL3A protein, human
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase
Tumor Markers, Biological.
J Urol 2002 Dec;168960:2645-9
TK4 sphingomyelinase
EC 3.1.4.-
*Sphingomyelin Phosphodiesterase
Hemolysin Proteins.
J Bacteriol 2002 Jan;184(2):540-6
scyphostatin
0
*Amides
*Pyrones
Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
J Antibiot (Tokyo) 1999 Jun;52(6):525-30
acid sphingomyelinase-
2
EC 3.1.4.-
*Sphingomyelin Phosphodiesterase.
J Biol Chem 1998 Jun 5;273(23):14374-9
acid sphingomyelinase-
1
EC 3.1.4.-
*Sphingomyelin Phosphodiesterase.
J Biol Chem 1998 Jun 5;273(23):14374-9
Smpd3 protein, rat
EC 3.1.4.12
*Sphingomyelin Phosphodiesterase.
J Biol Chem 1997 Jul 18;272(29):18082-6
altenusin
31186-12-6
*Biphenyl Compounds
Myosin-Light-Chain Kinase/antagonists & inhibitors
Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Biosci Biotech Biochem 1995 Jul;59(7):1333-5
fantofarone
114432-13-2 Benzeneethanamine, 3,4-
dimethoxy-
N-
methyl-
N-
(3-
(4-
((2-
(1-
methylethyl)-
1-
indolizinyl)sulfonyl)phenoxy)propyl)
*Indolizines
*Phenethylamines
Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Pharma Action
Calcium Channel Blockers
;
Enzyme Inhibitors
;
Vasodilator Agents
Naunyn Schmiedebergs Arch Pharmacol 1989;339(1-2):31
tricyclodecane-
9-
yl-
xanthogenate
83373-60-8
*Bridged Compounds
*Thiones
Type C Phospholipases/antagonists & inhibitors
Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
;
Antioxidants
;
Antiviral Agents
;
Phosphodiesterase Inhibitors
J Gen Virol 1985;66(Pt 9):1953
hlb protein, Staphylococcus aureus
EC 3.1.4.12
*Bacterial Toxins
*Hemolysin Proteins
*Sphingomyelin Phosphodiesterase.
Acta Pathol Microbiol Immunol Scand 1983;91(5):351; Infect Immun 1981;31(3):952