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Proto-Oncogenes

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Definition: Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.  "normal cellular genes homologous to viral oncogenes"   
Examples Genes, abl; Genes, bcl-1; Genes, bcl-2; Genes, erbA; Genes, erbB; Genes, fms; Genes, fos; Genes, jun; Genes, mos; Genes, myb; Genes, myc; Genes, ras; Genes, rel; Genes, sis; Genes, src 		Other names Proto Oncogenes; Proto Oncogene; Proto-Oncogene
 
SubstanceCAS Registry & nameCategoriesSource
Evi1 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogenes *Transcription Factors.
MECOM protein, human  0   *DNA-Binding Proteins *Proto-Oncogenes *Transcription Factors. Oncogene Res 1990;5(3):221

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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