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Genes, sis

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Definition: Retrovirus-associated DNA sequences (v-sis) originally isolated from the simian sarcoma virus (SSV). The proto-oncogene c-sis codes for a growth factor which is the B chain of PLATELET-DERIVED GROWTH FACTOR. v-sis or overexpression of c-sis causes tumorigenesis. The human sis gene is located at 22q12.3-13.1 on the long arm of chromosome 22.     
See Also Oncogene Proteins v-sis; Proto-Oncogene Proteins c-sis 		Other names v-sis Oncogene; v-sis Gene; v sis Oncogenes; v sis Genes; sis Oncogenes; sis Gene; c-sis Proto-Oncogene; c-sis Gene; c sis Proto Oncogenes; c sis Genes; Proto-Oncogenes, c-sis; Proto-Oncogene, c-sis; PDGFB Genes; PDGFB Gene; Oncogenes, v-sis; Oncogenes, sis; Oncogene, v-sis; Oncogene, sis; Genes, v-sis; Genes, c-sis

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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