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Poly I-C

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Definition: Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.  an interferon inducer; do not confuse with POLY I   
Pharmacological Action Antiviral Agents; Interferon Inducers 		Other names Polyribose Inosin Cytidil; Polyinosinic Polycytidylic Acid; Poly I C; Inosin-Cytidil, Polyribose; Polyribose Inosin-Cytidil; Polyinosinic-Polycytidylic Acid; Poly(rI).Poly(rC)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Retrogen D  0   *Poly I-C *Dextran Sulfate. AIDS 1989;3(12):858
poly(I,8-azidoI).poly(C12,U)  127815-79-6   *Azides *Poly I-C *Poly U. J Biol Chem 1990;265(10):5470
poly(I,8-azidoI).poly(C)  74721-51-0   *Azides *Poly I-C. J Biol Chem 1990;265(10):5470
ampligen  38640-92-5   *Poly I-C *Poly U RNA, Double-Stranded Base Pair Mismatch.
Pharma Action Antiviral Agents 		J Biol Response Mod 1985;4(5):495
poly I-5-mercapto-poly C  0   Poly I-C. Res Commun Chem Pathol Pharmacol 1984;45(3):407
poly IC-polylysine carboxymethyl dextran  97127-12-3 L-Lysine, 11,17,21-trihydroxy-, (+-)  *Dextrans Poly I-C Polylysine. J Interferon Res 1984;4(2):155
poly ICL  63779-59-9   Poly I-C Polylysine. J Urol 1984;131(1):139
poly(G,I).poly(C)  34607-23-3   *Poly G *Poly I-C. Antibiotiki 1982;27(11):827
poly(I):poly(C)-binding, 50 kDa protein, mouse  0   *Carrier Proteins Poly I-C. J Biochem (Tokyo) 1980;88(1):159
poly(2'-fluoro-2'-deoxyinosinic acid).polycytidylic acid  68777-96-8 5'-Inosinic acid, 2'-deoxy-2'-fluoro-, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1)  *Poly I-C. Eur J Biochem 1980;107(1):279
poly(2'-chloro-2'-deoxyinosinic acid).polycytidylic acid  70368-44-4 5'-Inosinic acid, 2'-chloro-2'-deoxy-, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1)  *Poly I-C. Eur J Biochem 1980;107(1):279
poly ICLC  59789-29-6   *Poly I-C Carboxymethylcellulose Sodium/*analogs & derivatives Polylysine/*analogs & derivatives.
Pharma Action Interferon Inducers 		Bull WHO 1979;57(5):807; J Infect Dis 139(3):267;1979; Lancet 2(7989):757;1976
poly(2'-azido-2'-deoxyinosinic acid).polycytidylic acid  65048-11-5 5'-Inosinic acid, 2'-azido-2'-deoxy-, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1)  *Deoxyribonucleotides *Poly I-C. Eur J Biochem 88(2):341;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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