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Phorbols

More information in Books or onNLM PubMed
Definition: The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).  carcinogens; D25-26 qualif   
Examples Phorbol Esters
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4alpha-phorbol 12,13-didecanone  0   *Phorbols. J Invest Dermatol 2007 Mar;127(3):654-9
lactucin  0   *Lactones *Phorbols *Sesquiterpenes. J Ethnopharmacol. 2006 Sep 19;107(2):254-8
pedilstatin  0   *Phorbols. J Nat Prod 2002 Sep;65(9):1262-5
13-O-myristyl-20-O-acetyl-12-deoxyphorbol  0   *Phorbols. Fitoterapia 2001 Mar;72(3):304-6
12-O-acetylphorbol-13-decanoate  20839-15-0   *Decanoates *Phorbols. Chem Pharm Bull (Tokyo) 1999 Sep;47(9):1346-7
phorbol 12-pyrenebutyrate 13-(3,3,3-trifloro-2-diazopropioate)  0   *Diazonium Compounds *Phorbols Isoenzymes Protein Kinase C. Bioorg Med Chem 1998 Jul;6(7):1117-26
pareirubrine A  147044-68-6 10H-Azuleno(1,2,3-ij)isoquinolin-10-one, 9-hydroxy-4,5,6,11-tetramethoxy  *Isoquinolines Phorbols Tropolone/*analogs & derivatives Alkaloids Plant Extracts. Chem Pharm Bull (Tokyo) 1993 Aug;41(8):1418-22
14-deoxylactucin  74635-52-2 Azuleno(4,5-b)furan-2,7-dione, 3,3a,4,5,9a,9b-hexahydro-4-hydroxy-6,9-dimethyl-3-methylene-, (3aR-(3aalpha,4alpha,9aalpha,9bbeta))  *Lactones *Phorbols *Sesquiterpenes. Planta Med 1991 Oct;57(5):444-6
xuelianlactone  107259-46-1 Azuleno(4,5-b)furan-2(3H)-one, decahydro-4-hydroxy-3-methyl-6,9-bis(methylene)-, (3R-(3alpha,3abeta,4alpha,6abeta,9abeta,9balpha))  *Phorbols *Sesquiterpenes Drugs, Chinese Herbal. Yao Hsueh Hsueh Pao 1986;21(9):680
phorbol  17673-25-5   *Phorbols. J Pharm Pharmacol 1981;33(11):737
paragracine  57695-32-6   *Phorbols *Imidazoles Cnidarian Venoms. Biophys J 1980;29(3):531
isohelenol  71013-32-6 Azuleno(6,5-b)furan-2,5-dione, 4,4a,7a,8,9,9a-hexahydro-4-hydroxy-3-(hydroxymethyl)-4a,8-dimethyl-, (4S-(4alpha,4abeta,7aalpha,8alpha,9aalpha))  *Phorbols *Sesquiterpenes. Lloydia 42(3):282;1979
isohelenalin  479-09-4 Azuleno(6,5-b)furan-2,5-dione, 4,4a,7a,8,9,9a-hexahydro-4-hydroxy-3,4a,8-trimethyl-, (4S-(4alpha,4abeta,7aalpha,8alpha,9aalpha))  *Phorbols *Sesquiterpenes. Lloydia 42(3):282;1979
tribromodamsin  67810-46-2 Azuleno(4,5-b)furan-2,9-dione, 3,3,7-tribromodecahydro  *Phorbols *Sesquiterpenes. Egypt J Bilharz 3(2):157;1976
solstitialin  22738-70-1 (3R-(3 alpha,3a alpha,6a alpha,8 beta,9a alpha,9b beta))-decahydro-3,8-dihydroxy-3-(hydroxymethyl)- 6,9-bis(methylene)azuleno(4,5-b)furan-2(3H)-one  *Phorbols *Sesquiterpenes Toxins, Biological. Acta Crystallogr B 26:554;1970

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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