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Nalidixic Acid

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Definition: A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.     
Pharmacological Action Anti-Infective Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors 		Other names Nalidixin; Sodium, Nalidixate; Acid, Nalidixic; Sodium Nalidixic Acid, Monohydrate; Sodium Nalidixic Acid, Anhydrous; Nevigramon; Nalidixate SodiumDrugs* : NEGGRAM; NALIDIXIC ACID
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PA 2789  0   *Piperazines Nalidixic Acid/*analogs & derivatives. J Med Chem 2004 Sep 9;47(19):4693-709
PA 2808  0   *Phosphoric Acid Esters Nalidixic Acid/*analogs & derivatives. J Med Chem 2004 Sep 9;47(19):4693-709
erythromycin nalidixate  0   Erythromycin/*analogs & derivatives Nalidixic Acid/*analogs & derivatives. Arzneimittelforschung 1995 Jul;45(7):813-4
citrated nalidixic acid  79449-95-9 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, mixt. with 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid  Nalidixic Acid/*analogs & derivatives. J Int Med Res 1981;9(1):58
7-carboxynalidixic acid  1088-16-0 1,8-Naphthyridine-2,6-dicarboxylic acid, 8-ethyl-5,8-dihydro-5-oxo  Nalidixic Acid/*analogs & derivatives. J Chromatogr 1980;181(3-4):399
7-hydroxynalidixic acid  3759-18-0 1-ethyl-1,4-dihydro-7-(hydroxymethyl)-4-oxo-1,8-naphthyrid ine-3-carboxylic acid  Nalidixic Acid/*analogs & derivatives. Acta Microbiol 22(4):433;1975
1-methyl-7-(2-(5-nitro-2-furyl)vinyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate  24235-63-0   Nalidixic Acid/*analogs & derivatives. Gan 65(1):1;1974; Gan 66(3):259;1975
nalidixic acid, phenazopyridine drug combination  0   *Azo Compounds *Nalidixic Acid Drug Combinations. Prensa Med Mex 37(5):228;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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