encyclopedia of medical concepts
ψ
IMP Dehydrogenase
More information
in Books
or on
Definition
: An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
Other names
Inosinic Acid Dehydrogenase; Inosine 5 Monophosphate Dehydrogenase; Dehydrogenase, Inosinic Acid; Dehydrogenase, Inosine-
5-
Monophosphate; Dehydrogenase, IMP; Acid Dehydrogenase, Inosinic; Inosine-
5-
Monophosphate Dehydrogenase
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
((4-
fluorophenyl)(1-
methyl-
1H-
imidazol-
2-
yl)methyl)-
2-
methyl-
3-
(1,2,4-
thiadiazol-
5-
yl)-
1H-
indole-
6-
carboxamide
0
*Indoles
*Thiadiazoles
IMP Dehydrogenase/antagonists & inhibitors.
Eur J Pharmacol. 2012 Jan 5;674(1):58-63.
F01 1358B
0
Mycophenolic Acid/*analogs & derivatives
IMP Dehydrogenase/antagonists & inhibitors.
J Antibiot (Tokyo) 2009 Sep;62(9):527-9
F01 1358A
0
Mycophenolic Acid/*analogs & derivatives
IMP Dehydrogenase/antagonists & inhibitors.
J Antibiot (Tokyo) 2009 Sep;62(9):527-9
AVN 944
0
*Carbamates
*Phenylurea Compounds
IMP Dehydrogenase/antagonists & inhibitors.
Leuk Res 2008 Jan;32(1):131-41
P(1)-
(7-
hydroxy-
6-
(hydroxyethyl)-
5-
methoxy-
4-
methylphthalan-
1-
one-
2-
yl)-
P(2)-
(2-
ethyladenosin-
5'-
yl)methylenebis(phosphonate)
0
*Diphosphonates
Adenosine Monophosphate/*analogs & derivatives
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 2007 Nov 15;50(23):5743-51
N-
(2-
(6-
(4-
ethylpiperazin-
1-
yl)pyridin-
3-
yl)propan-
2-
yl)-
2-
fluoro-
9-
oxo-
9,10-
dihydroacridine-
3-
carboxamide
0
*Acridines
*Piperazines
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 2007 Jul 26;50(15):3730-42
P(1)-
(7-
hydroxy-
6-
(ethyl-
2-
yl)-
5-
methoxy-
4-
methylphthalan-
1-
one)methylenephospho-
P(2)-
(adenosin-
5'-
yl)phosphonate
0
Adenosine Monophosphate/*analogs & derivatives
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 2006 Aug 10;49(16):5018-22
P(1)-
(adenosin-
5'-
yl)methylenephospho-
P(2)-
(7-
hydroxy-
6-
(ethyl-
2-
yl)-
5-
methoxy-
4-
methylphthalan-
1-
one)phosphonate
0
Adenosine Monophosphate/*analogs & derivatives
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 2006 Aug 10;49(16):5018-22
VX-
944
0
*Organic Chemicals
IMP Dehydrogenase/antagonists & inhibitors.
Oncogene 2005 Sep 1;24(38):5888-96
IMPDH2 protein, human
EC 1.1.1.205
*IMP Dehydrogenase.
Transplant Proc 2004 Nov;36(9):2787-90
IMPDH2, mouse
EC 1.1.1.205
*IMP Dehydrogenase.
Adv Exp Med Biol 2003;533():13-8
IMPDH1 protein, human
EC 1.1.1.205
*IMP Dehydrogenase.
Adv Exp Med Biol 2003;533():1-11
2-
(2-
fluorovinyl)inosine 5'-
monophosphate
0
Inosine Monophosphate/*analogs & derivatives
IMP Dehydrogenase/antagonists & inhibitors.
Bioorg Med Chem Lett 2003 Feb 24;13(4):645-7
IMD2 protein, S cerevisiae
EC 1.1.1.205
*IMP Dehydrogenase
*Saccharomyces cerevisiae Proteins.
Mol Cell Biol 2003 Sep;23(17):6267-78
IMPDH1, mouse
EC 1.1.1.205
*IMP Dehydrogenase.
Hum Mol Genet 2002 Mar 1;11(5)
N-
(2-
(2-
((3-
methoxy-
4-
(5-
oxazolyl)phenyl)amino)-
5-
oxazolyl)phenyl)-
N-
methyl-
4-
morpholineacetamide
0
*Morpholines
*Oxazoles
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 2002 May 23;45(11):2127-30
1,5-
diazabicyclo(3.1.0)hexane-
2,4-
dione
0
*Bicyclo Compounds, Heterocyclic
IMP Dehydrogenase/antagonists & inhibitors.
Biochemistry. 2000 Nov 14;39(45):13641-50
N-
3-
(3-
(3-
methoxy-
4-
oxazol-
5-
ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-
3-
yl ester
0
*Carbamates
*Phenylurea Compounds
IMP Dehydrogenase/antagonists & inhibitors.
Antimicrob Agents Chemother 2000 Apr;44(4):859-66
selenophenfurin
0
*Ribonucleosides
*Organoselenium Compounds
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 1997 May 23;40(11):1731-7
benzamide adenine nucleotide
156724-91-3
*Adenine Nucleotides
*Benzamides
IMP Dehydrogenase/antagonists & inhibitors.
J Med Chem 1996 Jun 7;39(12):2422-6
5-
ethynyl-
1-
(5-
O-
phosphonoribofuranosyl)imidazole-
4-
carboxamide
126004-36-2
*Ribonucleotides
IMP Dehydrogenase/antagonists & inhibitors.
Biochemistry 1996 Jan 9;35(1):95-101
isorawsonol
0
*Benzhydryl Compounds
*Hydrocarbons, Brominated
IMP Dehydrogenase/antagonists & inhibitors.
J Nat Prod 1994 Jul;57(7):947-52
3-
(1-
deoxyribofuranosyl)benzamide
138385-29-2
*Nucleosides
IMP Dehydrogenase/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
Biochem Biophys Res Commun 1992 Aug 14;186(3):1600-06
mycophenolate mofetil
128794-94-5
Mycophenolic Acid/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents
Dermatologic Agents
Enzyme Inhibitors
IMP Dehydrogenase/antagonists & inhibitors
Prodrugs.
Pharma Action
Immunosuppressive Agents
JAMA 1990;263(9):1184
CELLCEPT
;
MYCOPHENOLATE MOFETIL
;
MYCOPHENOLATE MOFETIL HYDROCHLORIDE
thiazole-
4-
carboxamide adenine dinucleotide
83285-83-0
*Adenine Nucleotides
IMP Dehydrogenase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
J Med Chem 1983;26(6):922
4-
carbamoylimidazolium 5-
olate
56973-26-3
*Imidazoles
IMP Dehydrogenase/antagonists & inhibitors.
Cancer Res 1982;42(3):1098
bredinin
50924-49-7
*Ribonucleosides
IMP Dehydrogenase/antagonists & inhibitors.
Pharma Action
Anti-Inflammatory Agents, Non-Steroidal
;
Anti-Bacterial Agents
;
Antibiotics, Antineoplastic
;
Antimalarials
;
Enzyme Inhibitors
;
Immunosuppressive Agents
Cancer Res 35(7):1643;1975; Experientia 33(4):502;1977; J Antibiotics 27(10):775;1974; J Antibiotics 29(12):1320;1976