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Cephalosporins
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Definition
: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Pharmacological Action
Anti-Bacterial Agents
Examples
Cefamandole
;
Cefazolin
;
Cefonicid
;
Cefsulodin
;
Cephacetrile
;
Cephalexin
;
Cephaloridine
;
Cephamycins
Other names
Antibiotics, Cephalosporin; Cephalosporin Antibiotics; Acids, Cephalosporanic; Cephalosporanic Acids
Substance
CAS Registry & name
Categories
Source
Drugs
*
7-
amino-
3-
thiomethyl-
3-
cephalosporanic acid
0
*Cephalosporins.
Allergy. 2009 Sep;64(9):1390-1
TD 1792
0
*Cephalosporins
*Glycopeptides.
J Antibiot (Tokyo) 2008 Oct;61(10):603-14
FR 295389
0
*Cephalosporins.
J Antibiot (Tokyo) 2008 Jan;61(1):36-9
KKJ 00016
0
*Cephalosporins.
Exp Mol Med 2007 Jun 30;39(3):335-42
FR 264205
0
*Cephalosporins.
Antimicrob Agents Chemother 2007 Mar;51(3):826-30
cefovecin
0
*Cephalosporins.
Antimicrob Agents Chemother 2006 Jul;50(7):2286-92
PPI-
0903
0
*Cephalosporins
Staphylococcal Infections
Methicillin Resistance.
TEFLARO
glutaryl C-
Mel
0
*Cephalosporins
*Nitrogen Mustard Compounds.
Bioconjug Chem 2006 Mar-Apr;17(2):410-8
ID-
7181
0
*Cephalosporins.
Arzneimittelforschung. 2005;55(9):549-56
ceftobiprole medocaril
0
*Cephalosporins.
Antimicrob Agents Chemother 2005 Sep;49(9):3789-93
T 91825
0
*Cephalosporins.
J Infect Chemother 2004 Jun;10(3):146-56
CB 181963
0
*Cephalosporins.
Antimicrob Agents Chemother 2004 Jul;48(7):2719-23
HMRZ 86
0
*Cephalosporins.
J Antimicrob Chemother 2004 May;53(5):888-9
7-
(1-
pentafluorophenoxyacetamido)-
3-
(2-
(5-
methyl-
1,3,4-
thiodiazolyl)thiomethyl)-
delta(3)-
cephem-
4-
carboxylic acid
0
*Cephalosporins.
AAPS PharmSciTech 2001;2(4):23
NB 2030
0
*Cephalosporins
*Tetrazoles.
Antimicrob Agents Chemother 2004 Feb;48(2):477-83
LB 11058
0
*Cephalosporins.
Antimicrob Agents Chemother. 2004 Jan;48(1):53-62
1-
dethia-
3-
aza-
1-
carba-
2-
oxacephem
0
*Cephalosporins.
Org Biomol Chem 2003 Jul 21;1(14):2461-7
KR-
999002
0
*Cephalosporins.
Arch Pharm Res. 2003 Jan;26(1):83-8
KR-
999001
0
*Cephalosporins.
Arch Pharm Res. 2003 Jan;26(1):83-8
KR-
984055
0
*Cephalosporins.
Arch Pharm Res. 2003 Jan;26(1):83-8
7-
(2-
(5-
amino-
1,2,4-
thiadiazol-
3-
yl)-
2-
ethoxyiminoacetamido)-
3-
(1-
(3-
methylaminopropyl)-
1H-
imidazo(4,5-
b)pyridinium-
4-
yl)methyl-
3-
cephem-
4-
carboxylate
0
*Cephalosporins.
J Antibiot (Tokyo) 2002 Nov;55(11):975-92
NB 2001
0
*Cephalosporins
Triclosan/*analogs & derivatives.
Antimicrob Agents Chemother 2002 May;46(5):1262-8
7-
bromoacetyl aminocephalosporanic acid
0
*Cephalosporins
Penicillin Amidase/antagonists & inhibitors.
J Biol Chem 2002 Mar 22;277(12):10256-64
7-
tert-
butoxycarbonylamino-
2-
ketocarbacepham
0
*Cephalosporins.
J Org Chem 2002 Jan 25;67(2):598-601
ceftobiprole
0
*Cephalosporins.
Antimicrob Agents Chemother 2002 Jan;46(1):171-7
SC004
0
*Cephalosporins.
Chemotherapy 2001 May-Jun;47(3):157-69
SC002
0
*Cephalosporins.
Chemotherapy 2001 May-Jun;47(3):157-69
A 27223
0
*Cephalosporins.
Bioorg Med Chem Lett 2001 Mar 26;11(6):797-801
cefcapene pivoxil hydrochloride
0
*Cephalosporins.
Contact Dermatitis 2001 Mar;44(3):197
Ro 63-
9141
0
*Cephalosporins.
Antimicrob Agents Chemother 2001 Mar;45(3):825-36
adipoyl-
7-
amino-
3-
deacetoxycephalosporanic acid
0
*Cephalosporins.
J Chromatogr A. 2001 Jan 26;908(1-2):273-91
CP 6679
0
*Cephalosporins.
Bioorg Med Chem 2000 Dec;8(12):2781-9
RWJ 54428
0
*Cephalosporins.
J Antibiot (Tokyo). 2000 Nov;53(11):1272-81
cefmatilen
0
*Cephalosporins.
J Chromatogr B Biomed Sci Appl 2000 Nov 10;749(1):101-10
LB 10827
0
*Cephalosporins.
Antimicrob Agents Chemother. 2000 Dec;44(12):3272-7
FR 192752
0
*Cephalosporins.
J Antibiot (Tokyo) 2000 Oct;53(10):1223-7
7-
(2-
(5-
amino-
1,2,4-
thiadiazol-
-
3-
yl)-
2-
cyclopentyloxyiminoacetamido)-
3-
(3,6-
diaminoimidazo(1,2-
b)pyridazinium-
1-
yl)methyl-
3-
cephem-
4-
carboxylate
0
*Cephalosporins.
J Antibiot (Tokyo) 2000 Oct;53(10):1071-85
7 beta-
(2-
carboxy-
2-
(4-
hydroxyphenyl)acetamido)-
7 alpha-
methoxy-
3-
(((1-
methyl-
1H-
tetrazol-
5-
yl)thio)methyl)-
1-
oxa-
1-
dethia-
3-
cephem-
4-
carboxylic acid
79120-38-0 5-
Oxa-
1-
azabicyclo(4.2.0)oct-
2-
ene-
2-
carboxylic acid, 7-
((carboxy(4-
hydroxyphenyl)acetyl)amino)-
7-
methoxy-
3-
(((1-
methyl-
-
1H-
tetrazol-
5-
yl)thio)methyl)-
8-
oxo-
, (6R-
(6alpha,7alpha,7(S*)))
*Cephalosporins.
J Pharm Sci 1981 Jan;70(1):112-3
SYN 1390
0
*Cephalosporins
Leukocyte Elastase/antagonists & inhibitors.
Steroids 2000 Apr;65(4):697-703
SYN 1396
0
*Cephalosporins
Leukocyte Elastase/antagonists & inhibitors.
Steroids 2000 Apr;65(4):697-703
3-
(2-
(2-
aminothiazol-
4-
yl)-
2-
((((5-
cyano-
3,4-
dihydroxythiophen-
2-
yl)carboxymethyl)oxy)imino)acetamido)-
7-
(3-
(1-
quinolinium)-
1-
propenyl)-
5-
thia-
1-
azabicyclo(4.2.0)octane-
2-
carboxylic acid
0
*Cephalosporins.
Bioorg Med Chem Lett 2000 Feb 21;10(4):349-52
FR 86521
0
*Cephalosporins.
J Antibiot (Tokyo) 1999 Dec;52(12):1152-5
deacetoxycephalosporin G
0
*Cephalosporins
Penicillin G.
Appl Biochem Biotechnol 1999 Sep;145-52
7-
(2-
(N(b)-
2-
nitrobenzyloxycarbonyl)hydrazino-
3-
phenylpropanamido)cephalosporanic acid
0
*Carbamates
*Cephalosporins.
J Med Chem 2000 Jan 13;43(1):27-40
7-
((2-
aminothiazol-
4-
yl)-
2-
-
(N-
hydroxyimino)acetamido)-
3-
((3-
chloroisoxazol-
5-
yl)ethenyl)cyclosporanic acid
0
*Cephalosporins.
J Antibiot (Tokyo) 1998 Dec;51(12):1122-5
7-
((2-
aminothiazol-
4-
yl)-
2-
(N-
hydroxyimino)acetamido)-
3-
((3-
methoxyisoxazol-
5-
yl)ethenyl)cephalosporanic acid
0
*Cephalosporins.
J Antibiot (Tokyo) 1998 Dec;51(12):1122-5
3-
((3-
(1-
acetoxyethyl)isoxazol-
5-
yl)ethenyl)-
7-
((2-
aminothiazol-
4-
yl)-
2-
(methoxyimino)acetamido)cephalosporanic acid
0
*Cephalosporins.
J Antibiot (Tokyo) 1998 Dec;51(12):1117-21
Ro 48-
8724
0
*Cephalosporins
beta-Lactamases/antagonists & inhibitors.
Diagn Microbiol Infect dis 1998 Oct;32(2):85-94
Ro 48-
5545
0
*Cephalosporins
beta-Lactamases/antagonists & inhibitors.
Diagn Microbiol Infect Dis 1998 Oct;32(2):85-94
Ro 48-