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Cephalosporins

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Definition: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.     
Pharmacological Action Anti-Bacterial Agents
Examples Cefamandole; Cefazolin; Cefonicid; Cefsulodin; Cephacetrile; Cephalexin; Cephaloridine; Cephamycins 		Other names Antibiotics, Cephalosporin; Cephalosporin Antibiotics; Acids, Cephalosporanic; Cephalosporanic Acids
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-amino-3-thiomethyl-3-cephalosporanic acid  0   *Cephalosporins. Allergy. 2009 Sep;64(9):1390-1
TD 1792  0   *Cephalosporins *Glycopeptides. J Antibiot (Tokyo) 2008 Oct;61(10):603-14
FR 295389  0   *Cephalosporins. J Antibiot (Tokyo) 2008 Jan;61(1):36-9
KKJ 00016  0   *Cephalosporins. Exp Mol Med 2007 Jun 30;39(3):335-42
FR 264205  0   *Cephalosporins. Antimicrob Agents Chemother 2007 Mar;51(3):826-30
cefovecin  0   *Cephalosporins. Antimicrob Agents Chemother 2006 Jul;50(7):2286-92
PPI-0903  0   *Cephalosporins Staphylococcal Infections Methicillin Resistance. TEFLARO
glutaryl C-Mel  0   *Cephalosporins *Nitrogen Mustard Compounds. Bioconjug Chem 2006 Mar-Apr;17(2):410-8
ID-7181  0   *Cephalosporins. Arzneimittelforschung. 2005;55(9):549-56
ceftobiprole medocaril  0   *Cephalosporins. Antimicrob Agents Chemother 2005 Sep;49(9):3789-93
T 91825  0   *Cephalosporins. J Infect Chemother 2004 Jun;10(3):146-56
CB 181963  0   *Cephalosporins. Antimicrob Agents Chemother 2004 Jul;48(7):2719-23
HMRZ 86  0   *Cephalosporins. J Antimicrob Chemother 2004 May;53(5):888-9
7-(1-pentafluorophenoxyacetamido)-3-(2-(5-methyl-1,3,4-thiodiazolyl)thiomethyl)-delta(3)-cephem-4-carboxylic acid  0   *Cephalosporins. AAPS PharmSciTech 2001;2(4):23
NB 2030  0   *Cephalosporins *Tetrazoles. Antimicrob Agents Chemother 2004 Feb;48(2):477-83
LB 11058  0   *Cephalosporins. Antimicrob Agents Chemother. 2004 Jan;48(1):53-62
1-dethia-3-aza-1-carba-2-oxacephem  0   *Cephalosporins. Org Biomol Chem 2003 Jul 21;1(14):2461-7
KR-999002  0   *Cephalosporins. Arch Pharm Res. 2003 Jan;26(1):83-8
KR-999001  0   *Cephalosporins. Arch Pharm Res. 2003 Jan;26(1):83-8
KR-984055  0   *Cephalosporins. Arch Pharm Res. 2003 Jan;26(1):83-8
7-(2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido)-3-(1-(3-methylaminopropyl)-1H-imidazo(4,5-b)pyridinium-4-yl)methyl-3-cephem-4-carboxylate  0   *Cephalosporins. J Antibiot (Tokyo) 2002 Nov;55(11):975-92
NB 2001  0   *Cephalosporins Triclosan/*analogs & derivatives. Antimicrob Agents Chemother 2002 May;46(5):1262-8
7-bromoacetyl aminocephalosporanic acid  0   *Cephalosporins Penicillin Amidase/antagonists & inhibitors. J Biol Chem 2002 Mar 22;277(12):10256-64
7-tert-butoxycarbonylamino-2-ketocarbacepham  0   *Cephalosporins. J Org Chem 2002 Jan 25;67(2):598-601
ceftobiprole  0   *Cephalosporins. Antimicrob Agents Chemother 2002 Jan;46(1):171-7
SC004  0   *Cephalosporins. Chemotherapy 2001 May-Jun;47(3):157-69
SC002  0   *Cephalosporins. Chemotherapy 2001 May-Jun;47(3):157-69
A 27223  0   *Cephalosporins. Bioorg Med Chem Lett 2001 Mar 26;11(6):797-801
cefcapene pivoxil hydrochloride  0   *Cephalosporins. Contact Dermatitis 2001 Mar;44(3):197
Ro 63-9141  0   *Cephalosporins. Antimicrob Agents Chemother 2001 Mar;45(3):825-36
adipoyl-7-amino-3-deacetoxycephalosporanic acid  0   *Cephalosporins. J Chromatogr A. 2001 Jan 26;908(1-2):273-91
CP 6679  0   *Cephalosporins. Bioorg Med Chem 2000 Dec;8(12):2781-9
RWJ 54428  0   *Cephalosporins. J Antibiot (Tokyo). 2000 Nov;53(11):1272-81
cefmatilen  0   *Cephalosporins. J Chromatogr B Biomed Sci Appl 2000 Nov 10;749(1):101-10
LB 10827  0   *Cephalosporins. Antimicrob Agents Chemother. 2000 Dec;44(12):3272-7
FR 192752  0   *Cephalosporins. J Antibiot (Tokyo) 2000 Oct;53(10):1223-7
7-(2-(5-amino-1,2,4-thiadiazol--3-yl)-2-cyclopentyloxyiminoacetamido)-3-(3,6-diaminoimidazo(1,2-b)pyridazinium-1-yl)methyl-3-cephem-4-carboxylate  0   *Cephalosporins. J Antibiot (Tokyo) 2000 Oct;53(10):1071-85
7 beta-(2-carboxy-2-(4-hydroxyphenyl)acetamido)-7 alpha-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-1-oxa-1-dethia-3-cephem-4-carboxylic acid  79120-38-0 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-3-(((1-methyl- -1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha,7(S*)))  *Cephalosporins. J Pharm Sci 1981 Jan;70(1):112-3
SYN 1390  0   *Cephalosporins Leukocyte Elastase/antagonists & inhibitors. Steroids 2000 Apr;65(4):697-703
SYN 1396  0   *Cephalosporins Leukocyte Elastase/antagonists & inhibitors. Steroids 2000 Apr;65(4):697-703
3-(2-(2-aminothiazol-4-yl)-2-((((5-cyano-3,4-dihydroxythiophen-2-yl)carboxymethyl)oxy)imino)acetamido)-7-(3-(1-quinolinium)-1-propenyl)-5-thia-1-azabicyclo(4.2.0)octane-2-carboxylic acid  0   *Cephalosporins. Bioorg Med Chem Lett 2000 Feb 21;10(4):349-52
FR 86521  0   *Cephalosporins. J Antibiot (Tokyo) 1999 Dec;52(12):1152-5
deacetoxycephalosporin G  0   *Cephalosporins Penicillin G. Appl Biochem Biotechnol 1999 Sep;145-52
7-(2-(N(b)-2-nitrobenzyloxycarbonyl)hydrazino-3-phenylpropanamido)cephalosporanic acid  0   *Carbamates *Cephalosporins. J Med Chem 2000 Jan 13;43(1):27-40
7-((2-aminothiazol-4-yl)-2--(N-hydroxyimino)acetamido)-3-((3-chloroisoxazol-5-yl)ethenyl)cyclosporanic acid  0   *Cephalosporins. J Antibiot (Tokyo) 1998 Dec;51(12):1122-5
7-((2-aminothiazol-4-yl)-2-(N-hydroxyimino)acetamido)-3-((3-methoxyisoxazol-5-yl)ethenyl)cephalosporanic acid  0   *Cephalosporins. J Antibiot (Tokyo) 1998 Dec;51(12):1122-5
3-((3-(1-acetoxyethyl)isoxazol-5-yl)ethenyl)-7-((2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)cephalosporanic acid  0   *Cephalosporins. J Antibiot (Tokyo) 1998 Dec;51(12):1117-21
Ro 48-8724  0   *Cephalosporins beta-Lactamases/antagonists & inhibitors. Diagn Microbiol Infect dis 1998 Oct;32(2):85-94
Ro 48-5545  0   *Cephalosporins beta-Lactamases/antagonists & inhibitors. Diagn Microbiol Infect Dis 1998 Oct;32(2):85-94
Ro 48-8391  0   *Cephalosporins. Diagn Microbiol Infect Dis 1998 Oct;32(2):85-94
CP 0467  0   *Cephalosporins *Thiazoles. Bioorg Med Chem 1998 Jul;6(7):1009-17
E 1101  0   *Cephalosporins. Chemotherapy 1998 Sep-Oct;44(5):328-30
FK 041  0   *Cephalosporins. J Antibiot (Tokyo) 1998 Jul;51(7):683-7
Ro 25-6833  0   *Cephalosporins *Thiazoles. J Pharm Sci 1998 Apr;87(4):496-500
C-Mel  0   *Cephalosporins Melphalan/*analogs & derivatives. Biochem Conj 1998 Mar-Apr;9(2):255-9
RU 59863  0   *Cephalosporins. Diagn Microbiol Infect Dis 1997 Jun;28(2):93-100
7-(2-(2-aminothiazol-4-yl)-2-(((1,5-dihydroxy-4-pyridon-2-yl)methoxy)imino)acetamido)-3-((((4-methyl-5-carboxymethyl)thiazol-2-yl)thio)methyl)-8-oxo-1-aza-4-thiabicyclo(4.2.0)oct-ene-2-carboxylic acid  0   *Cephalosporins. Bioorg Med Chem 1996 Dec;4(12):2135-49
TOC 50  0   *Cephalosporins. Chemotherapy 1996 Jul-Aug;42(4):253-8
LB 10522  0   *Cephalosporins. Antimicrob Agents Chemother 1996 Aug;40(8):1825-31
LB 10517  0   *Cephalosporins. J Antimicrob Chemother 1996 Apr;37(4):711-26
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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