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Leukocyte Elastase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.      Other names Leukocyte Elastase, Polymorphonuclear; Elastase, Polymorphonuclear Leukocyte; Elastase, PMN; Elastase, Neutrophil; Elastase, Lysosomal; Elastase, Leukocyte; Elastase, Granulocyte; Granulocyte Elastase; Polymorphonuclear Leukocyte Elastase; PMN Elastase; Neutrophil Elastase; Lysosomal Elastase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
KRP-109  0   *Pyrrolidines *Benzoxazines Leukocyte Elastase/antagonists & inhibitors. Pulm Pharmacol Ther. 2011 Dec;24(6):660-5.
cereoaldomine  0   *Polyketides Leukocyte Elastase/antagonists & inhibitors. J Nat Prod. 2011 Oct 28;74(10):2282-5
trypethelone  0   *Polyketides Leukocyte Elastase/antagonists & inhibitors. J Nat Prod. 2011 Oct 28;74(10):2282-5
cereolactam  0   *Polyketides Leukocyte Elastase/antagonists & inhibitors. J Nat Prod. 2011 Oct 28;74(10):2282-5
pterolinus L  0   *Chalcones Leukocyte Elastase/antagonists & inhibitors. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5630-2.
pterolinus K  0   *Phenanthrenes Leukocyte Elastase/antagonists & inhibitors. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5630-2.
N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide  0   *Pyridones *Sulfones Leukocyte Elastase/antagonists & inhibitors. J Pharmacol Exp Ther. 2011 Oct;339(1):313-20.
6-O-p-methoxycinnamoyl scandoside methyl ester  0   *Iridoids Leukocyte Elastase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Jan 15;20(2):512-5
isodeoxyhelicobasidin  0   *Cyclopentanes *Benzoquinones Leukocyte Elastase/antagonists & inhibitors. J Antibiot (Tokyo) 2009 Jun;62(6):333-4
Iris protein, Ixodes ricinus  0   *Serpins Leukocyte Elastase/antagonists & inhibitors. J Biol Chem 2006 Sep 8;281(36):26361-9
depelestat  0   *Peptides Leukocyte Elastase/antagonists & inhibitors. J Pharmacol Exp Ther 2006 Aug;318(2):803-9
ONO 6818  0   *Oxadiazoles Pyrimidinones Leukocyte Elastase/antagonists & inhibitors. J Med Chem 2000 Dec 28;43(26):4927-9
SYN 1390  0   *Cephalosporins Leukocyte Elastase/antagonists & inhibitors. Steroids 2000 Apr;65(4):697-703
SYN 1396  0   *Cephalosporins Leukocyte Elastase/antagonists & inhibitors. Steroids 2000 Apr;65(4):697-703
2-(6'-methoxy-3',4'-dihydro-1'-naphthyl)-4H-3,1-benzoxazin-4-one  0   *Benzoxazines Leukocyte Elastase. Bioorg Med Chem Lett 1999 May 3;9(9):1291-4
FR 901277  0   *Amides Leukocyte Elastase. Inflamm Res 1999 Mar;48(3):160-7
GW 311616  0   *Piperidines Leukocyte Elastase/antagonists & inhibitors. Rapid Commun Mass Spectrom 1999;13(5):456-63
2-(3-methylsulfonylamino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide  0   *Pyridones *Sulfonamides Leukocyte Elastase/antagonists & inhibitors. Naunyn Schmiedebergs Arch Pharmacol 1998 Aug;358(2):253-63
NX 21909  0   *Oligonucleotides Valine/*analogs & derivatives Leukocyte Elastase/antagonists & inhibitors. Curr Biol 1997 Nov 1;7(11):877-80
FK 706  0   *Benzoates *Pyrrolidines Pancreatic Elastase/antagonists & inhibitors Leukocyte Elastase/antagonists & inhibitors. Eur J Pharmacol 1997 Oct 15;337(1):63-71
ZD 8321  0   *Oligopeptides Leukocyte Elastase/antagonists & inhibitors. J Med Chem 1997 Sep 26;40(20):3173-81
4-((((4-chloro-3-(((((4-hydroxy-3,5-di-tert-butylphenyl)thio)acetyl)amino)sulfonyl)phenyl)carbonyl)amino)sulfonyl)benzoyl-valyl-(perhydroindole-2-carbonyl)-valine trifluoromethyl ketone  0   *Oligopeptides Leukocyte Elastase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1906-18
((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide  105080-60-2   *Dipeptides Leukocyte Elastase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1876-85
4-chloro-7-(iodoacetyl)amino-3-methoxyisocoumarin  0   *Coumarins Leukocyte Elastase/antagonists & inhibitors. Acta Crystallogr C 1996 Feb 15;52 Pt 2:451-3
ONO 5046  127373-66-4 Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)  *Sulfonamides Glycine/*analogs & derivatives Stereoisomerism Leukocyte Elastase/antagonists & inhibitors.
Pharma Action Serine Proteinase Inhibitors 		Biochem Biophys Res Commun 1991;177(2):814
flurithromycin  82664-20-8   Erythromycin/analogs & derivatives Leukocyte Elastase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Chemioterapia 1985;4(2):156
alpha 1-antitrypsin-leukocyte elastase complex  0   *alpha 1-Antitrypsin *Leukocyte Elastase. Blood 1983;61(5):842

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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