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Aldehyde Dehydrogenase
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Definition
: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
Examples
omega-Crystallins
Other names
D-
Glucuronolactone Dehydrogenase; Dehydrogenase, D-
Glucuronolactone; Dehydrogenase, Aldehyde; D Glucuronolactone Dehydrogenase; Aldehyde NAD Oxidoreductase; Aldehyde-
NAD Oxidoreductase; Aldehyde Dehydrogenase E2; Aldehyde Dehydrogenase E1; Aldehyde Dehydrogenase (NAD(+))
Substance
CAS Registry & name
Categories
Source
Drugs
*
ALDH3-
1 protein, soybean
EC 1.1.1.70
*Soybean Proteins
*Aldehyde Dehydrogenase.
Yi Chuan. 2010 May;32(5); 492-7
ALDH16A1 protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Neurogenetics. 2009 Jul;10(3):217-28
ALDH1L1 protein, human
EC 1.5.1.6
*Aldehyde Dehydrogenase.
J Neuropathol Exp Neurol 2008 Dec;67(12):1194-204
ALDH1B1 protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Stem Cells 2007 Oct;25(10):2628-37
ALDH7B4 protein, Arabidopsis
EC 1.2.1.3
*Aldehyde Dehydrogenase
*Arabidopsis Proteins.
Plant Mol Biol 2005 Feb;57(3):315-32
ALDH3I1 protein, Arabidopsis
EC 1.2.1.3
*Aldehyde Dehydrogenase
*Arabidopsis Proteins.
Plant Mol Biol 2005 Feb;57(3):315-32
aldehyde dehydrogenase 2, mouse
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Alcohol Clin Exp Res 2006 Oct;30(10):1659-69
aldehyde dehydrogenase 1A1, mouse
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Alcohol Clin Exp Res 2006 Oct;30(10):1659-69
gamma-
trimethylaminobutyraldehyde dehydrogenase, mouse
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Anal Biochem. 2006 Jul 1;354(1):132-9
Aldh1a2 protein, mouse
EC 1.14.13.-
*Aldehyde Dehydrogenase.
J Cell Biol 2006 Jul 3;174(1):101-13
ALDH1A1 protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Acta Pol Pharm 2005 Nov-Dec;62(6):427-33
nicotinoprotein aldehyde dehydrogenase, Sphingomonas macrogoltabidus
EC 1.2.1.-
*Aldehyde Dehydrogenase.
Appl Microbiol Biotechnol 2005 Sep;68(5):639-46
Aldh2 protein, rat
EC 1.2.1.3
*Aldehyde Dehydrogenase
*Mitochondrial Proteins.
Pharmacogenetics 2003 Aug;13(8):509-15
AASDH protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase
*Neoplasm Proteins.
Mol Biol Rep. 2005 Mar;32(1):47-53
aspartyl semialdehyde dehydrogenase, Helicobacter pylori
EC 1.2.1.3
*Aldehyde Dehydrogenase
*Bacterial Proteins.
J Nat Prod 2005 May;68(5):804-6
8S benzo(a)pyrene-
binding protein, mouse
0
*Aldehyde Dehydrogenase
*Carrier Proteins.
4S benzo(a)pyrene-
binding protein, rat
EC 1.2.1.-
*Aldehyde Dehydrogenase
*Carrier Proteins.
reduced epidermal fluorescence1 protein, Arabidopsis
EC 1.2.1.3.
*Aldehyde Dehydrogenase.
Plant Cell 2004 Feb;16(2);544-54
Aldh7a1 protein, mouse
EC 1.2.1.3
*Aldehyde Dehydrogenase.
DNR-
BP54 protein, mouse
EC 1.2.1.-
*Aldehyde Dehydrogenase.
ALDH3A1 protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase
Eye Proteins.
Biochem J 2003 Dec 15;376(Pt 3):615-23
zRalDH protein, Taeniopygia guttata
EC 1.2.1.-
*Aldehyde Dehydrogenase
*Nerve Tissue Proteins.
Neuron. 2000 Aug;27(2)
N-
(ethoxycarbonyl)-
O-
(diethylcarbamoyl)benzenesulfohydroxamic acid
0
*Hydroxamic Acids
*Sulfonamides
Aldehyde Dehydrogenase/antagonists & inhibitors.
J Med Chem 1999 Oct 7;42(20):4016-20
N-
(N,N-
diethylcarbamoyl)-
O-
methylbenzenesulfohydroxamic acid
0
*Hydroxamic Acids
*Sulfonamides
Aldehyde Dehydrogenase/antagonists & inhibitors.
J Med Chem 1999 Oct 7;42(20):4016-20
resorufin dimethylcarbamate
0
*Carbamates
*Oxazines
Aldehyde Dehydrogenase.
Adv Exp Med Biol 1999;463:89-96
NPI 2
0
*Carbamates
*Sulfonamides
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem Pharmacol 1998 Feb 15;55(4):465-74
API 2
0
Chlorpropamide/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem Pharmacol 1998 Feb 15;55(4):465-74
S-
isobutylisothiourea
44744-73-2
Thiourea/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
J Med Chem 1997 Jun 6;40(12):1870-5
S-
n-
butylisothiourea
2986-22-3
Thiourea/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
J Med Chem 1997 Jun 6;40(12):1870-5
Aldh3a1protein, mouse
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Adv Exp Med Biol 1997;414:37-46
indole-
3-
acetaldehyde dehydrogenase, Ustilago maydis
EC 1.2.1.-
*Aldehyde Dehydrogenase
*Fungal Proteins.
Eur J Biochem 1996 Dec 15;242(3):648-56
4-
sulfobenzaldehyde dehydrogenase
EC 1.2.1.-
*Aldehyde Dehydrogenase.
J Bacteriol 1997 Feb;179(3):919-27
GbsA protein, Bacillus subtilis
EC 1.2.1.-
*Aldehyde Dehydrogenase
*Bacterial Proteins.
J Bacteriol 1996 Sep;178(17):5121-9
ALDH2 protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Adv Exp Med Biol 1995;372:131-6
FIS1 protein, Linum usitatissimum
EC 1.2.1.3
*Plant Proteins
Aldehyde Dehydrogenase.
Plant J 1995 Jul;8(1):1-8
4-
(N,N-
dipropylamino)benzaldehyde
613-28-5
*Benzaldehydes
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem Pharmacol 1995 Jul 31;50(3):399-406
btg-
26 protein, Brassica napus
EC 1.1.1.-
*Plant Proteins
Aldehyde Dehydrogenase.
Plant Mol Biol 1995 Feb;27(3):541-51
ALDH7A1 protein, human
EC 1.2.1.3
*Aldehyde Dehydrogenase.
Genomics 1994 May 15;21(2):371-8
S-
methyl-
N,N-
diethylthiolcarbamate sulfone
0
Ditiocarb/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem Pharmacol 1994 Apr 20;47(8):1465-7
S-
methyl N,N-
diethylthiolcarbamate sulfoxide
140703-15-7
Ditiocarb/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem Pharmacol 1992 Feb 4;43(3):403-6
azoxy procarbazine oxidase
EC 1.2.1.-
*Aldehyde Dehydrogenase.
Drug Metab Dispos 1991;19(4):795
dioxiram
59547-11-4 Thioperoxydicarbonic diamide (((H2N)C(O))2S2), tetraethyl
*Carbamates
*Disulfides
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem J 1991;278(Pt 1):189
S-
methyl diethylthiocarbamate
37174-63-3
*Thiocarbamates
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem J 1991;278(Pt 1):189
1-
methyl-
5-
(methyldithio)-
1H-
tetrazole
101554-56-7
*Tetrazoles
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem J 1989;261(1):281
4-
amino-
4-
methyl-
2-
pentyne-
1-
al
121188-32-7
*Aldehydes
Aldehyde Dehydrogenase/antagonists & inhibitors.
Biochem Pharmacol 1989;38(8):1335
phenethyl isothiocyanate
2257-09-2
*Isothiocyanates
Aldehyde Dehydrogenase/antagonists & inhibitors.
Pharma Action
Carcinogens
;
Enzyme Inhibitors
;
Anticarcinogenic Agents
Cancer Res 1989;49(3):549
N(1)-
ethylchlorpropamide
117048-15-4
Chlorpropamide/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
Alcoholism (NY) 1988;12(4):563
thyroid hormone-
binding proteins
0
*Carrier Proteins
*Membrane Proteins
*Thyroid Hormones
Aldehyde Dehydrogenase
Neoplasm Proteins
Triiodothyronine
Xenopus Proteins.
J Histochem Cytochem 1987;35(10):1043
5,5'-
dithiobis(1-
methyltetrazole)
62671-38-9
*Tetrazoles
Alcohol Oxidoreductases/antagonists & inhibitors
Aldehyde Dehydrogenase/antagonists & inhibitors
Mixed Function Oxygenases.
Alcoholism 1986;10(1):27
diethyldithiocarbamic acid methanethiol
22158-12-9 Carbamo(dithioperoxo)thioic acid, diethyl-
, (S)
Ditiocarb/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
FEBS Lett 1985;179(1):77
daunorubicin-
binding protein, rat
EC 1.2.1.-
*Aldehyde Dehydrogenase
*Carrier Proteins
Daunorubicin.
Mol Pharmacol 1983;24(2):336
corneal protein 54, bovine
0
*Aldehyde Dehydrogenase
Eye Proteins
Isoenzymes.
Pharma Action
Antioxidants
Exp Eye Res 1981;32(2):205
methyl diethyldithiocarbamate
686-07-7
Ditiocarb/*analogs & derivatives
Aldehyde Dehydrogenase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
Aviat Space Environ Med 49(5):665;1978