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Antithrombin Proteins

More information in Books or onNLM PubMed
Definition: An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.  ANTITHROMBINS is also available   
Pharmacological Action Antithrombins
Examples Antithrombin III; Heparin Cofactor II; Hirudins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
antithrombin La Rochelle  0   *Antithrombin Proteins. Clin Lab Haematol. 2003 Jun;25(3):191-3
antithrombin London  0   *Antithrombin Proteins. J Biol Chem 2003 Apr 18;278(16):13688-95
dabigatran etexilate  211915-06-9 3-((2-((4-amino((E)-hexyloxycarbonylimino)methyl)-phenylamino)methyl-1-1H-benzoimidazole-5-carbonyl)pyridin-2-yl-amino)propionic acid ethyl ester  *Benzimidazoles *Pyridines Prodrugs Antithrombin Proteins. J Med Chem 2002 Apr 25;45(9):1757-66PRADAXA
L 636619  0   *Antithrombin Proteins. Bioorg Med Chem Lett 1998 Jul 7;8(13);1703-6
tsetse thrombin inhibitor  0   *Insect Proteins *Antithrombin Proteins. Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14290-5
antithrombin Wibble  0   *Antithrombin Proteins. Blood 1998 Oct 15;92(8):2696-706
antithrombin Wobble  0   *Antithrombin Proteins. Blood 1998 Oct 15;92(8):2696-706
L-antithrombin  0   *Antithrombin Proteins. Biochemistry 1997 Oct 21;36(42):13133-42
antithrombin Okayama  0   *Antithrombin Proteins. Thromb Res 1997 Mar 15;85(6):515-7
antithrombin Morioka  0   *Antithrombin Proteins. Thromb Haemost 1997 Feb;77(2):403-7
antithrombin Oslo  0   *Antithrombin Proteins. Blood 1995 Nov 1;86(9):3461-7
antithrombin Glasgow  0   *Antithrombin Proteins. Br J Haematol 1987 Aug;66(4):523-7
antithrombin Rouen-VI  159940-57-5 Antithrombin Rouen VI  *Antithrombin Proteins. J Clin Invest 1994 Dec;94(6):2265-74
antithrombin Rouen IV  129553-81-7 Antithrombin Rouen IV  *Antithrombin Proteins. Febs Lett 1990;266(1-2):163
antithrombin Barcelona 2  123644-73-5 Antithrombin Barcelona 2  *Antithrombin Proteins. Thromb Res 1989;55(4):451
antithrombin Chicago  122653-64-9 Antithrombin Chicago  *Antithrombin Proteins. Thromb Res 1989;54(6):613
antithrombin Pescara  122007-63-0 Antithrombin Pescara  *Antithrombin Proteins. J Biol Chem 1989;264(17):10200
antithrombin III Trento  0   *Antithrombin Proteins. Br J Haematol 1983;55(3):558
antithrombin V  0   *Antithrombin Proteins. Folia Haematol (Leipz) 1983;110(2):278
antithrombin BM protein, human  0   *Antithrombin Proteins. Thromb Res 1982;25(3):177

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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