fms-Like Tyrosine Kinase 3 (definition)

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fms-Like Tyrosine Kinase 3

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Definition: A receptor tyrosine kinase that is involved in HEMATOPOIESIS. It is closely related to FMS PROTO-ONCOGENE PROTEIN and is commonly mutated in acute MYELOID LEUKEMIA.

Other names fms Like Tyrosine Kinase 3; Fetal Liver Kinase 3; Fetal Liver Kinase 2; Antigen, CD135; Stem Cell Tyrosine Kinase 1; Fetal Liver Kinase-3; Fetal Liver Kinase-2; CD135 Antigen; CD135 Antigens; Antigens, CD135

Substance	CAS Registry & name	Categories	Source
11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene	0	Bridged Compounds Pyrimidines fms-Like Tyrosine Kinase 3/antagonists & inhibitors Janus Kinase 2/antagonists & inhibitors.	J Med Chem 2011 Jul 14;54(13):4638-58
FLT3 protein, rat	EC 2.7.1.112	*fms-Like Tyrosine Kinase 3.	J Gastroenterol Hepatol 2007 Dec;22(12):2181-8
Flt3 protein, mouse	EC 2.7.1.112	*fms-Like Tyrosine Kinase 3.
FLT3 protein, human	EC 2.7.10.1	*fms-Like Tyrosine Kinase 3.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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