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Proteasome Endopeptidase Complex

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Definition: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.     
See Also Ubiquitin-Protein Ligase Complexes 		Other names Proteinase, Multicatalytic; Proteasome, 20S; Endopeptidase Complex, Proteasome; Endopeptidase Complex, Multicatalytic; Complex, Proteasome Endopeptidase; Complex, Multicatalytic Endopeptidase; Proteasome; Prosome; Multicatalytic Proteinase; Multicatalytic Endopeptidase Complex; Macroxyproteinase; Macropain; Ingensin; 20S Proteasome
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PSMB2 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. J Nutr Biochem. 2011 Nov;22(11):1003-8
PSMD10 protein, Danio rerio  0   *Proto-Oncogene Proteins *Zebrafish Proteins *Proteasome Endopeptidase Complex. Biochim Biophys Acta. 2011 Sep;1811(9):536-48
PSMB2 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. J Biomed Biotechnol 2011;2011:757960
PSMA6 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Biochem Biophys Commun Res 2011 Apr 22;407(4):668-73
RPN2a protein, Arabidopsis  0   *Arabidopsis Proteins Protein Subunits Proteasome Endopeptidase Complex. J Exp Bot 2011 Jan;62(1):359-69
PSMA6 protein, rat  EC 3.4.25.1   *Proteasome Endopeptidase Complex. Biochem Cell Biol. 2010 Aug;88(4):635-48
Ecm29 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex Protein Subunits. Mol Cell 2010 Jun 25;38(6):879-88
PSMD14 protein, mouse  0   *Trans-Activators *Proteasome Endopeptidase Complex Protein Subunits. J Cell Biochem. 2010 Apr 1;109(5):967-74
PSMD11 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Int J Biochem Cell Biol. 2009 Dec;41(12): 2431-9
proteasome activator PA700 subunit p58, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. Mol Biol Cell 1997 Jan;8(1):171-87
Psmc3 protein, rat  0   *Adenosine Triphosphatases Proteasome Endopeptidase Complex. Dev Dyn 2009 Jul;238(7):1851-61
PR-957  0   *Oligopeptides Proteasome Endopeptidase Complex/antagonists & inhibitors. Nat Med. 2009 Jul;15(7):781-7
PSB7 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. J Proteome Res. 2008 Jul;7(7):2959-72
RPN13 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Nature 2008 May 22;453(7194):481-8
CEP-18770  0   *Boronic Acids Threonine/*analogs & derivatives Proteasome Endopeptidase Complex/antagonists & inhibitors. Blood 2008 Mar 1;111(5):2765-75
proteasome subunit beta5t, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Science 2007 Jun 1;316(5829):1349-53
proteasome subunit beta5t, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Science 2007 Jun 1;316(5829):1349-53
Rpn7 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex Protein Subunits. Mol Biol Cell 2007 Feb;18(2):569-80
Rpn5 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex Protein Subunits. Mol Cell Biol 1998 Jun;18(6):3149-62
RPN2 protein, human  EC 2.4.1.119   *Proteasome Endopeptidase Complex. Biochem J 2007 Mar 1;402(2):367-75
PA28 protein, rat  0   *Proteasome Endopeptidase Complex. FASEB J. 2005 Apr;19(6):644-6
PSMD8 protein, human  0   *Proteasome Endopeptidase Complex.
Blm10 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Nat Struct Mol Biol 2005 Apr;12(4):294-303
RPN1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex.
SCL1 protein, S cerevisiae  EC 3.4.25.1   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex.
PSMD4 protein, human  0   *Proteasome Endopeptidase Complex.
Pros28.1B protein, Drosophila  EC 3.4.25.1   *Drosophila Proteins *Proteasome Endopeptidase Complex. Nucleic Acids Res 2005;33(5):1435-44
KIAA0368 protein, human  0   *Proteasome Endopeptidase Complex. J Biol Chem 2004 Dec 24;279(52):54849-61
Psmc5 protein, mouse  0   *Proteasome Endopeptidase Complex.
PSMD7 protein, human  0   *Proteasome Endopeptidase Complex.
PSMA7 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. FEBS Lett 2004 Jul 2;569(1-3):211-6
PSMA3 protein, human  EC 3.4.25.1   Proteasome Endopeptidase Complex. Mol Cell Biochem 2003 Dec;254(1-2):157-62
Psme2 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
Psme1 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
PSME2 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Muscle Proteins.
SHFM1 protein, human  0   *Proteasome Endopeptidase Complex.
PSMD1 protein, human  0   *Proteasome Endopeptidase Complex Transcription Factors.
Psmb5 protein, rat  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
Psmb5 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
PRE4 protein, S cerevisiae  EC 3.4.25.1   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex.
PSMA6 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. DNA Seq 2001 Nov;12(4):261-5
PSMD10 protein, human  0   *Proto-Oncogene Proteins *Proteasome Endopeptidase Complex Ankyrins. Nat Med 2000 Jan;6(1):96-9
RPN3 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Mol Cell Biol 1999 Oct;19(10):6872-90
RPN10 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Mol Biol Cell 1997 Jan;8(1):171-87; Plant Cell 1999 Aug;11(8):1457-71
26S proteasome non-ATPase regulatory subunit 13  EC 3.6.1.-   *Proteasome Endopeptidase Complex. FEBS Lett 1999 Apr 16;449(1):88-92; Gene 1998 Aug 17;216(1):113-22
SEM1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Proc Natl Acad Sci U S A 1999 Feb 2;96(3):909-14
NAS6 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Gene 1998 Aug 17;216(1):113-22
PSMD9 protein, human  0   *Proteasome Endopeptidase Complex Intracellular Signaling Peptides and Proteins. Genomics 1998 Jun 1;50(2):241-50
PSMD14 protein, human  0   *Trans-Activators *Proteasome Endopeptidase Complex. J Biol Chem 1997 Nov 28;272(48):30470-5
PSMB4 protein, human  EC 3.4.22.-   *Proteasome Endopeptidase Complex Multienzyme Complexes. J Mol Biol 1995 Apr 28;248(2):264-72
RPT4 protein, S cerevisiae  EC 3.6.1.-   *Adenosine Triphosphatases *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. J Biol Chem 1996 Dec 20;271(51):32810-7
Ki antigen  0   *Autoantigens *Proteasome Endopeptidase Complex Antigens, Surface. Clin Exp Immunol 1990 Feb;79(2):209-14
PSMB10 protein, human  EC 3.4.99.46   *Proteasome Endopeptidase Complex. Hum Mol Genet 1993 Oct;2(10):1589-95
RPN2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Mol Cell Biol 1995 Nov;15(11):6311-21
PSMB6 protein, human  EC 3.4.99.46   *Proteasome Endopeptidase Complex Major Histocompatibility Complex. Science 1994 Aug 26;265(5176):1231-4
PSMB5 protein, human  EC 3.4.99.46   *Proteasome Endopeptidase Complex Major Histocompatibility Complex. Science 1994 Aug 26;265(5176):1231-4
PSMC4 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. Biol Chem Hoppe Seyler 1994 Apr;375(4):237-40
PRE3 protein, S cerevisiae  EC 3.4.25.1   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. FEBS Lett 1994 Mar 21;341(2-3):193-6
PA700 proteasome activator  0   *Proteasome Endopeptidase Complex. J Biol Chem 1994 Feb 4;269(5):3539-47
PSME1 protein, human  0   *Muscle Proteins *Proteasome Endopeptidase Complex. Eur J Biochem 1993 Dec I;218(2):421-30
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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