encyclopedia of medical concepts
ψ 
ψ 
ψ 

Proteasome Endopeptidase Complex

More information in Books or onNLM PubMed
Definition: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.     
See Also Ubiquitin-Protein Ligase Complexes
Other names Proteinase, Multicatalytic; Proteasome, 20S; Endopeptidase Complex, Proteasome; Endopeptidase Complex, Multicatalytic; Complex, Proteasome Endopeptidase; Complex, Multicatalytic Endopeptidase; Proteasome; Prosome; Multicatalytic Proteinase; Multicatalytic Endopeptidase Complex; Macroxyproteinase; Macropain; Ingensin; 20S Proteasome
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PSMB2 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. J Nutr Biochem. 2011 Nov;22(11):1003-8
PSMD10 protein, Danio rerio  0   *Proto-Oncogene Proteins *Zebrafish Proteins *Proteasome Endopeptidase Complex. Biochim Biophys Acta. 2011 Sep;1811(9):536-48
PSMB2 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. J Biomed Biotechnol 2011;2011:757960
PSMA6 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Biochem Biophys Commun Res 2011 Apr 22;407(4):668-73
RPN2a protein, Arabidopsis  0   *Arabidopsis Proteins Protein Subunits Proteasome Endopeptidase Complex. J Exp Bot 2011 Jan;62(1):359-69
PSMA6 protein, rat  EC 3.4.25.1   *Proteasome Endopeptidase Complex. Biochem Cell Biol. 2010 Aug;88(4):635-48
Ecm29 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex Protein Subunits. Mol Cell 2010 Jun 25;38(6):879-88
PSMD14 protein, mouse  0   *Trans-Activators *Proteasome Endopeptidase Complex Protein Subunits. J Cell Biochem. 2010 Apr 1;109(5):967-74
PSMD11 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Int J Biochem Cell Biol. 2009 Dec;41(12): 2431-9
proteasome activator PA700 subunit p58, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. Mol Biol Cell 1997 Jan;8(1):171-87
Psmc3 protein, rat  0   *Adenosine Triphosphatases Proteasome Endopeptidase Complex. Dev Dyn 2009 Jul;238(7):1851-61
PR-957  0   *Oligopeptides Proteasome Endopeptidase Complex/antagonists & inhibitors. Nat Med. 2009 Jul;15(7):781-7
PSB7 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. J Proteome Res. 2008 Jul;7(7):2959-72
RPN13 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Nature 2008 May 22;453(7194):481-8
CEP-18770  0   *Boronic Acids Threonine/*analogs & derivatives Proteasome Endopeptidase Complex/antagonists & inhibitors. Blood 2008 Mar 1;111(5):2765-75
proteasome subunit beta5t, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Science 2007 Jun 1;316(5829):1349-53
proteasome subunit beta5t, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. Science 2007 Jun 1;316(5829):1349-53
Rpn7 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex Protein Subunits. Mol Biol Cell 2007 Feb;18(2):569-80
Rpn5 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex Protein Subunits. Mol Cell Biol 1998 Jun;18(6):3149-62
RPN2 protein, human  EC 2.4.1.119   *Proteasome Endopeptidase Complex. Biochem J 2007 Mar 1;402(2):367-75
PA28 protein, rat  0   *Proteasome Endopeptidase Complex. FASEB J. 2005 Apr;19(6):644-6
PSMD8 protein, human  0   *Proteasome Endopeptidase Complex.
Blm10 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Nat Struct Mol Biol 2005 Apr;12(4):294-303
RPN1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex.
SCL1 protein, S cerevisiae  EC 3.4.25.1   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex.
PSMD4 protein, human  0   *Proteasome Endopeptidase Complex.
Pros28.1B protein, Drosophila  EC 3.4.25.1   *Drosophila Proteins *Proteasome Endopeptidase Complex. Nucleic Acids Res 2005;33(5):1435-44
KIAA0368 protein, human  0   *Proteasome Endopeptidase Complex. J Biol Chem 2004 Dec 24;279(52):54849-61
Psmc5 protein, mouse  0   *Proteasome Endopeptidase Complex.
PSMD7 protein, human  0   *Proteasome Endopeptidase Complex.
PSMA7 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Protein Subunits. FEBS Lett 2004 Jul 2;569(1-3):211-6
PSMA3 protein, human  EC 3.4.25.1   Proteasome Endopeptidase Complex. Mol Cell Biochem 2003 Dec;254(1-2):157-62
Psme2 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
Psme1 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
PSME2 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex Muscle Proteins.
SHFM1 protein, human  0   *Proteasome Endopeptidase Complex.
PSMD1 protein, human  0   *Proteasome Endopeptidase Complex Transcription Factors.
Psmb5 protein, rat  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
Psmb5 protein, mouse  EC 3.4.25.1   *Proteasome Endopeptidase Complex.
PRE4 protein, S cerevisiae  EC 3.4.25.1   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex.
PSMA6 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. DNA Seq 2001 Nov;12(4):261-5
PSMD10 protein, human  0   *Proto-Oncogene Proteins *Proteasome Endopeptidase Complex Ankyrins. Nat Med 2000 Jan;6(1):96-9
RPN3 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Mol Cell Biol 1999 Oct;19(10):6872-90
RPN10 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Mol Biol Cell 1997 Jan;8(1):171-87; Plant Cell 1999 Aug;11(8):1457-71
26S proteasome non-ATPase regulatory subunit 13  EC 3.6.1.-   *Proteasome Endopeptidase Complex. FEBS Lett 1999 Apr 16;449(1):88-92; Gene 1998 Aug 17;216(1):113-22
SEM1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Proc Natl Acad Sci U S A 1999 Feb 2;96(3):909-14
NAS6 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Gene 1998 Aug 17;216(1):113-22
PSMD9 protein, human  0   *Proteasome Endopeptidase Complex Intracellular Signaling Peptides and Proteins. Genomics 1998 Jun 1;50(2):241-50
PSMD14 protein, human  0   *Trans-Activators *Proteasome Endopeptidase Complex. J Biol Chem 1997 Nov 28;272(48):30470-5
PSMB4 protein, human  EC 3.4.22.-   *Proteasome Endopeptidase Complex Multienzyme Complexes. J Mol Biol 1995 Apr 28;248(2):264-72
RPT4 protein, S cerevisiae  EC 3.6.1.-   *Adenosine Triphosphatases *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. J Biol Chem 1996 Dec 20;271(51):32810-7
Ki antigen  0   *Autoantigens *Proteasome Endopeptidase Complex Antigens, Surface. Clin Exp Immunol 1990 Feb;79(2):209-14
PSMB10 protein, human  EC 3.4.99.46   *Proteasome Endopeptidase Complex. Hum Mol Genet 1993 Oct;2(10):1589-95
RPN2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. Mol Cell Biol 1995 Nov;15(11):6311-21
PSMB6 protein, human  EC 3.4.99.46   *Proteasome Endopeptidase Complex Major Histocompatibility Complex. Science 1994 Aug 26;265(5176):1231-4
PSMB5 protein, human  EC 3.4.99.46   *Proteasome Endopeptidase Complex Major Histocompatibility Complex. Science 1994 Aug 26;265(5176):1231-4
PSMC4 protein, human  EC 3.4.25.1   *Proteasome Endopeptidase Complex. Biol Chem Hoppe Seyler 1994 Apr;375(4):237-40
PRE3 protein, S cerevisiae  EC 3.4.25.1   *Saccharomyces cerevisiae Proteins *Proteasome Endopeptidase Complex. FEBS Lett 1994 Mar 21;341(2-3):193-6
PA700 proteasome activator  0   *Proteasome Endopeptidase Complex. J Biol Chem 1994 Feb 4;269(5):3539-47
PSME1 protein, human  0   *Muscle Proteins *Proteasome Endopeptidase Complex. Eur J Biochem 1993 Dec I;218(2):421-30
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify.
We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy