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Proto-Oncogene Proteins c-raf

More information in Books or onNLM PubMed
Definition: A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.     
See Also Oncogene Proteins v-raf 		Other names raf 1 Kinase; c-raf, Proto-Oncogene Proteins; c-raf, Proto-Oncogene Protein; c raf Proteins; c raf Kinases; Raf-1, Kinase; Proto Oncogene Proteins c raf; Proto Oncogene Protein c raf; Proteins, c-raf; Proteins c-raf, Proto-Oncogene; Protein c-raf, Proto-Oncogene; Kinases, c-raf; Kinase, raf-1; Kinase, cRaf1; Kinase Raf 1; raf-1 Kinase; cRaf1 Kinase; c-raf Kinases; Proto-Oncogene Protein c-raf; Kinase p74(raf-1)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BHC80 protein, mouse  EC 3.5.1.-   *Histone Deacetylases *Proto-Oncogene Proteins c-raf. Biochem Biophys Res Commun 2004 Sep 17;322(2):601-8
5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone  0   *Indoles *Phenols Proto-Oncogene Proteins c-raf/antagonists & inhibitors. J Neurochem 2004 Aug;90(3):595-608
lin-45 protein, C elegans  EC 2.7.1.-   *Caenorhabditis elegans Proteins *raf Kinases Signal Transduction Proto-Oncogene Proteins c-raf. Nature 1993 May 13;363(6425):133-40
c-mil protein, Gallus gallus  0   *Proto-Oncogene Proteins c-raf *Avian Proteins.
phl protein, Drosophila  0   *Proto-Oncogene Proteins c-raf *Drosophila Proteins.
proto-oncogene protein v-RAF1, pig  0   *Proto-Oncogene Proteins c-raf. Mamm Genome 1997 Aug;8(8):626-7
ISIS 5132  0   *Thionucleotides Proto-Oncogene Proteins c-raf/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Nat Med 1996 Jun;2(6):668-74
Ras-dependent mitogen-activated protein kinase kinase kinase  EC 2.7.10.-   *MAP Kinase Kinase Kinases *Extracellular Signal-Regulated MAP Kinases Proto-Oncogene Proteins c-raf. J Biol Chem 1994 Sep 16;269(37):22917-20

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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