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Sodium-Calcium Exchanger

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Definition: An electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.  DF: NA CA EXCHANGER    Other names Sodium Calcium Exchanger; Sodium Calcium Carrier; Sodium Calcium Antiporter; Exchanger, Sodium-Calcium; Exchanger, Calcium-Sodium; Carrier, Sodium-Calcium; Carrier, Calcium-Sodium; Calcium Sodium Exchanger; Calcium Sodium Carrier; Calcium Sodium Antiporter; Antiporter, Sodium-Calcium; Antiporter, Calcium-Sodium; Sodium-Calcium Antiporter; Na(+)-Ca(2+) Antiporter; Calcium-Sodium Antiporter; Ca(2+)-Na(+) Antiporter; Sodium-Calcium Carrier; Na(+)-Ca(2+) Exchanger; Calcium-Sodium Exchanger; Calcium-Sodium Carrier
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(3-aminobenzyl)-6-(4-((3-fluorobenzyl)oxy)phenoxy)nicotinamide  0   Niacinamide/*analogs & derivatives Sodium-Calcium Exchanger/antagonists & inhibitors. Mol Pharmacol 2006 Dec;70(6):2075-83
Slc24a3 protein, rat  0   *Sodium-Calcium Exchanger.
Slc24a3 protein, mouse  0   *Sodium-Calcium Exchanger.
NCX1 protein, mouse  0   *Sodium-Calcium Exchanger. Circ Res 2004 Sep 17;95(6):604-11
Slc8a2 protein, mouse  0   *Sodium-Calcium Exchanger.
Slc8a3 protein, rat  0   *Sodium-Calcium Exchanger.
Slc8a3 protein, mouse  0   *Sodium-Calcium Exchanger.
SLC24A6 protein, human  0   *Sodium-Calcium Exchanger. J Biol Chem 2004 Feb 13;279(7):5867-76
SEA 0400  0   *Aniline Compounds *Phenyl Ethers Sodium-Calcium Exchanger/antagonists & inhibitors. J Pharmacol Exp Ther 2001 Jul;298(1):249-56
SLC24A3 protein, human  0   *Sodium-Calcium Exchanger. J Biol Chem 2001 Jun 22;276(25):23161-72
callipeltin A  0   *Depsipeptides Sodium-Calcium Exchanger/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Dec 9;279(1):219-22
NCX10 protein, rat  0   *Sodium-Calcium Exchanger Protein Isoforms. Calcif Tissue Int 2000 Jul;67(1):60-7
Slc8a2 protein, rat  0   *Sodium-Calcium Exchanger. Am J Physiol 1998 Feb;274( 2 Pt 1):C415-23
sodium-calcium exchanger 1  0   *Sodium-Calcium Exchanger. Am J Physiol 1998 Jan;274(1 Pt 2):H217-32
SLC38A3 protein, human  0   *Sodium-Calcium Exchanger. J Biol Chem 1996 Oct 4;271(40):24914-21
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate  0   Thiourea/*analogs & derivatives Sodium-Calcium Exchanger/antagonists & inhibitors.
Pharma Action Anti-Arrhythmia Agents 		J Biol Chem 1996 Sep 13;271(37):22391-7
potassium-dependent sodium-calcium exchanger  147478-17-9   *Sodium-Calcium Exchanger Rod Cell Outer Segment Drosophila Proteins. EMBO J 1992 May;11(5):1689-95
2',4'-dichlorobenzamil amiloride  90689-42-2   Amiloride/*analogs & derivatives Sodium-Calcium Exchanger/antagonists & inhibitors. J Physiol (Lond) 1990;422:481
5-dimethylamiloride  1214-79-5   Amiloride/*analogs & derivatives Sodium-Calcium Exchanger/antagonists & inhibitors. J Membr Biol 1983;75(3):179

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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