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Receptors, Neurokinin-3

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Definition: A class of cell surface receptors for tachykinins that prefers neurokinin B (neurokinin beta, neuromedin K) over other tachykinins. Neurokinin-3 (NK-3) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They have been found in the central nervous system and in peripheral tissues.  tachykinin receptors; DF: RECEPT NEUROKININ 3    Other names Receptors, NK-3; Neurokinin-3 Receptors; Neurokinin B Receptors; NK-3 Receptors; Receptors, Neurokinin B; Receptors, Neurokinin 3; Receptors, NK 3; Receptor, Neuromedin K; Receptor, Neurokinin-3; Receptor, NK-3; Neuromedin K Receptors; Neurokinin 3 Receptors; Neurokinin 3 Receptor; NK 3 Receptors; NK 3 Receptor; K Receptors, Neuromedin; B Receptors, Neurokinin; Receptors, Neuromedin K; Neuromedin K Receptor; Neurokinin-3 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-((methylsulfonyl)amino)-2-phenyl-N-(1-phenylpropyl)quinolin-4-carboxamide  0   *Aminoquinolines *Sulfonamides Receptors, Neurokinin-3/antagonists & inhibitors. Xenobiotica 2010 Nov;40(11):721-9
N-(alpha-ethylbenzyl)-3-(carboxymethoxy)-2-phenylquinoline-4-carboxamide  0   *Acetic Acids *Quinolines Receptors, Neurokinin-3/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Jan;300(1):314-23
SB 414240  0   *Piperidines *Quinolines Receptors, Neurokinin-2/antagonists & inhibitors Receptors, Neurokinin-3/antagonists & inhibitors. J Med Chem 2001 May 24;44(11):1675-89
SB 400238  0   *Morpholines *Quinolines Receptors, Neurokinin-2/antagonists & inhibitors Receptors, Neurokinin-3/antagonists & inhibitors. J Med Chem 2001 May 24;44(11):1675-89
MEN 11575  0   *Oligopeptides Receptors, Neurokinin-3/antagonists & inhibitors. J Med Chem 1999 Feb 11;42(3):409-14
CAM 5187  0   *Carbamates Urea/*analogs & derivatives Receptors, Neurokinin-3/antagonists & inhibitors. J Pharm Biomed Anal 1998 Mar;16(7):1171-8
CAM 5500  0   *Carbamates *Morpholines Receptors, Neurokinin-3/antagonists & inhibitors. J Pharm Biomed Anal 1998 Mar;16(7):1171-8
R 820  0   *Indoles *Oligopeptides Receptors, Tachykinin/antagonists & inhibitors Receptors, Neurokinin-3/antagonists & inhibitors. Br J Pharmacol 1997 Oct;122(4):643-54
SB 222200  0   *Quinolines Receptors, Neurokinin-3/antagonists & inhibitors. Br J Pharmacol 1997 Oct;122(3):469-76
SB 223412  174636-32-9   *Quinolines Receptors, Neurokinin-3/antagonists & inhibitors. J Pharmacol Exp Ther 1997 Jun;281(3):1303-11
SB 218795  0   *Quinolines Receptors, Neurokinin-3/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1794-807
PD 154740  159614-69-4   *Dipeptides Phenylalanine/*analogs & derivatives Receptors, Neurokinin-3/antagonists & inhibitors. Mol Pharmacol 1995 Oct;48(4):711-6
substance P, Sar(9)-Met(O2)(11)  110880-55-2   Substance P/*analogs & derivatives Receptors, Neurokinin-3/antagonists & inhibitors. Naunyn Schmiedebergs Arch Pharmacol 1989;340(5):547
substance P (5-11), Asp(5,6)-MePhe(8)  104499-97-0   *Peptide Fragments Substance P/*analogs & derivatives Receptors, Neurokinin-3/antagonists & inhibitors. Neurosci Lett 1988;92(3):341

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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