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Receptors, Fibroblast Growth Factor

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Definition: Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.  coord IM with specific FIBROBLAST GROWTH FACTORS (IM); DF: note short X ref   
Examples Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Fibroblast Growth Factor, Type 4; Receptor, Fibroblast Growth Factor, Type 5 		Other names Receptors, FGF; Fibroblast Growth Factor Receptors; FGF Receptors; Receptor, FGF; Heparin Binding Growth Factor Receptor; Heparin-Binding Growth Factor Receptor; Fibroblast Growth Factor Receptor; FGF Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3yl)vinyl)-1H-pyrazol-1-yl)ethanol  0   *Indazoles Receptors, Fibroblast Growth Factor/antagonists & inhibitors. Mol Cancer Ther. 2011 Nov;10(11):2200-10.
msFGFR2 protein  0   *Peptide Fragments *Recombinant Proteins *Receptor, Fibroblast Growth Factor, Type 2 Receptors, Fibroblast Growth Factor/antagonists & inhibitors. Mol Cancer Ther. 2011 Sep;10(9):1656-66.
elcamin 1 peptide  0   *Peptides Receptors, Fibroblast Growth Factor/agonists. J Neurosci Res 2009 Jun;87(8):1806-12
fibroblast growth factor-21 receptor, mouse  0   *Receptors, Fibroblast Growth Factor. J Cell Physiol 2008 Apr;215(1):1-7
Fgfrl1b protein, zebrafish  0   *Receptors, Fibroblast Growth Factor *Zebrafish Proteins. J Biol Chem 2003 Sep 5;278(36):33857-65
Fgfrl1a protein, zebrafish  0   *Receptors, Fibroblast Growth Factor *Zebrafish Proteins. J Biol Chem 2003 Sep 5;278(36):33857-65
5-(6-(5-(difluoro(methylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)-5-isopropylpyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide  0   *Oxadiazoles *Triazines Receptors, Fibroblast Growth Factor/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. J Med Chem 2005 Jun 16;48(12):3991-4008
2,4-difluoro-5-(5-isopropyl-6-(5-(methylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-N-methoxybenzamide  0   *Oxadiazoles *Triazines Receptors, Fibroblast Growth Factor/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. J Med Chem 2005 Jun 16;48(12):3991-4008
5-(6-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-5-isopropylpyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide  0   *Oxadiazoles *Triazines Receptors, Fibroblast Growth Factor/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. J Med Chem 2005 Jun 16;48(12):3991-4008
FGFRL1 protein, Xenopus  0   *Receptors, Fibroblast Growth Factor *Xenopus Proteins. Dev Dyn 2004 Aug;230(4):700-7
FOP-FGFR1 fusion protein, human  0   *Oncogene Proteins, Fusion *Receptors, Fibroblast Growth Factor. Mol Cell Biol 2001 Dec;21(23):8129-42
fibroblast growth factor receptor, Halocynthia roretzi  0   *Receptors, Fibroblast Growth Factor. Development 2001 Jul;128(14):2711-21
FGFR1OP protein, human  0   *Proto-Oncogene Proteins Oncogene Proteins, Fusion Receptors, Fibroblast Growth Factor. Blood 1999 Feb 15;93(4):1381-9
PD 173074  0   *Pyrimidines Receptors, Fibroblast Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. EMBO J 1998 Oct 15;17(20):5896-904
EGL-15 protein, C elegans  0   *Receptors, Fibroblast Growth Factor *Caenorhabditis elegans Proteins. Genes Dev 1998 May 15;12(10):1425-37
heartless protein, Drosophila  EC 2.7.1.112   *Protein-Tyrosine Kinases *Receptors, Fibroblast Growth Factor *Drosophila Proteins. EMBO J 1992 Feb;11(2):391-404; Genes Dev 1996 Dec 1;10(23):3003-17
breathless protein, Drosophila  EC 2.7.1.112   *Protein-Tyrosine Kinases *Receptors, Fibroblast Growth Factor *Drosophila Proteins. Genes Dev 1996 Nov 15;10(22):2912-21
fibroblast growth factor receptor-like embryonic kinase  EC 2.7.1.-   *Receptors, Fibroblast Growth Factor *Receptor Protein-Tyrosine Kinases. Development 1994 Mar;120(3):683-94
cysteine-rich fibroblast growth factor receptor  0   *Sialoglycoproteins *Receptors, Fibroblast Growth Factor. Brain Res 1993 Dec 31;632(1-2):105-13
Cek3 protein, chicken  EC 2.7.1.-   *Receptors, Fibroblast Growth Factor *Receptor Protein-Tyrosine Kinases. Cell Growth Differ 1992 Jun;3(6):355-61

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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