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ψ 
ψ 
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Receptors, Opioid, mu

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Definition: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.  opioid receptors found in the hypothalamus; DF: RECEPT MU    Other names mu Receptors; Receptors, mu Opioid; Receptors, Morphine; Opioid Receptors, mu; Morphine Receptors; Receptors, mu; mu Opioid Receptors; Receptor, mu Opioid; Receptor, mu; Receptor, Morphine; Opioid Receptor, mu; mu Receptor; mu Opioid Receptor; Morphine Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tyrosyl-phenylalanyl-glycyl-tryptophyl-N-methylnorleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Cholecystokinin/antagonists & inhibitors Receptors, Opioid, delta/agonists. Life Sci. 2003 Jun 27;73(6):699-704.
N-naphthoyl-beta-naltrexamine  0   Naltrexone/*analogs & derivatives Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Med Chem. 2012 Jan 26;55(2):
Dmt-NMe-Ala-Aba-Gly-NH2  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem. 2011 Nov 24;54(22):7848-59.
N-((3,5-difluoro-3'-(1H-1,2,4-triazol-3-yl)-4-biphenylyl)methyl)-2,3-dihydro-1H-inden-2-amine  0   *Indans *Triazoles Receptors, Opioid, mu. J Pharmacol Exp Ther. 2011 Oct;339(1):24-34.
KNT 93  0   *Bridged Compounds Naltrexone/*analogs & derivatives Receptors, Opioid, mu/agonists. Bioorg Med Chem Lett 2011 Jul 1;21(13):4023-6
eribis peptide 94  0   *Enkephalins Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. Eur J Pharmacol 2011 Jan 25;651(1-3):146-51
morphiceptin, Dmt(1)-NMeAla(2)-1-Nal(3)  0   *Endorphins Ligands Receptors, Opioid, mu. Peptides 2010 Aug;31(8):1617-24
morphiceptin, Dmt(1)-Ala(2)-1-Nal(3)  0   *Endorphins Ligands Receptors, Opioid, mu. Peptides 2010 Aug;31(8):1617-24
17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-((3'-isoquinolyl)acetamido)morphinan  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2009 Mar 12;52(5):1416-27
17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-((4'-pyridyl)acetamido)morphinan  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2009 Mar 12;52(5):1416-27
phenylethyl orvinol  0   *Morphinans Carbon Radioisotopes Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Med Chem 2009 Sep 24;52(18):5586-9
phenylalanyl-cysteinyl-tryptophyl-arginyl-threonyl-penicillamine-threoninamide  0   *Oligopeptides Receptors, Opioid, mu/antagonists & inhibitors. Neuroscience 2009 Aug 18;162(2):224-33
(N-allyl-Dmt(1))endomorphin-2  0   *Oligopeptides Receptors, Opioid, mu/antagonists & inhibitors. Alcohol Alcohol 2009 Jan-Feb;44(1):13-9
1-(N-cyclobutylmethylmorphinan-3-yl)-10-(N-cyclobutylmethylmorphinan-3-yl)sebacolyate  0   *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. Neurochem Res 2008 Oct;33(10):2142-50
methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate  0   *Secologanin Tryptamine Alkaloids Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. Neuropharmacology 2008 Aug;55(2):154-65
6-desoxymorphine  0   *Morphine Derivatives Receptors, Opioid, mu/agonists. J Med Chem 2008 Apr 10;51(7):2316-20
1-(10-((E)-3-phenyl-allyl)-3,10-diaza-bicyclo(4.3.1)dec-3-yl)propan-1-one  0   *Azabicyclo Compounds Receptors, Opioid, mu/agonists. Neuropharmacology 2008 Feb;54(2):331-43
bis(N-cyclobutylmethylmorphinan-3-yl) sebacoylate dihydrochloride  0   *Alkanes *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/antagonists & inhibitors Receptors, Opioid, kappa/agonists. Pharmacology. 2008;81(3):229-35
9-hydroxy-5-(3-hydroxyphenyl)-2-phenylethyl-2-azabicyclo(3.3.1)nonane  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2007 Aug 9;50(16):3765-76
3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol  0   *Phenols Receptors, Opioid, mu/agonists. J Pharmacol Exp Ther 2007 Oct;323(1):265-76NUCYNTA; NUCYNTA ER
tyrosyl-alanyl-glycyl-phenylalanyl-norleucyl-prolyl-leucyl-tryptophyl-O-3,5-benzyl(CF3)2  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists Receptors, Neurokinin-1/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2779-86
tyrosyl-alanyl-glycyl-phenylalanyl-methionyl-prolyl-leucyl-tryptophyl-O-3,5-benzyl(CF3)2  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists Receptors, Neurokinin-1/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2779-86
tyrosyl-cyclo(allylglycyl-phenylalanyl-allylglycyl)amide  0   *Peptides, Cyclic Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2007 Mar 22;50(6):1414-7
endomorphin-2, Dmt(1)-2-Nal(4)  0   *Oligopeptides Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2007 Feb 8;50(3):512-20
endomorphin-1, Dmt(1)-2-Nal(4)  0   *Oligopeptides Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2007 Feb 8;50(3):512-20
3-(7,8-dimethyl-2-(2-chlorobenzyl)octahydro-1H-pyrido(1,2-a)pyrazin-8-yl)phenol  0   *Pyrazines *Pyridines Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2006 Dec 14;49(25):7290-306
N-ethyl-4-((8-phenethyl-8-azabicyclo(3.2.1)oct-3-ylidene)phenylmethyl)benzamide  0   *Bicyclo Compounds, Heterocyclic Receptors, Opioid, mu/agonists. J Pharmacol Exp Ther 2006 Sep;318(3):1273-9
endomorphin-2, 1-Nal(4)  0   *Oligopeptides Receptors, Opioid, mu/antagonists & inhibitors. Life Sci 2006 Aug 8;79(11):1094-9
tyrosyl-norleucyl-glycyl-tryptophyl-norleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Cholecystokinin/antagonists & inhibitors Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2006 May 18;49(10):2868-75
tyrosyl-alanyl-glycyl-tryptophyl-N-methylnorleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2006 May 18;49(10):2868-75
3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone  0   *Peptides *Pyrazines Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2005 Dec 15;48(25):8035-44
1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane  0   *Diamines *Peptides Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2005 Dec 15;48(25):8035-44
bis(N-cyclobutylmethylmorphinan)fumarate  0   *Fumarates *Morphinans Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Pharmacol Exp Ther 2005 Nov;315(2):821-7
9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester  0   *Furans *Pyrones Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2005 Jul 28;48(15):4765-71
14-benzyloxy-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one  0   Oxymorphone/*analogs & derivatives Receptors, Opioid, mu/agonists. J Med Chem 2005 May 5;48(9):3372-8
17,17'-bis(cyclopropylmethyl)-6,6',7,7'-tetrahydro-4,5-4',5'-diepoxy-6,6'-(benzylimino)(7,7'-bimorphinan)-3,3',14,14'-tetrol  0   Naltrexone/*analogs & derivatives Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2005 Mar 10;48(5):1676-9
PKCI protein, mouse  0   *Receptors, Opioid, mu. Mol Pharmacol. 2004 Nov;66(5):1285-92
cyclo(tyrosyl-prolyl-tryptophyl-phenylalanyl-glycyl)  0   *Peptides, Cyclic Receptors, Opioid, mu/agonists. J Med Chem 2004 Oct 7;47(21):5198-203
N(1)-(2',6'-dimethyltyrosyl-arginyl-phenylalanyl-lysyl)-N(2)-(tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-psi(CH2NH)-cyclohexylalanyl-phenylalanyl)ethylenediamine  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Pept Res 2004 Feb;63(2):63-8
Oprm1 protein, rat  0   *Receptors, Opioid, mu.
OPRM1 protein, human  0   *Receptors, Opioid, mu.
5'-(4-chlorophenyl)-6,7-didehydro-4,5alpha-epoxy-3-hydroxy-17-methylpyrido(2',3'-6,7)morphinan  0   *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1400-12
3-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(4-fluorophenyl)-N-methylbenzamide  0   *Benzamides *Piperazines Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2003 Feb 13;46(4):623-33
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-glycine N-benzylamide  0   *Oligopeptides *Tetrahydroisoquinolines Ligands Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):713-20
4-tyrosylamido-6-benzyl-1,2,3,4 tetrahydroquinoline  0   *Quinolines Receptors, Opioid, mu/agonists. Life Sci 2001 May 4;68(24):2685-94
alvimopan  0   *Piperidines Gastrointestinal Agents Receptors, Opioid, mu. Clin Pharmacol Ther. 2001 Jan;69(1):66-71ENTEREG
JOM 6  0   *Peptides, Cyclic Receptors, Opioid, mu/agonists. J Pharmacol Exp Ther 2000 Dec;295(3):960-6
3-deoxyclocinnamox  0   *Morphine Derivatives Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2000 Aug 24;43(17):3348-50
cyclo(prolyl-1-naphthylalanyl-tryptophyl-tyrosyl-threonyl-phenylalanyl)  0   *Peptides, Cyclic Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2000 Feb 24;43(4):551-9
Oprm protein, mouse  0   *Receptors, Opioid, mu. FEBS Lett 2000 Jan 28;466(2-3):337-40
tyrosyl-cyclo(lysyl-phenylalanyl-alanyl)  0   *Peptides, Cyclic Receptors, Opioid, mu/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Dec 20;9(24):3441-6
2',6'-dimethyltyrosyl--1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-psi(CH2MH)-phenylalanyl-phenylalaninamide  0   *Oligopeptides *Tetrahydroisoquinolines Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 1999 Sep 9;42(18):3520-6
2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalaninamide  0   *Oligopeptides *Tetrahydroisoquinolines Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 1999 Sep 9;42(18):3520-6
tyrosyl-1,2,3,4-tetrahydro--3-isoquinolinecarbonyl-phenylalanyl-phenylalaninamide  0   *Oligopeptides *Tetrahydroisoquinolines Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 1998 Dec 17;41(26):5167-76
tyrosyl-ornithyl-phenylalanyl-glycine  0   *Oligopeptides Receptors, Opioid, mu/agonists. Biull Eksp Biol Med 1997 Feb;123(2):212-5
N-cyclopropylmethyl-5-methyl-14-(4-chlorocinnamoylamino)-7,8-dihydronormorphinone  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. Eur J Pharmacol 1997 Feb 12;320(2-3):121-9
5-methyl-14-(4-chlorocinnamoylamino)-7,8-dihydromorphinone  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. Eur J Pharmacol 1997 Feb 12;320(2-3):121-9
endomorphin 2  0   *Oligopeptides Receptors, Opioid, mu/agonists.
Pharma Action Analgesics, Opioid 		Nature 1997 Apr 3;386(6624):499-502
endomorphin 1  0   *Oligopeptides Receptors, Opioid, mu/agonists.
Pharma Action Analgesics, Opioid 		Nature 1997 Apr 3;386(6624):499-502
tyrosyl-alanyl-phenylalanyl-phenylalaninamide  0   *Oligopeptides Receptors, Opioid, mu/agonists. Br J Pharmacol 1996 Jul;118(6):239-44
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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