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Alternative Splicing

More information in Books or onNLM PubMed
Definition: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.  for NESTED TRANSCRIPTS also index the RNA; do not confuse with NESTED GENES; for nested primers use NESTED PCR; (POLYMERASE CHAIN REACTION)   
See Also Nested Genes; Protein Isoforms; RNA Splice Sites
Other names Alternate Splicing; Splicing, Alternative; RNA Splicing, Alternative; Transcripts, Nested; Transcript, Nested; Splicings, Alternative RNA; Splicings, Alternative; Splicings, Alternate; Splicing, Alternative RNA; Splicing, Alternate; RNA Splicings, Alternative; Nested Transcript; Alternative Splicings; Alternative RNA Splicings; Alternative RNA Splicing; Alternate Splicings; Nested Transcripts
 
SubstanceCAS Registry & nameCategoriesSource
indeterminate(ID)-domain 14 protein, Arabidopsis  0   *Arabidopsis Proteins *Transcription Factors Alternative Splicing. Nat Commun. 2011;2() (dup#5):303
Mafg protein, rat  0   *Repressor Proteins *MafG Transcription Factor Alternative Splicing.
Zmynd11 protein, mouse  0   *Carrier Proteins Zinc Fingers Alternative Splicing.
GAAP-1 protein, human  0   *Trans-Activators *Apoptosis Regulatory Proteins Alternative Splicing. EMBO Rep 2002 Feb;3(2):153-8
FSH-R3 protein, Ovis aries  0   *Receptors, Somatotropin Alternative Splicing. Mol Cell Biol Res Commun 1999 Jul;2(1):21-7
ZMYND11 protein, human  0   *Carrier Proteins Zinc Fingers Alternative Splicing. EMBO J 1995 Jul 3;14(13):3159-69

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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