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Receptors, Somatotropin

More information in Books or onNLM PubMed
Definition: Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.  DF: RECEPT SOMATOTROPIN    Other names Somatotropin Receptors; Somatomammotropin Receptors; Receptors, Growth Hormone; Growth Hormone Receptors; Hormone Receptors, Growth; Hormone Receptor, Growth; Somatotropin Receptor; Somatomammotropin Receptor; Receptors, Somatomammotropin; Receptor, Growth Hormone; Growth Hormone Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GHR1 protein, zebrafish  0   *Receptors, Somatotropin *Zebrafish Proteins. Mol Cell Endocrinol 2011 Apr 30;337(1-2):114-21
(4-(3,4-difluorophenyl)-piperazine-1-yl)-(2-(3-(6-methoxypyridin- 3-yl)-2-methylpropyl)decahydroisoquinoline-4-yl)methanone  0   *Isoquinolines Receptors, Somatotropin/antagonists & inhibitors. J Neurosci 2010 Mar 24;30(12):4306-14
growth hormone receptor (1-241)  0   *Peptide Fragments *Receptors, Somatotropin. Endocrinology 2007 Feb;14(2):824-30
FSH-R3 protein, Ovis aries  0   *Receptors, Somatotropin Alternative Splicing. Mol Cell Biol Res Commun 1999 Jul;2(1):21-7
pegvisomant  0   Human Growth Hormone/*analogs & derivatives Acromegaly Receptors, Somatotropin/antagonists & inhibitors. N Engl J Med 2000 Apr 20;342(16):1171-7SOMAVERT
G120K-PEG  0   *Polyethylene Glycols Receptors, Somatotropin/antagonists & inhibitors. Diabetes 1999 Feb;48(2):377-82
plerocercoid growth factor  0   *Intercellular Signaling Peptides and Proteins Cysteine Endopeptidases Growth Substances Receptors, Somatotropin/agonists. J Parasitol 1984;70(5):840

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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