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Mifepristone

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Definition: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.     
Pharmacological Action Abortifacient Agents, Steroidal; Contraceptives, Oral, Synthetic; Contraceptives, Postcoital, Synthetic; Hormone Antagonists; Luteolytic Agents; Menstruation-Inducing Agents 		Other names RU486; ZK 98296; RU38486; RU 486; RU 38486; R 38486; Mifepristone Exelgyn Brand; Mifepristone Danco Brand; Mifepristone Contragest Brand; ZK98296; ZK-98296; RU-486; RU-38486; R38486; R-38486; Mif+¬gyne; Mifeprex; Mifegyne; Exelgyn Brand of Mifepristone; Danco Brand of MifepristoneDrugs* : MIFEPREX; KORLYM
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Corlux  0   *Mifepristone.
RU49953  0   Mifepristone/*analogs & derivatives. J Neurochem 2001 Feb;76(4):1121-8
11-(4-acetophenyl)-17-hydroxy-17-(3-methyl-1-butynyl)-4,9-estradien-3-one  0   Mifepristone/*analogs & derivatives. Steroids 2000 Mar;65(3):157-62
11-(4-dimethylaminophenyl)-17-hydroxy-17-(3-methyl-1-butynyl)-4,9-estradien-3-one  0   Mifepristone/*analogs & derivatives. Steroids 2000 Mar;65(3):157-62
RU 46534  0   Mifepristone/*analogs & derivatives Progestins/antagonists & inhibitors Receptors, Progesterone/antagonists & inhibitors. J Reprod Fertil Suppl 1997;51:317-25
ZK 114043  134235-42-0   Mifepristone/*analogs & derivatives. J Cell Physiol 1995 Jul;164(1):1-8
4'-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one  156383-09-4   Mifepristone/*analogs & derivatives. Steroids 1994 Mar;59(3):185-9
RU 42848  104004-92-4   Mifepristone/*analogs & derivatives. Contraception 1993 Aug;48(2):133-49
RU 42698  105012-15-5   Mifepristone/*analogs & derivatives. Contraception 1993 Aug;48(2):133-49
RU 40555  145380-08-1   Mifepristone/*analogs & derivatives. J Rheumatol 1992 Feb;19(2):216-22
ZK 112993  105114-63-4   Mifepristone/*analogs & derivatives.
Pharma Action Antineoplastic Agents 		Anticancer Res 1990;10(3):683
Ru 42633  104004-96-8   Mifepristone/*analogs & derivatives. Prog Clin Biol Res 1989;300:445
RU 45196  121548-81-0   Mifepristone/*analogs & derivatives. J Steroid Biochem;32(3):347
mifepristone methochloride  109345-60-0   Mifepristone/*analogs & derivatives. Ophthalmic Res 1987;19(1):61

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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