Definition: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
coord with GENES, DOMINANT or GENES, RECESSIVE if discussed
Other names X-Linked, Spastic Paraplegia, Hereditary; Hereditary Spastic Paraplegia; X linked Recessive Hereditary Spastic Paraplegia; Spastic Paraplegias, Hereditary; Spastic Paraplegia Hypertrophic Motor Sensory Neur; Paraplegias, Hereditary Spastic; Paraplegia, Hereditary Spastic; Hypertrophic Motor Sensory Neuropathy Spastic Para; Hereditary X Linked Recessive Spastic Paraplegia; Hereditary Spastic Paraplegias; Hereditary Motor Sensory Neuropathy with Pyramidal; Charcot Marie Tooth Disease with Pyramidal Feature; X-linked Recessive Hereditary Spastic Paraplegia; Type V Hereditary Motor and Sensory Neuropathy; Spastic Paraplegia-Hypertrophic Motor-Sensory Neur; Spastic Paraplegia, X-Linked Recessive, Hereditary; Type V, HMSN; Spastic Paraplegia, Hereditary, X-Linked Recessive; Spastic Paraplegia, Hereditary, Autosomal Recessiv; Spastic Paraplegia, Hereditary, Autosomal Dominant