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Thioredoxins

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Definition: Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.     
Examples Chloroplast Thioredoxins; Thioredoxin h 		Other names Thioredoxin-2; Thioredoxin-1; Thioredoxin 2; Thioredoxin 1; Thioredoxin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Trx-2 protein, C elegans  0   *Thioredoxins *Caenorhabditis elegans Proteins. Aging Cell 2010 Jun;9(3):420-32
thioredoxin h9, Arabidopsis  0   *Thioredoxins *Arabidopsis Proteins Membrane Proteins. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3900-5
Trx3 protein, S cerevisiae  0   *Thioredoxins *Saccharomyces cerevisiae Proteins. Biochim Biophys Acta 2009 Apr;1794(4):716-21
Trx1 protein, S pombe  0   *Thioredoxins *Schizosaccharomyces pombe Proteins. Biochim Biophys Acta 2001 Mar 19;1518(1-2):194-9
quiescin Q6 sulfhydyl oxidase 1, rat  EC 1.8.3.2   *Thioredoxins. Exp Cell Res 2007 Nov 15;313(19):3971-82
RdCVF protein, mouse  0   *Eye Proteins *Thioredoxins. BMC Mol Biol 2007;8:74
RdCVF-2 protein, mouse  0   *Eye Proteins *Thioredoxins. BMC Mol Biol 2007;8:74
TrxA protein, E coli  0   *Thioredoxins *Escherichia coli Proteins. Gene 1984 Dec;32(3):399-408
Txn2 protein, rat  0   *Thioredoxins.
Txn2 protein, mouse  0   *Thioredoxins.
trx2 protein, S pombe  0   *Thioredoxins *Schizosaccharomyces pombe Proteins.
TRX2 protein, S cerevisiae  0   *Thioredoxins *Saccharomyces cerevisiae Proteins.
Trx-2 protein, Drosophila  0   *Thioredoxins *Drosophila Proteins.
Txn1 protein, mouse  0   *Thioredoxins. Endocrinology 2004 Dec;145(12):5485-92
AW 464  0   *Cyclohexanones *Benzothiazoles Thioredoxins/antagonists & inhibitors. Clin Cancer Res 2006 Sep 15;12(18):5384-94
AJM 290  0   *Indoles *Sulfones Thioredoxins/antagonists & inhibitors. Clin Cancer Res 2006 Sep 15;12(18):5384-94
YbbN protein, E coli  EC 1.8.-   *Molecular Chaperones *Escherichia coli Proteins *Oxidoreductases Acting on Sulfur Group Donors Thioredoxins. Biochem Biophys Res Commun 2006 May 12;343(3):780-6
Sep15 protein, Drosophila  0   *Drosophila Proteins *Selenoproteins Thioredoxins. J Biol Chem 2006 Feb 10;281(6):3536-43
TRX-1 protein, C elegans  0   *Thioredoxins *Caenorhabditis elegans Proteins Nerve Tissue Proteins. FEBS Lett 2006 Jan 23;580(2):484-90
TXNL4B protein, human  0   *Nuclear Proteins *Cell Cycle Proteins Thioredoxins. Biochemistry 2005 Sep 13;44(36):11997-2008
Txnl1 protein, mouse  0   *Thioredoxins.
TXNL1 protein, human  0   *Thioredoxins.
Txnl1 protein, rat  0   *Thioredoxins.
AtTDX protein, Arabidopsis  0   *Thioredoxins *Arabidopsis Proteins.
thioredoxin-binding protein-2, rat  0   *Carrier Proteins Thioredoxins. Lab Invest 2005 Jun;85(6):798-807
SSP411 protein, rat  0   *Thioredoxins. J Androl 2004 Jul-Aug;25(4):479-93
Txn1 protein, rat  0   *Thioredoxins. Neurosci Lett 2004 Nov 11;370(2-3):224-9
TXN protein, human  0   *Thioredoxins.
trxC protein, E coli  0   *Thioredoxins *Escherichia coli Proteins.
deadhead protein, Drosophila  0   *Membrane Proteins *Thioredoxins *Drosophila Proteins Nuclear Proteins.
Txndc2 protein, mouse  0   *Membrane Proteins *Thioredoxins.
TXNDC8 protein, human  0   *Thioredoxins Biological Markers. J Biol Chem 2004 Aug 13;279(33):34971-82
NXNL1 protein, human  0   *Thioredoxins. Nat Genet 2004 Jul;36(7):755-9
TrxT protein, Drosophila  0   *Thioredoxins *Drosophila Proteins Nuclear Proteins. Chromosoma 2003 Oct;112(3):133-43
TXNIP protein, human  0   *Carrier Proteins Thioredoxins.
PC-TRP protein, mouse  0   *Thioredoxins. Eur J Immunol 2004 Jan;34(1):137-46
TXNDC17 protein, human  0   *Thioredoxins. J Biol Chem 2004 Jan 30;279(5):3142-50
SPTRX-2 protein, rat  0   *Thioredoxins *Seminal Plasma Proteins Autoantigens. J Biol Chem 2003 Nov 7;278(45):44874-85
SPTRX-2 protein, mouse  0   *Thioredoxins *Seminal Plasma Proteins Autoantigens. J Biol Chem 2003 Nov 7;278(45):44874-85
TMX2 protein, human  0   *Membrane Proteins *Thioredoxins. Biochem Genet 2003 Apr;41(3-4):99-106
TXN2 protein, human  0   *Thioredoxins *Mitochondrial Proteins. J Biol Chem 2002 Sep 6;277(36):33249-57
TXNDC3 protein, human  0   *Thioredoxins. Genes Cells 2001 Dec;6(12):1077-90
DPY-11 protein, C elegans  0   *Membrane Proteins *Caenorhabditis elegans Proteins Thioredoxins. Development 2002 Mar;129(5):1185-94
Txnip protein, mouse  0   *Carrier Proteins *Thioredoxins. Nat Genet 2002 Jan;30(1):110-6
TXNDC2 protein, human  0   *Membrane Proteins *Thioredoxins. J Biol Chem 2001 Aug 24;276(34):31567-74
Trx80 protein, human  0   *Peptide Fragments *Thioredoxins. Blood 2001 May 15;97(10):3184-90
TMX1 protein, human  0   *Membrane Proteins *Thioredoxins. J Biol Chem 2001 Mar 30;276(13):10032-8
GLRX3 protein, human  0   *Carrier Proteins Thioredoxins. J Biol Chem 2000 Jan 21;275(3):1902-9; J Biol Chem 2003 Apr 11;278(15):13133-42
tryparedoxin  0   *Thioredoxins Protozoan Proteins. FEBS Lett 1998 Jul 24;431(3):381-5
NrdH protein, E Coli  0   *Thioredoxins *Escherichia coli Proteins. J Biol Chem 1997 Jul 18;272(29):18044-50
nucleoredoxin  0   *Nuclear Proteins *Oxidoreductases Thioredoxins. Genomics 1997 Feb 1;39(3):331-9
S protein, Phalaris  0   *Plant Proteins *Thioredoxins. Plant J 1996 Sep;10(3):505-13
thioredoxin C3 protein, Corynebacterium nephridii  0   *Bacterial Proteins *Thioredoxins. Biochim Biophys Acta 1996 Jun 3; 1307(1):13-6
thioredoxin-thioredoxin reductase hybrid protein, Mycobacterium leprae  0   *Bacterial Proteins *Thioredoxins *Thioredoxin-Disulfide Reductase. J Biol Chem 1995 Oct 27;270(43):25604-6
TxlA protein, Synechococcus  0   *Bacterial Proteins *Thioredoxins Oxidoreductases. J Bacteriol 1995 Jun;177(11):3269-76
RPP13-1 protein, Oryza sativa  0   *Plant Proteins Thioredoxins. Planta 1995;195(3):456-63
TlpA protein, Bradyrhizobium  0   *Bacterial Proteins *Thioredoxins. EMBO J 1993 Sep;12(9):3373-83
thioredoxin Ch2 protein, Chlamydomonas reinhardtii  0   *Thioredoxins Chlamydomonas. Nucleic Acids Res 1992 Feb 11;20(3):617
adult T cell leukemia-derived factor  0   *Neoplasm Proteins *Cytokines Growth Substances Thioredoxins. J Immunol 1988;140(8):2614
yeast proteinase B inhibitor  0   *Glycoproteins Thioredoxins. Eur J Biochem 1979;101(2):325; Hoppe Seylers Z Physiol Chem 359(8):999;1978; J Biol Chem 1979;254(24):12555
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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