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Heparin Lyase

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Definition: An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 4.2.2.7.      Other names Lyase, Heparin; I, Heparinase; Eliminase, Heparin; Neutralase; Heparinase I; Heparinase; Heparin Eliminase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
acharan sulfate lyase 1  EC 4.2.2.-   *Heparin Lyase. Eur J Biochem 2001 May;268(9):2635-41
acharan sulfate lyase 2  EC 4.2.2.-   *Heparin Lyase. Eur J Biochem 2001 May;268(9):2635-41
CRM646 B  0   *Hydroxybenzoic Acids Heparin Lyase/antagonists & inhibitors. J Antibiot (Tokyo) 2000 Feb;53(2):211-4
CRM646 A  0   *Hydroxybenzoic Acids Heparin Lyase/antagonists & inhibitors. J Antibiot (Tokyo) 2000 Feb;53(2):211-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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