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Polymyxin B

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Definition: A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.     
Pharmacological Action Anti-Bacterial Agents 		Other names Sulfate, Polymyxin B; Polymyxin B Sulfate; AerosporinDrugs* : POLYMYCIN B SULFATE; POLY-RX; AEROSPORIN; POLYMYXIN B SULFATE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NAB741  0   *Polymyxin B. Antimicrob Agents Chemother. 2010 Aug;54(8):3341-6
sP-Bpy compound  0   Polymyxin B/*analogs & derivatives. J Phys Chem B 2006 Mar 9;110(9):4465-71
sP-B compound  0   Polymyxin B/*analogs & derivatives. J Phys Chem B 2006 Mar 9;110(9):4465-71
sP-Bw compound  0   Polymyxin B/*analogs & derivatives. J Phys Chem B 2006 Mar 9;110(9):4465-71
polysporin ointment  0   *Bacitracin *Gramicidin *Polymyxin B Drug Combinations Ointments. Infect Control Hosp Epidemiol 2000 Oct;21(10):653-5
diaminobutyryl-cyclo(diaminobutyryl-diaminobutyryl-phenylalanyl-leucyl-diaminobutyryl-diaminobutyryl-threonyl)  142563-39-1   Polymyxin B/*analogs & derivatives. J Antibiot (Tokyo) 1992 May;45(5):742-9
cyclo(diaminobutyryl-diaminobutyryl-phenylalanyl-leucyl-diaminobutyryl-diaminobutyryl-threonyl)  142563-40-4   Polymyxin B/*analogs & derivatives. J Antibiot (Tokyo) 1992 May;45(5):742-9
bacitracin, polymyxin B drug combination  118933-13-4   *Bacitracin *Polymyxin B. Postgrad Med J 1990;66(789):858POLYSPORIN; LANABIOTIC; OCUMYCIN; BACITRACIN ZINC AND POLYMYXIN B SULFATE; BACITRACIN ZINC-POLYMYXIN B SULFATE
polymyxin B sulfate, neomycin sulfate, sulfonamide, and hydrocortisone drug combination  143305-95-7   *Hydrocortisone *Neomycin *Polymyxin B *Sulfonamides Drug Combinations. Arch Otolaryngol Head Neck Surg 1991;117(5):537
Septomixine  0   Neomycin Polymyxin B Tyrothricin. Aust Dent J 1990;35(6):551
auricularum  0   *Nystatin *Oxytetracycline *Polymyxin B Dexamethasone/*analogs & derivatives Drug Combinations. Ann Otolaryngol Chir Cervicofac 1988;105(8):635
Polytrim eyedrops  53320-96-0   *Polymyxin B *Trimethoprim Drug Combinations. Drug Ther Bull 1988;26(11):43TRIMETHOPRIM SULFATE AND POLYMYXIN B SULFATE; POLYTRIM
Uniroid  123354-95-0   *Dibucaine *Hydrocortisone *Neomycin *Polymyxin B Drug Combinations. Curr Med Res Opin 1988;11(1):34
polyspectran OS  117733-87-6   *Bacitracin *Hydrocortisone *Neomycin *Polymyxin B Drug Combinations. Klin Monatsbl Augenheilkd 1987;190(1):28BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE; NEOMYCIN AND POLYMYXIN B SULFATES, BACITRACIN ZINC AND HYDROCORTISONE; NEOMYCIN & POLYMYXIN B SULFATES & BACITRACIN ZINC & HYDROCORTISONE; ZINC BACITRACIN,NEOMYCIN SULFATE,POLYMYXIN B SULFATE & HYDROCORTISONE
Maxitrol  78666-15-6   *Fluprednisolone *Neomycin *Polymyxin B Drug Combinations. Klin Monatsbl Augenheilkd 1986;189(1):46MAXITROL
polymyxin B nonapeptide  86408-36-8 Polymyxin B1, 1-de(N2-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoic acid)  Polymyxin B/*analogs & derivatives.
Pharma Action Anti-Infective Agents ; Photosensitizing Agents 		Antimicrob Agents Chemother 1983;24(1):107
hydrocortisone, neomycin, polymyxin B drug combination  0   *Hydrocortisone *Neomycin *Polymyxin B Drug Combinations.
Pharma Action Anti-Bacterial Agents 		J R Coll Gen Pract 1981;31(226):291OTOCORT; PEDIOTIC; CORTISPORIN; NEOMYCIN AND POLYMYXIN B SULFATES AND HYDROCORTISONE; OTICAIR; NEOMYCIN SULFATE, POLYMYXIN B SULFATE & HYDROCORTISONE; NEOMYCIN SULFATE-POLYMYXIN B SULFATE-HYDROCORTISONE; OTOBIONE
pelargonoyl-cyclic decapeptide polymyxin B(1)  76721-93-2 Pelargonoylcyclic decapeptide  Polymyxin B/*analogs & derivatives. Pharmazie 1980;35(9):540
Panotile  99401-18-0 Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11beta)-, mixt. with alkylbenzyldimethylammonium chlorides, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, neomycin sulfate (salt) and polymyxin B sulfate (salt)  *Benzalkonium Compounds *Lidocaine *Neomycin *Polymyxin B Drug Combinations Fludrocortisone/*analogs & derivatives. Rev Laryngol Otol Rhinol 99(11-12):765;1978
dexamethasone, neomycin, polymyxin B drug combination  0   *Dexamethasone *Neomycin *Polymyxin B Drug Combinations.
Pharma Action Anti-Bacterial Agents 		J Fran Otorhinolaryngol 28(7):549;1977DEXASPORIN; DEXACIDIN; NEOMYCIN AND POLYMYXIN B SULFATES AND DEXAMETHASONE
pulpomixine  78515-94-3 Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)-, mixt. with O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,3-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2  Framycetin Polymyxin B. Czas Stomatol 27(7):752;1974
dexamethasone isonicotinate, oxytetracycline, polymyxin B, tramazoline drug combination  0   *Dexamethasone Isonicotinate *Imidazoles *Oxytetracycline *Polymyxin B Drug Combinations. Med Welt 24(27/28):1145;1973
bacitracin zinc, neomycin sulfate, polymyxin B, drug combination  8057-37-2 Bacitracin zinc, mixture with neomycin sulfate (salt) & polymyxin B sulfate (salt)  *Bacitracin *Neomycin *Polymyxin B Drug Combinations.
Pharma Action Anti-Infective Agents, Local ; Anti-Bacterial Agents 		Arch Dermatol 1979;115(11):1311; Chemotherapy 1980;26(1):64; Lancet 2(8030):196;1977; Laryngoscope 87(9):1533;1977; South Med J 65(9):1083;1972; Ther Gegenwart 115(5):879;1976NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC; BACITRACIN ZINC-NEOMYCIN SULFATE-POLYMYXIN B SULFATE; BACITRACIN-NEOMYCIN-POLYMYXIN; NEOSPORIN; NEO-POLYCIN; MYCITRACIN; LANABIOTIC

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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