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Hydroxysteroid Dehydrogenases

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Definition: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.     
Examples 11-beta-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; 17-Hydroxysteroid Dehydrogenases; 20-Hydroxysteroid Dehydrogenases 		Other names Dehydrogenases, Hydroxysteroid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
HSDL2 protein, human  EC 1.1.-   *Hydroxysteroid Dehydrogenases. Biochem Genet 2003 Jun;41(5-6):165-74
HSDL1 protein, human  EC 1.1.-   *Hydroxysteroid Dehydrogenases. Mol Biol Rep 2001;28(4):185-91
Hadh2 protein, mouse  EC 1.1.1.35   *3-Hydroxyacyl CoA Dehydrogenases Hydroxysteroid Dehydrogenases. Brain Res Mol Brain Res 2002 Feb 28;99(1):46-53
Rdh1 protein, mouse  EC 1.1.-   *Hydroxysteroid Dehydrogenases. J Biol Chem 2001 Nov 23;276(47):44083-90
AKR1C2 protein, human  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Biochemistry 2001 Aug 28;40(34):10161-8
3alpha-hydroxysteroid dehydrogenase-carbonyl reductase  EC 1.1.-   *Hydroxysteroid Dehydrogenases. J Biol Chem 2001 Mar 30;276(13):9961-70
3-hydroxysteroid dihydrodiol dehydrogenase  EC 1.-   *Hydroxysteroid Dehydrogenases. J Steroid Biochem Mol Biol 1999 Nov;71(1-2):29-39
HSD17B10 protein, human  EC 1.1.1.35   *3-Hydroxyacyl CoA Dehydrogenases Hydroxysteroid Dehydrogenases. Nature 1997 Oct 16;389(6652):689-95
3 alpha(17 beta)-hydroxysteroid dehydrogenase (NAD+)  EC 1.1.1.239   *Hydroxysteroid Dehydrogenases. J Biochem (Tokyo) 1991;109(5):770
dihydrocortisol 3alpha-oxidoreductase  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Steroids 1990;55(11):495
12 beta-hydroxysteroid dehydrogenase  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Biochim Biophys Acta 1988;962(3):362
3 beta,20 alpha-hydroxysteroid oxidoreductase  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Biochemistry 1982;21(19):4615
3(17)-hydroxysteroid dehydrogenase  EC 1.1.1.209   *Hydroxysteroid Dehydrogenases. J Biol Chem 1982;257(16):9444
7 beta-hydroxysteroid dehydrogenase  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Biochim Biophys Acta 1981;665(2):262
18-hydroxycorticosterone dehydrogenase  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Nouv Presse Med 1981;10(2):513
7 alpha-hydroxysteroid dehydrogenase  EC 1.1.1.159   *Hydroxysteroid Dehydrogenases. J Lipid Res 1980;21(3):381
ecdysone dehydrogenase-isomerase  EC 1.1.1.-   *Hydroxysteroid Dehydrogenases. Lipids 9(12):971;1974
21-oxo-20-hydroxysteroid reductase  EC 1.1.1.- 17 beta-aldol reductase  *Hydroxysteroid Dehydrogenases. J Biol Chem 253:2126;1978
cholestanetetraol 26-dehydrogenase  EC 1.1.1.161   *Hydroxysteroid Dehydrogenases. Biochim Biophys Acta 185(1):1;1969
12 alpha-hydroxysteroid dehydrogenase  EC 1.1.1.176   *Hydroxysteroid Dehydrogenases. J Lipid Res 20(2):234;1979; Scand J Gastroenterol 9(6):555;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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