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20-Hydroxysteroid Dehydrogenases

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Definition: A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53).  do not confuse with 20-BETA-HYDROXYSTEROID DEHYDROGENASE (see CORTISONE REDUCTASE)   
Examples 20-alpha-Hydroxysteroid Dehydrogenase; Cortisone Reductase 		Other names Hydroxysteroid Dehydrogenases, 20; Dehydrogenases, 20-Hydroxysteroid; Dehydrogenases, 20 Hydroxysteroid; 20 Hydroxysteroid Dehydrogenases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3 alpha-beta, 20 beta-hydroxysteroid dehydrogenase  EC 1.1.1.-   *20-Hydroxysteroid Dehydrogenases. Biochem J 1998 Sep 15;334( Pt 3):553-7
progesterone 20-keto-reductase  EC 1.1.1.-   *Cytochrome P-450 Enzyme System *20-Hydroxysteroid Dehydrogenases. Biochem Biophys Res Commun 1992 Apr 15;184(1):338-46
1-(3-hydroxyandrostan-17-yl)-2-propen-1-one  0   *Androstanols 20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Biochem J 1986 Dec 15;240(3):717-23
16-methylene estradiol  7627-87-4 Estra-1,3,5(10)-triene-3,17-diol, 16-methylene-, (17beta)  Estradiol/*analogs & derivatives 20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Biol Chem 1983;258(19):11500
16-methylene estrone  10506-73-7 Estra-1,3,5(10)-trien-17-one, 3-hydroxy-16-methylene  Estrone/*analogs & derivatives 20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Biol Chem 1983;258(19):11500

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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