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Phosphorylases

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Definition: A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as glucose polymers, by phosphorolysis in animals (GLYCOGEN PHOSPHORYLASE) and in plants (STARCH PHOSPHORYLASE).  GEN or unspecified; prefer specifics   
Examples Glycogen Phosphorylase; Phosphorylase a; Phosphorylase b; Starch Phosphorylase 		Other names Glucan Phosphorylase; alpha-Glucan Phosphorylases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
galacto-N-biose-lacto-N-biose I phosphorylase, Bifidobacterium longum  EC 2.4.1.-   *Phosphorylases. J Biol Chem 2009 Mar 13;284(11):7273-83
glucopyranosylidene-spiro-hydantoin  0   *Hydantoins *Spiro Compounds Phosphorylases/antagonists & inhibitors. Bioorg Med Chem Lett 1999 May 17;9(10):1385-90
4-deoxymaltohexaose  0   *Oligosaccharides Phosphorylases/antagonists & inhibitors. Biochem J 1999 Mar 1;338( Pt 2):251-6
4-deoxymaltopentaose  0   *Oligosaccharides Phosphorylases/antagonists & inhibitors. Biochem J 1999 Mar 1;338( Pt 2):251-6
CP 91149  0   *Amides *Indoles Phosphorylases/antagonists & inhibitors. Proc Natl Acad Sci U S A 1998 Feb 17;95(4):1776-81
Bay W1807  0   *Quinolinic Acids Phosphorylases/antagonists & inhibitors. Structure 1997 Nov 15;5(11):1413-25
glycogen phosphorylase 2 protein, Dictyostelium discoideum  EC 2.4.1.-   *Phosphorylases DNA-Binding Proteins Isoenzymes. Biochim Biophys Acta 1997 Mar 20;1351(1-2):111-25; Dev Genet. 1993;14(4):313-22; J Biol Chem. 1992 Feb 5;267(4):2294-302
N-acetylglucopyranosylamine  6983-36-4   Glucosamine/*analogs & derivatives Phosphorylases/antagonists & inhibitors. Protein Sci 1995 Dec;4(12):2469-77
225 kDa protein, Babesia bovis  0   *Protozoan Proteins Antigens, Protozoan Phosphorylases. Mol Biochem Parasitol 1992 Jun;52(2):263-9
3'-chloromethotrexate  5472-96-8   Methotrexate/*analogs & derivatives Phosphorylases/antagonists & inhibitors. Bioorg Khim 1988;14(9):1162
gluconohydroximo-1,5-lactone-N-phenylurethane  102579-56-6   *Carbamates *Gluconates beta-Glucosidase/antagonists & inhibitors Phosphorylases/antagonists & inhibitors. Biochemistry 1988;27(18):6733

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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