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Fibroblast Growth Factors

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Definition: A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.     
See Also Receptors, Fibroblast Growth Factor
Examples Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblast Growth Factor 3; Fibroblast Growth Factor 4; Fibroblast Growth Factor 5; Fibroblast Growth Factor 6; Fibroblast Growth Factor 7; Fibroblast Growth Factor 8; Fibroblast Growth Factor 9; Fibroblast Growth Factor 10 		Other names Growth Factors, Fibroblast; Growth Factor, Fibroblast; Fibroblast Growth Regulatory Factor; Fibroblast Growth Factor; DNA Synthesis Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Fgf4 protein, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. Dev Biol 2009 Aug 1;332(1):177-85
FGF19 protein, rat  0   *Fibroblast Growth Factors. J Biol Chem 2009 Apr 10;284(15):10023-33
eFGF protein, Xenopus  0   *Fibroblast Growth Factors *Xenopus Proteins. EMBO J 1994 Oct 3;13(19):4469-81
NUDT6 protein, rat  0   *Fibroblast Growth Factors. Proc Natl Acad Sci U S A 1997 May 13;94(10):4943-7
Fgf8 protein, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. BMC Dev Biol 2007;7:5
Fgf16 protein, zebrafish  0   *Fibroblast Growth Factors. Biochem Biophys Res Commun 2006 Aug 18;347(1):340-6
FGF16 protein, human  0   *Fibroblast Growth Factors. Biochem Biophys Res Commun 1998 Feb 4;243(1):148-52
Fgf19 protein, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins Nerve Tissue Proteins. Dev Biol 2005 Dec 1;288(1):259-75
fibroblast growth factor 25, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. Int J Mol Med 2005 Oct;16(4):767-70
fibroblast growth factor 22, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. Int J Mol Med 2005 Oct;16(4):767-70
Fgf23 protein, rat  0   *Fibroblast Growth Factors. Int J Mol Med 2005 Aug;16(2):355-8
fibroblast growth factor 11, rat  0   *Fibroblast Growth Factors. Oncol Rep 2005 Jul;14(1):291-4
fibroblast growth factor 11, mouse  0   *Fibroblast Growth Factors. Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9850-7
fibroblast growth factor 20, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. Oncol Rep 2005 Jul;14(1):287-90
SPRY4 protein, human  0   *Nerve Tissue Proteins *Intracellular Signaling Peptides and Proteins Fibroblast Growth Factors.
Spry4 protein, mouse  0   *Nerve Tissue Proteins Fibroblast Growth Factors.
Fgf20 protein, rat  0   *Fibroblast Growth Factors.
Fgf20 protein, mouse  0   *Fibroblast Growth Factors.
FHF2B protein, rat  0   *Fibroblast Growth Factors. J Neurosci 2004 Jul 28;24(30):6765-75
FGF12 protein, human  0   *Fibroblast Growth Factors.
SPRY2 protein, human  0   *Intracellular Signaling Peptides and Proteins Fibroblast Growth Factors.
Fgf17 protein, mouse  0   *Fibroblast Growth Factors.
fibroblast growth factor 17, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins.
FGF17 protein, human  0   *Fibroblast Growth Factors.
Fgf16 protein, mouse  0   *Fibroblast Growth Factors.
fibroblast growth factor 18, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. Development 2003 Oct;130(19):4639-54
fibroblast growth factor 24, zebrafish  0   *Fibroblast Growth Factors *Zebrafish Proteins. Development 2003 Oct;130(19):4639-54
fibroblast growth factor 22, mouse  0   *Fibroblast Growth Factors. Exp Cell Res 2003 Jul 15;287(2):228-36
human acidic fibroblast growth factor (99-108) amide  0   *Fibroblast Growth Factors *Peptide Fragments. J Med Chem 2003 Jun 5;46(12):2325-33
spry4 protein, zebrafish  0   *Nerve Tissue Proteins *Zebrafish Proteins Fibroblast Growth Factors/antagonists & inhibitors. Development 2001 Jun;128(12):2175-86
fibroblast growth factor 23  0   *Fibroblast Growth Factors. Nat Genet 2000 Nov;26(3):345-8
FGF20 protein, human  0   *Fibroblast Growth Factors. Biochem Biophys Res Commun. 2000 Oct 22;277(2):355-60
fibroblast growth factor 21  0   *Fibroblast Growth Factors. Biochim Biophys Acta 2000 Jun 21;1492(1):203-6
Spry2 protein, rat  0   *Nerve Tissue Proteins Fibroblast Growth Factors/antagonists & inhibitors. Mol Cell Neurosci 2000 Jan;15(1):22-35
Let-756 protein, C elegans  0   *Fibroblast Growth Factors *Caenorhabditis elegans Proteins. Oncogene 1999 Nov 18;18(48):6741-7
fibroblast growth factor 20, Xenopus  0   *Fibroblast Growth Factors *Xenopus Proteins. Biochem Biophys Res Commun 1999 Aug 11;261(3):756-5
Spry2 protein, mouse  0   *Membrane Proteins Fibroblast Growth Factors/antagonists & inhibitors.
FGF19 protein, human  0   *Fibroblast Growth Factors. Biochim Biophys Acta 1999 Jan 18;1444(1):148-51
trafermin  131094-16-1   *Fibroblast Growth Factors *Peptide Fragments. Clin Pharmacol Ther 1998 Aug;64(2):235
fibroblast growth factor 18  0   *Fibroblast Growth Factors. J Biol Chem 1998 Jul 17;273(29):18161-4
fibroblast growth factor 14  0   *Fibroblast Growth Factors. Biochim Biophys Acta 1998 May 29;1398(1):38-41
soc-2 protein, C elegans  0   *Fibroblast Growth Factors *Repressor Proteins *Caenorhabditis elegans Proteins. Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6903-8
Fgf17 protein, rat  0   *Fibroblast Growth Factors. Biochem Biophys Res Commun 1998 Mar 6;244(1):187-91
Fgf16 protein, rat  0   *Fibroblast Growth Factors. Biochem Biophys Res Commun 1998 Feb 4;243(1):148-52
fibroblast growth factor 15, mouse  0   *Fibroblast Growth Factors. Development 1997 Sep;124(17):3221-32
fibroblast growth factor 13  0   *Fibroblast Growth Factors. Mech Dev 1997 Jun;64(1-2):31-9
Fgf12 protein, mouse  0   *Fibroblast Growth Factors. Mech Dev 1997 Jun;64(1-2):31-9
branchless protein, Drosophila  0   *Fibroblast Growth Factors *Drosophila Proteins. Science 1996 Dec 20;274(5295):2011
Fgfr3 protein, rat  144590-76-1   *Receptor, Fibroblast Growth Factor, Type 3 Fibroblast Growth Factors. Oncogene 1991;1991;6(6):1089
protein CS23  0   *Fibroblast Growth Factors Recombinant Proteins. Jpn J Pharmacol 1990;53(2):221
keratinocyte growth factor receptor  EC 2.7.1.-   *Receptor, Fibroblast Growth Factor, Type 2 Fibroblast Growth Factors Keratinocytes. J Biol Chem 1990;265(22):12767
fibroblast growth factor (1-10)  96927-63-8   *Fibroblast Growth Factors *Peptide Fragments Iodine Radioisotopes. Biochem Biophys Res Commun 1987;145(2):775
fibroblast pneumonocyte factor  0   *Fibroblast Growth Factors. J Appl Physiol 1984;57(5):1577
eye-derived growth factor  0   Fibroblast Growth Factors Eye/physiology Growth Substances. Exp Cell Res 1983;149(1):69

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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