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Cholic Acids

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Definition: The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.  cholic acid glycine conjugate   
Pharmacological Action Gastrointestinal Agents
Examples Cholic Acid; Dehydrocholic Acid; Deoxycholic Acid; Glycocholic Acid; Lithocholic Acid; Taurocholic Acid 		Other names Cholalic Acids; Acids, Cholic; Acids, Cholalic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5 beta-3-ketopetromyzonol sulfate  0   *Cholic Acids. Steroids. 2011 Feb;76(3):291-300
(22E)-3alpha,6alpha,7alpha,12alpha-tetrahydroxy-5beta-chol-22-en-24-oic acid  0   *Cholic Acids. Chem Pharm Bull (Tokyo). 2010;58(8):1103-6
3,12,16-trihydroxycholan-24-oic acid  0   *Cholic Acids. Steroids 2010 Jul;75(7):506-12
6alpha-ethyl-23(S)-methylcholic acid  0   *Cholic Acids. Cell Metab. 2009 Sep;10(3):167-77
3,12-dihydroxy-7-ketocholanoic acid  0   *Cholic Acids. Colloids Surf B Biointerfaces 2009 Nov 1;74(1):84-90
12-monoketocholic acid  0   *Cholic Acids. Eur J Drug Metab Pharmacokinet. 2009 Apr-Jun;34(2):73-8
3-dimethoxy-12alpha-hydroxycholanic acid  0   *Cholic Acids. Arch Pharm Res. 2009 Jun;32(6):857-62
cholic acid-verticinone ester  0   *Cevanes *Cholic Acids. Acta Pharmacol Sin. 2009 May;30(5):559-66
tauroansocholic acid  0   *Cholic Acids. Chem Pharm Bull (Tokyo). 2009 May;57(5):528-31
3alpha,7alpha,9alpha-trihydroxy-5beta-cholan-24-oic acid N-(2-sulfoethyl) amide  0   *Cholic Acids. Chem Pharm Bull (Tokyo). 2009 May;57(5):528-31
N-fluoresceinyl-3,7,12-trihydroxycholan-24-amide  0   *Cholic Acids *Fluoresceins. Photochem Photobiol Sci 2008 Jul;7(7):860-6
3alpha,12alpha-dihydroxy-5beta-cholan-24-amine  0   *Cholic Acids. Langmuir 2008 Jun 17;24(12):6060-6
lucidenic acid C  0   *Cholic Acids. Mol Nutr Food Res 2007 Dec;51(12):1472-7
lucidenic acid B  0   *Cholic Acids. Mol Nutr Food Res 2007 Dec;51(12):1472-7
Syn3 compound  0   *Cholic Acids *Disaccharides. Cytokine Growth Factor Rev 2007 Oct-Dec;18(5-6):389-94
methyl allocholate  0   *Cholic Acids. Chem Commun (Camb). 2006 Jun 14;(22):2335-7
3beta-sulfooxy-12alpha-hydroxy-5beta-cholanoic acid  0   *Cholic Acids. J Chromatogr B Analyt Technol Biomed Life Sci 2007 Feb 1;846(1-2):69-77
3,7,12-triacetoxycholanic acid  0   *Cholic Acids. Nat Prod Res 2006 Jul 10;20(8):748-53
3beta,7beta-dihydroxy-5-cholen-24-oic acid  0   *Cholic Acids. Chem Phys Lipids 2006 Apr;140(1-2):48-54
(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid  0   *Cholic Acids Estrone/*analogs & derivatives. J Pharmacol Exp Ther. 2005 Jul;314(1):191-200
N-methyl-5beta glycocholanic acid  0   *Cholic Acids. J Steroid Biochem Mol Biol 2005 Mar;94(4):311-8
petromyzonol sulfate  0   *Cholic Acids. Bioessays 2005 Feb;27(2):222-8
3-oxo-chol-1,4,22-trien-24-oic acid  0   *Cholic Acids. J Nat Prod 2004 Dec;67(12):2130-2
11-acetyl-3-oxo-chol-4-en-24-oic acid  0   *Cholic Acids. J Nat Prod 2004 Dec;67(12):2130-2
3-oxo-12alpha-hydroxy-5beta-cholan-24-oic acid  0   *Cholic Acids. Steroids 2004 Jun;69(6);379-88
3,7,14-trihydroxycholanoic acid  0   *Cholic Acids. Chem Pharm Bull (Tokyo) 2004 Mar;52(3);371-4
lucidenic acid A  0   *Cholic Acids. Yao Xue Xue Bao 2001 Aug;36(8):595-8
3-keto allocholic acid  0   *Cholic Acids. Steroids 2003 Mar;68(3):297-304
methyl 3-carbethoxy-12-acetoxy-6-oxochol-7-en-24-oate  0   *Cholic Acids. Steroids 2003 Mar;68(3):253-6
tetrahydroxy-5-cholan-24-oic acid  0   *Cholic Acids. J Lipid Res 2003 Mar;44(3):494-502
PPI 368  0   *Cholic Acids *Oligopeptides. Amyloid 2001 Dec;8(4):231-41
aramchol  0   *Cholic Acids. Lipids 2001 Oct;36(10):1135-40
7alpha,12alpha,24-trihydroxy-5alpha-cholan-3-one 24-sulfate  0   *Cholic Acids. Science 2002 Apr 5;296(5565):138-41
3,6-dihydroxy-5-cholanoic acid-N-methyl-N-methoxy-24-amide  0   *Cholic Acids. Steroids 2001 Sep;66(9):673-81
N,N-bis(3-gluconamidopropyl)deoxycholamide  0   *Cholic Acids. Biochemistry 2001 Sep 18;40(37):11022-9
bishomocholic acid  0   *Cholic Acids. J Am Chem Soc 2001 May 16;123(19):4386-92
cholenic acid dimethylamide  0   *Cholic Acids. J Med Chem 2001 Mar 15;44(6):886-97
3-oxo-6-hydroxycholanoic acid methyl ester  0   *Cholic Acids. Steroids 2000 Aug;65(8):423-7
N,N-dimethyl-3-hydroxy-5-cholenamide  0   *Cholic Acids. Steroids 2000 Aug;65(8):423-7
N(2),N(2)-dimethylamino-N(1)-2-ethylcholeamide  0   *Cholic Acids. Bioconjug Chem 2000 May-Jun;11(3):397-400
cholyl-coenzyme A  0   *Acyl Coenzyme A *Cholic Acids. Anal Biochem 1999 Jan 1;266(1):125-32
cholyl-adenylate  0   *Cholic Acids Adenosine Monophosphate/*analogs & derivatives. Anal Biochem 1999 Jan 1;266(1):125-32
7,12-dihydroxy-4',4'-dimethylspiro(5-cholan-24-oic-3,2'-oxazolidin)-3'-yloxy acid  0   *Cholic Acids *Cyclic N-Oxides. Chem Phys Lipids 1997 Aug 29;88(2):97-106
cholyl-2-(4-N-nitrobenzoxadiazolyl)aminobutyl-glycine  0   *Cholic Acids Glycine/*analogs & derivatives. Am J Physiol 1997 Jun;272(6 Pt 1):G1416-24
6-hydroxy-3-(N(1)-sperminyl)-5alpha-cholan-24-oic acid  0   Cholic Acids Spermine/analogs & derivatives. Steroids 1996 Oct;61(10):565-71
methyl 3-(aminoethylamino)-6-hydroxy-5alpha-cholan-24-oate  0   Cholic Acids Ethylenediamines. Steroids 1996 Oct;61(10):565-71
3,7,12-trihydroxy-24-cholanic acid methyl ester  0   Cholic Acids. Biosci Biotechnol Biochem 1995 Oct;59(10):1966-7
3,7,12,19-tetrahydroxycholanoic acid  0   *Cholic Acids. Chem Pharm Bull (Tokyo) 1995 Sep;43(9):1551-7
cholyl-nitrobenzoxadiazolyl-lysine  0   *Cholic Acids Lysine/*analogs & derivatives. Hepatology 1995 Aug;22(2):637-47
6-methyl-7-epicholic acid  0   *Cholic Acids. J Lipid Res 1994 Dec;35(12):2268-79
N-(1,3,7,12-tetrahydroxycholan-24-oyl)-2-aminopropionic acid  145644-16-2   *Cholic Acids. Chem Pharm Bull (Tokyo) 1992 Jul;40(7):1835-8
cholyl-lysylfluorescein  0   *Cholic Acids *Fluoresceins. Biochim Biophys Acta 1991;1115(2):151
norursocholic acid  139265-35-3 24-Norcholan-23-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7beta,12alpha)  *Cholic Acids *Norsteroids. Am J Physiol 1991;261(6 Pt 1):G1057
N-carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-(N'-(2-((3,7,12-trihydroxycholan-24-oyl)amino)ethyl)(thioureido)phenyl)alanine  132910-41-9   *Cholic Acids Edetic Acid/*analogs & derivatives. Bioconjug Chem 1991;2(2):117
3-hydroxy-7-(hydroxyimino)cholanic acid  131204-64-3   *Cholic Acids Bile Acids and Salts. J Pharmacobiodynam 1990;13(9):558
7,12-dihydroxy-3-(2-(glucopyranosyl)acetyl)cholan-24-oic acid  131528-41-1   *Cholic Acids. Steroids 1990;55(7):303
glyco-3,12-dihydroxy-5-cholen-24-oic acid  0   *Cholic Acids. Chem Pharm Bull (Tokyo) 1989;37(8):2147
cholylsarcosine  93790-70-6 Glycine, N-methyl-N-((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)  *Cholic Acids Sarcosine/*analogs & derivatives. Gastroenterology 1990;98(1):163
3,4,7-trihydroxycholanoic acid  117590-81-5   *Cholic Acids. J Lipid Res 1989;30(6):847
3-iodocholic acid  85121-73-9   *Cholic Acids Drug Carriers. Ann NY Acad Sci 1987;507:315
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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