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Lithocholic Acid

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Definition: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.  a bile acid; /biosyn /physiol permitted   
Pharmacological Action Detergents
Examples Taurolithocholic Acid 		Other names Lithocholate; Acid, Lithocholic; Acid, Isolithocholic; Isolithocholic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AL-10 compound  0   Lithocholic Acid/*analogs & derivatives Sialyltransferases/antagonists & inhibitors. J Cell Physiol. 2010 May;223(2):492-9
3-ketocholanoic acid  0   Lithocholic Acid/*analogs & derivatives. Drug Metab Dispos. 2009 Sep;37(9):1938-47
15-hydroxylithocholic acid  0   Lithocholic Acid/*analogs & derivatives. J Lipid Res 2007 Dec;48(12):2682-92
folate-heparin-lithocholate  0   Heparin/*analogs & derivatives Lithocholic Acid/*analogs & derivatives. Pharm Res 2007 Apr;24(4):705-14
heparin-lithocholate  0   Heparin/*analogs & derivatives Lithocholic Acid/*analogs & derivatives. Pharm Res 2007 Apr;24(4):705-14
lithocholic acid acetate  0   Lithocholic Acid/*analogs & derivatives Receptors, Calcitriol/agonists. J Lipid Res 2005 Jan;46(1):46-57
lithocholylcholine  0   Lithocholic Acid/*analogs & derivatives Receptors, Muscarinic/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Oct;303(1):29-35
3-ketolithocholic acid  0   Lithocholic Acid/*analogs & derivatives. Science 2002 May 17;296(5571):1313-6
lithocholamide  0   Lithocholic Acid/*analogs & derivatives. Enantiomer 2000;5(1):95-104
3-O-(4-nitrophenylphosphate)lithocholic acid  0   *Phosphoric Acid Esters Lithocholic Acid/*analogs & derivatives. Appl Biochem Biotechnol 1998 Oct;75(1):33-44
lithocholyl-lysyl-fluorescein  0   *Fluoresceins Lithocholic Acid/*analogs & derivatives Lysine/*analogs & derivatives. Biochim Biophys Acta 1997 Oct 20;1336(3):485-96
3-glucosido-lithocholic acid  0   *Glucosides Lithocholic Acid/*analogs & derivatives. J Biol Chem 1997 Apr 25;272(17):11261-7
7-oxolithocholic acid 3-sulfate  0   Lithocholic Acid/*analogs & derivatives. Hepatology 1994 Sep;20(3):663-71
4-azidophenacyl lithocholate  149021-83-0   *Azides Lithocholic Acid/*analogs & derivatives. Biochim Biophys Acta 1993 Jun 18;1149(1):135-44
3-aminocholan-24-oic acid  0   Lithocholic Acid/*analogs & derivatives. Steroids 1991 Jul;56(7):395-8
BRL 39924A  131221-62-0   Lithocholic Acid/*analogs & derivatives. Biochem Pharmacol 1990;40(9):2029
N-carbobenzoxy-N-lithocholyl-epsilon-lysine  104211-96-3   Lithocholic Acid/*analogs & derivatives Lysine/*analogs & derivatives. J Lipid Res 1986;27(8):905
24-norlithocholic acid  15238-52-5   Lithocholic Acid/*analogs & derivatives. J Lipid Res 1986;27(1):102
lithocholyl-N-hydroxysuccinimide  104211-94-1   *Succinimides Lithocholic Acid/*analogs & derivatives. J Steroid Biochem 1985;23(5A):573
3-hydroxy-6-cholen-24-oic acid  3664-87-7   Lithocholic Acid/*analogs & derivatives. J Biol Chem 1985;260(20):11011
3-oxochol-4-en-24-oic acid  1452-29-5   Lithocholic Acid/*analogs & derivatives. J Steroid Biochem 1985;22(6):817
3-oxocholan-24-oic acid  1553-56-6   Lithocholic Acid/*analogs & derivatives. J Steroid Biochem 1985;22(6):817
N-epsilon-lithocholyllysine  65236-49-9   Lithocholic Acid/*analogs & derivatives. J Lipid Res 1984;25(11):1263
3-hydroxy-7-methylcholanoic acid  96648-30-5 Cholan-24-oic acid, 3-hydroxy-7-methyl-, (3alpha,5beta)  Lithocholic Acid/*analogs & derivatives. J Lipid Res 1984;25(4):407
lithocholate 3-O-glucuronide  75239-91-7 beta-D-Glucopyranosiduronic acid, (3alpha,5beta)-23-carboxy-24-norcholan-3-yl, (SP-4-2)  *Glucuronates *Lithocholic Acid. J Clin Invest 1984;73(6):1507
3-dehydrolithocholylglycine  84573-10-4 Glycine, N-((5beta)-3,24-dioxocholan-24-yl)-, methyl ester  Lithocholic Acid/*analogs & derivatives. Steroids 1983;41(2):165
methyl lithocholate  1249-75-8   Lithocholic Acid/*analogs & derivatives. Biophys Chem 1982;16(4):317
12-ketolithocholic acid  5130-29-0   Lithocholic Acid/*analogs & derivatives. Biochim Biophys Acta 1981;114(2-3):137
3-hydroxy-7,12-diketocholanoic acid  517-33-9   Lithocholic Acid/*analogs & derivatives. Clin Chim Acta 1981;114(2-3):137
glycolithocholic acid  474-74-8   Lithocholic Acid/*analogs & derivatives. Anal Biochem 1980;105(1):170
7-ketolithocholic acid  4651-67-6 (3 alpha,5 beta)-3-hydroxy-7-oxocholan-24-oic acid  Lithocholic Acid/*analogs & derivatives.
Pharma Action Cholagogues and Choleretics 		Gastroenterol Jpn 14(5):417;1979
sulfolithocholic acid  34669-57-3   Lithocholic Acid/*analogs & derivatives. Cas Lek Ces 118(35):1078;1979; Gastroenterology 72:499;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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