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Arginase

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Definition: A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.     
See Also Hyperargininemia 		Other names Protein, Liver-Derived Inhibitory; Protein, Liver Immunoregulatory; Proliferation Inhibitor, Hepatic; Liver Derived Lymphocyte Proliferation Inhibiting ; Liver Derived Inhibitory Protein; Inhibitory Protein, Liver-Derived; Inhibitor, Hepatic Proliferation; Immunoregulatory Protein, Liver; Liver-Derived Lymphocyte Proliferation Inhibiting ; Liver-Derived Inhibitory Protein; Liver Immunoregulatory Protein; Hepatic Proliferation Inhibitor; Arginase A4; Arginase A1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-6-borono-2-(difluoromethyl)hexanoic acid  0   *Amino Acids *Boronic Acids Arginase/antagonists & inhibitors. J Med Chem 2011 Aug 11;54(15):5432-43
2-amino-6-borono-2-methylhexanoic acid  0   *Amino Acids *Boronic Acids Arginase/antagonists & inhibitors. J Med Chem 2011 Aug 11;54(15):5432-43
piceatannol-3'-O-glucopyranoside  0   *Glucosides *Stilbenes Arginase/antagonists & inhibitors Nitric Oxide Synthase Type III. Exp Mol Med 2010 Jul 31;42(7):524-32
2-amino-5-(2-aminoimidazol-1-yl)pentanoic acid  0   *Amino Acids *Imidazoles Arginase/antagonists & inhibitors. J Med Chem 2010 May 27;53(10):4266-76
Arg1 protein, mouse  EC 3.5.3.1   *Arginase. Am J Pathol. 2009 Aug;175(2):891-902
arginase I, rat  EC 3.5.3.1   *Arginase. J Neurosci. 2009 Jul 29;29(30):9545-52
ARG1 protein, S cerevisiae  EC 3.5.3.-   *Arginase *Saccharomyces cerevisiae Proteins. Biochem Biophys Res Commun 2009 Mar 27;381(1):123-8
Arg3 protein, Xenopus  EC 3.5.3.-   *Arginase *Xenopus Proteins.
Arg2 protein, Xenopus  EC 3.5.3.-   *Arginase *Xenopus Proteins.
CAR1 protein, S cerevisiae  EC 3.5.3.1   *Arginase *Saccharomyces cerevisiae Proteins.
car1 arginase protein, S pombe  EC 3.5.3.1   *Arginase *Schizosaccharomyces pombe Proteins.
Arg2 protein, mouse  EC 3.5.3.1   *Arginase. Am J Physiol Cell Physiol 2004 Feb;286(2);C206-12
arginase II, human  EC 3.5.3.1   *Arginase. Biochemistry 2003 Jul 22;42(28):8445-51
(2-boronoethyl)-cysteine  0   *Boronic Acids Arginase/antagonists & inhibitors. Biochemistry 2001 Mar 6;40(9):2678-88
N(omega)-hydroxynorarginine  0   Arginine/*analogs & derivatives Arginase/antagonists & inhibitors. Nitric Oxide 1999 Dec;3(6):427-38
RocF protein, Helicobacter pylori  EC 3.5.3.-   *Arginase *Bacterial Proteins. J Bacteriol 1999 Dec;181(23):7314-22
2-amino-6-boronohexanoic acid  0   *Aminocaproic Acids *Boron Compounds Arginase/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Sep;290(3):1409-16
Arg2 protein, rat  EC 3.5.3.1   *Arginase. Mol Genet Metab 1998 Mar;63(3):168-75
purified growth inhibitory factor, liver  EC 3.5.3.-   *Arginase Liver Growth Inhibitors. Biochim Biophys Acta 1997 Mar 1;1355(3):205-8
Arg1 protein, Xenopus  EC 3.5.3.-   *Arginase *Xenopus Proteins. J Biol Chem 1994 Oct 14;269(41):25328-34
2-amino-6-iodoacetamidohexanoic acid  90764-56-0   6-Aminocaproic Acid/*analogs & derivatives Arginase/antagonists & inhibitors Ornithine Decarboxylase/antagonists & inhibitors. Cancer Lett 1992 Dec 24;67(2-3):193-7
2-amino-5-iodoacetamidopentanoic acid  35748-65-3   *Amino Acids Arginase/antagonists & inhibitors Ornithine Decarboxylase/antagonists & inhibitors. Cancer Lett 1992 Dec 24;67(2-3):193-7
2-amino-5-iodoacetamidovaleric acid  63984-35-0   Ornithine/*analogs & derivatives Arginase/antagonists & inhibitors. Contraception 1986;33(6):597
monomethoxypolyethylene glycol-arginase  0   *Arginase *Polyethylene Glycols. Cancer Biochen Biophys 1984;7(3):261

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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